Co-infection by Semliki forest virus and malarial parasite modulates viral multiplication, pathogenesis and cytokines in mice
Environmental, technological and societal factors continue to have a dramatic effect on infectious diseases worldwide and are considered to be facilitating the emergence of several infectious diseases at a time. Co-infection with different species of viral and malaria infections are currently emergi...
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Online Access: | http://dx.doi.org/10.1051/parasite/2006133251 |
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doaj-8b920b657cbe476688ccbfeb46f65e8a2021-02-02T03:50:18ZengEDP SciencesParasite1252-607X1776-10422006-09-0113325125510.1051/parasite/2006133251parasite2006133p251Co-infection by Semliki forest virus and malarial parasite modulates viral multiplication, pathogenesis and cytokines in miceGupta P.Seth P.Husain M.M.Puri S.K.Maheshwari R.K.Environmental, technological and societal factors continue to have a dramatic effect on infectious diseases worldwide and are considered to be facilitating the emergence of several infectious diseases at a time. Co-infection with different species of viral and malaria infections are currently emerging problems of dual infection in the developing as well as developed countries. Understanding of interactions between the host, malaria and virus infection is of current concern and we have initiated studies to delineate the mechanisms involved during the progression of Semliki forest virus (SFV) and Plasmodium yoelii (P. yoelii) infection in mice. Enhanced virus multiplication and up-regulation of cytokine mRNA level in P. yoelii and SFV co-infected mice were observed on day 4 post-infection compared to respective controls. Collectively, our observations indicate that malaria infection may influence virus multiplication, pathogenesis and up-regulation of cytokine mRNA during co-infection in mice.http://dx.doi.org/10.1051/parasite/2006133251co-infectionvirusmalarial parasiteP. yoeliipathologycytokine |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Gupta P. Seth P. Husain M.M. Puri S.K. Maheshwari R.K. |
spellingShingle |
Gupta P. Seth P. Husain M.M. Puri S.K. Maheshwari R.K. Co-infection by Semliki forest virus and malarial parasite modulates viral multiplication, pathogenesis and cytokines in mice Parasite co-infection virus malarial parasite P. yoelii pathology cytokine |
author_facet |
Gupta P. Seth P. Husain M.M. Puri S.K. Maheshwari R.K. |
author_sort |
Gupta P. |
title |
Co-infection by Semliki forest virus and malarial parasite modulates viral multiplication, pathogenesis and cytokines in mice |
title_short |
Co-infection by Semliki forest virus and malarial parasite modulates viral multiplication, pathogenesis and cytokines in mice |
title_full |
Co-infection by Semliki forest virus and malarial parasite modulates viral multiplication, pathogenesis and cytokines in mice |
title_fullStr |
Co-infection by Semliki forest virus and malarial parasite modulates viral multiplication, pathogenesis and cytokines in mice |
title_full_unstemmed |
Co-infection by Semliki forest virus and malarial parasite modulates viral multiplication, pathogenesis and cytokines in mice |
title_sort |
co-infection by semliki forest virus and malarial parasite modulates viral multiplication, pathogenesis and cytokines in mice |
publisher |
EDP Sciences |
series |
Parasite |
issn |
1252-607X 1776-1042 |
publishDate |
2006-09-01 |
description |
Environmental, technological and societal factors continue to have a dramatic effect on infectious diseases worldwide and are considered to be facilitating the emergence of several infectious diseases at a time. Co-infection with different species of viral and malaria infections are currently emerging problems of dual infection in the developing as well as developed countries. Understanding of interactions between the host, malaria and virus infection is of current concern and we have initiated studies to delineate the mechanisms involved during the progression of Semliki forest virus (SFV) and Plasmodium yoelii (P. yoelii) infection in mice. Enhanced virus multiplication and up-regulation of cytokine mRNA level in P. yoelii and SFV co-infected mice were observed on day 4 post-infection compared to respective controls. Collectively, our observations indicate that malaria infection may influence virus multiplication, pathogenesis and up-regulation of cytokine mRNA during co-infection in mice. |
topic |
co-infection virus malarial parasite P. yoelii pathology cytokine |
url |
http://dx.doi.org/10.1051/parasite/2006133251 |
work_keys_str_mv |
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