Outcomes and prognostic factors of simple partial cystectomy for localized bladder urothelial cell carcinoma
Radical cystectomy has remained the gold standard for recurrent superficial or muscle invasive bladder tumor. However, partial cystectomy still has a role in those who reject or have contraindications for radical cystectomy. In this study, we sought to identify predictors of bladder recurrence and o...
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doaj-8b918f5b3c8d48b69a61f070e47edb802020-11-24T22:09:36ZengWileyKaohsiung Journal of Medical Sciences1607-551X2016-04-0132419119510.1016/j.kjms.2016.02.008Outcomes and prognostic factors of simple partial cystectomy for localized bladder urothelial cell carcinomaI-Hung Shao0Ying-Hsu Chang1Kai-Jie Yu2Po-Hung Lin3Chung-Yi Liu4Cheng-Keng Chuang5See-Tong Pang6Division of Urology, Department of Surgery, Lotung Pohai Hospital, Yilan, TaiwanDivision of Urology, Department of Surgery, Chang Gung Memorial Hospital at Linkou, Chang Gung University College of Medicine, Taoyuan, TaiwanDivision of Urology, Department of Surgery, Chang Gung Memorial Hospital at Linkou, Chang Gung University College of Medicine, Taoyuan, TaiwanDivision of Urology, Department of Surgery, Chang Gung Memorial Hospital at Linkou, Chang Gung University College of Medicine, Taoyuan, TaiwanDivision of Urology, Department of Surgery, Chang Gung Memorial Hospital at Linkou, Chang Gung University College of Medicine, Taoyuan, TaiwanDivision of Urology, Department of Surgery, Chang Gung Memorial Hospital at Linkou, Chang Gung University College of Medicine, Taoyuan, TaiwanDivision of Urology, Department of Surgery, Chang Gung Memorial Hospital at Linkou, Chang Gung University College of Medicine, Taoyuan, TaiwanRadical cystectomy has remained the gold standard for recurrent superficial or muscle invasive bladder tumor. However, partial cystectomy still has a role in those who reject or have contraindications for radical cystectomy. In this study, we sought to identify predictors of bladder recurrence and overall survival after simple partial cystectomy. We included 27 patients with bladder tumor who received simple partial cystectomy without pelvic lymph node dissection between March 2000 and September 2013. Adjuvant chemotherapy or radiation therapy was prescribed according to the pathological results. Parameters were compared on the basis of bladder recurrence and overall survival. During a mean follow-up time of 39 months, five patients (18.5%) experienced bladder recurrence. An older age, a higher pathological stage, positive surgical margins, and distant metastases were significant predictors of overall survival (p = 0.031, p = 0.001, p = 0.001, and p = 0.011, respectively). Meanwhile, previous bladder instillation and positive surgical margins were significant predictors of bladder recurrence (p = 0.026 and p = 0.027, respectively). The rate of consecutive distant metastases (33.3%) was almost twice the rate of bladder recurrence (18.5%), and six patients developed consecutive distant metastases without first experiencing bladder recurrence. In patients who received a simple partial cystectomy as an alternative treatment, previous bladder instillation and positive surgical margins were significant predictors of bladder recurrence. Patients with an older age, positive surgical margins, and consecutive distant metastases had worse overall survival. Partial cystectomy with routine lymph node dissection may be a better option for achieving favorable long-term outcomes.http://www.sciencedirect.com/science/article/pii/S1607551X16000462Bladder tumorPartial cystectomyUrothelial carcinoma |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
I-Hung Shao Ying-Hsu Chang Kai-Jie Yu Po-Hung Lin Chung-Yi Liu Cheng-Keng Chuang See-Tong Pang |
spellingShingle |
I-Hung Shao Ying-Hsu Chang Kai-Jie Yu Po-Hung Lin Chung-Yi Liu Cheng-Keng Chuang See-Tong Pang Outcomes and prognostic factors of simple partial cystectomy for localized bladder urothelial cell carcinoma Kaohsiung Journal of Medical Sciences Bladder tumor Partial cystectomy Urothelial carcinoma |
author_facet |
I-Hung Shao Ying-Hsu Chang Kai-Jie Yu Po-Hung Lin Chung-Yi Liu Cheng-Keng Chuang See-Tong Pang |
author_sort |
I-Hung Shao |
title |
Outcomes and prognostic factors of simple partial cystectomy for localized bladder urothelial cell carcinoma |
title_short |
Outcomes and prognostic factors of simple partial cystectomy for localized bladder urothelial cell carcinoma |
title_full |
Outcomes and prognostic factors of simple partial cystectomy for localized bladder urothelial cell carcinoma |
title_fullStr |
Outcomes and prognostic factors of simple partial cystectomy for localized bladder urothelial cell carcinoma |
title_full_unstemmed |
Outcomes and prognostic factors of simple partial cystectomy for localized bladder urothelial cell carcinoma |
title_sort |
outcomes and prognostic factors of simple partial cystectomy for localized bladder urothelial cell carcinoma |
publisher |
Wiley |
series |
Kaohsiung Journal of Medical Sciences |
issn |
1607-551X |
publishDate |
2016-04-01 |
description |
Radical cystectomy has remained the gold standard for recurrent superficial or muscle invasive bladder tumor. However, partial cystectomy still has a role in those who reject or have contraindications for radical cystectomy. In this study, we sought to identify predictors of bladder recurrence and overall survival after simple partial cystectomy. We included 27 patients with bladder tumor who received simple partial cystectomy without pelvic lymph node dissection between March 2000 and September 2013. Adjuvant chemotherapy or radiation therapy was prescribed according to the pathological results. Parameters were compared on the basis of bladder recurrence and overall survival. During a mean follow-up time of 39 months, five patients (18.5%) experienced bladder recurrence. An older age, a higher pathological stage, positive surgical margins, and distant metastases were significant predictors of overall survival (p = 0.031, p = 0.001, p = 0.001, and p = 0.011, respectively). Meanwhile, previous bladder instillation and positive surgical margins were significant predictors of bladder recurrence (p = 0.026 and p = 0.027, respectively). The rate of consecutive distant metastases (33.3%) was almost twice the rate of bladder recurrence (18.5%), and six patients developed consecutive distant metastases without first experiencing bladder recurrence. In patients who received a simple partial cystectomy as an alternative treatment, previous bladder instillation and positive surgical margins were significant predictors of bladder recurrence. Patients with an older age, positive surgical margins, and consecutive distant metastases had worse overall survival. Partial cystectomy with routine lymph node dissection may be a better option for achieving favorable long-term outcomes. |
topic |
Bladder tumor Partial cystectomy Urothelial carcinoma |
url |
http://www.sciencedirect.com/science/article/pii/S1607551X16000462 |
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