27-Hydroxycholesterol: production rates in normal human subjects

27-Hydroxycholesterol: production rates in normal human subjects

We attempted to quantitate production of bile acid via the 27-hydroxylation pathway in six human subjects. After bolus intravenous injection of known amounts of [24-14C]cholic acid and [24-14C]chenodeoxycholic acid, each subject underwent a constant intravenous infusion of a mixture of [22,23-3H]-27...

Full description

Bibliographic Details
Main Authors:	William C. Duane, Norman B. Javitt
Format:	Article
Language:	English
Published:	Elsevier 1999-07-01
Series:	Journal of Lipid Research
Subjects:	bile acids and salts oxysterols cholesterol atherosclerosis cholelithiasis
Online Access:	http://www.sciencedirect.com/science/article/pii/S0022227520334817

Similar Items

Diminished gene expression of ileal apical sodium bile acid transporter explains impaired absorption of bile acid in patients with hypertriglyceridemia
by: William C. Duane, et al.
Published: (2000-09-01)

24-Hydroxycholesterol is a substrate for hepatic cholesterol 7α-hydroxylase (CYP7A)
by: Maria Norlin, et al.
Published: (2000-10-01)

CYP7A1 promoter polymorphism −203A>C affects bile salt synthesis rate in patients after ileal resection
by: Martin Leníček, et al.
Published: (2008-12-01)

Involvement of 27-Hydroxycholesterol in Mitotane Action on Adrenocortical Carcinoma
by: Antonina Germano, et al.
Published: (2020-04-01)

A novel intrinsically fluorescent probe for study of uptake and trafficking of 25-hydroxycholesterol
by: David B. Iaea, et al.
Published: (2015-12-01)

Marked accumulation of 27-hydroxycholesterol in the brains of Alzheimer's patients with the Swedish APP 670/671 mutation
by: Marjan Shafaati, et al.
Published: (2011-05-01)

Dietary Factors Influencing the Pathogenesis of Gallstone Disease in Kerala, India
by: TG Raghu
Published: (2021-04-01)

Current knowledge on the mechanism of atherosclerosis and pro-atherosclerotic properties of oxysterols
by: Adam Zmysłowski, et al.
Published: (2017-10-01)

Crossing the barrier: net flux of 27-hydroxycholesterol into the human brain
by: Maura Heverin, et al.
Published: (2005-05-01)

Influence of Chitosan Treatment on Surrogate Serum Markers of Cholesterol Metabolism in Obese Subjects
by: Dieter Lütjohann, et al.
Published: (2018-01-01)

The Controversial Role of 24-S-Hydroxycholesterol in Alzheimer’s Disease
by: Paola Gamba, et al.
Published: (2021-05-01)

Regulation of fibroblast mitochondrial 27-hydroxycholesterol production by active plasma membrane cholesterol
by: Yvonne Lange, et al.
Published: (2009-09-01)

Stimulated Bile Production and Outflow in the Prevention and Treatment of Acute Hepatic Failure
by: R. V. Bukhov
Published: (2006-02-01)

The cholesterol metabolite 27-hydroxycholesterol inhibits SARS-CoV-2 and is markedly decreased in COVID-19 patients
by: Alessandro Marcello, et al.
Published: (2020-09-01)

Identification of a novel sulfonated oxysterol, 5-cholesten-3β,25-diol 3-sulfonate, in hepatocyte nuclei and mitochondria
by: Shunlin Ren, et al.
Published: (2006-05-01)

Bile acid and cholesterol metabolism in atherosclerotic cardiovascular disease and therapy
by: John Y. L. Chiang, et al.
Published: (2020-01-01)

Determination of 24S- and 27-hydroxycholesterol in plasma by high-performance liquid chromatography-mass spectrometry
by: Ines Burkard, et al.
Published: (2004-04-01)

25R,26-Hydroxycholesterol revisited: synthesis, metabolism, and biologic roles
by: Norman B. Javitt
Published: (2002-05-01)

Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis
by: Rebecca Schüle, et al.
Published: (2010-04-01)

Aerobic Exercise Training Selectively Changes Oxysterol Levels and Metabolism Reducing Cholesterol Accumulation in the Aorta of Dyslipidemic Mice
by: Guilherme Silva Ferreira, et al.
Published: (2017-09-01)

The Cerebrospinal Fluid Profile of Cholesterol Metabolites in Parkinson’s Disease and Their Association With Disease State and Clinical Features
by: William J. Griffiths, et al.
Published: (2021-08-01)

Food Protein Sterylation: Chemical Reactions between Reactive Amino Acids and Sterol Oxidation Products under Food Processing Conditions
by: Franks Kamgang Nzekoue, et al.
Published: (2020-12-01)

EPA-enriched ethanolamine plasmalogen alleviates atherosclerosis via mediating bile acids metabolism
by: Lin Ding, et al.
Published: (2020-03-01)

Quantitation of cholesterol-carrying particles in human gallbladder bile
by: Erik R.M. Eckhardt, et al.
Published: (1998-03-01)

Cholesterol Metabolites 25-Hydroxycholesterol and 25-Hydroxycholesterol 3-Sulfate Are Potent Paired Regulators: From Discovery to Clinical Usage
by: Yaping Wang, et al.
Published: (2021-12-01)

The Liver under the Spotlight: Bile Acids and Oxysterols as Pivotal Actors Controlling Metabolism
by: Charlotte Lefort, et al.
Published: (2021-02-01)

Comparative analysis of bile acid spectrum in non-alcoholic fatty liver disease and cholelithiasis
by: Ya M Vakhrushev, et al.
Published: (2019-02-01)

Metabolic profiling in serum, cerebrospinal fluid, and brain of patients with cerebrotendinous xanthomatosis
by: Philip Höflinger, et al.
Published: (2021-01-01)

Impaired response of biliary lipid secretion to a lithogenic diet in phosphatidylcholine transfer protein-deficient mice
by: Michele K. Wu, et al.
Published: (2005-03-01)

Alterations in biliary lipids of mice during dehydrocholic acid feeding
by: Nicholas W. DiTullio, et al.
Published: (1973-09-01)

Defective cholesterol metabolism in amyotrophic lateral sclerosis
by: Jonas Abdel-Khalik, et al.
Published: (2017-01-01)

Comprehensive review of strategies for diagnosis and treatment of hepatolithiasis
by: KONG Jing, et al.
Published: (2013-03-01)

Expression of cholesterol-7α-hydroxylase in murine macrophages prevents cholesterol loading by acetyl-LDL
by: Gina L. Moore, et al.
Published: (2002-04-01)

The human gallbladder microbiome is related to the physiological state and the biliary metabolic profile
by: Natalia Molinero, et al.
Published: (2019-07-01)

BAREing it all: the adoption of LXR and FXR and their roles in lipid homeostasis
by: Peter A. Edwards, et al.
Published: (2002-01-01)

Functional and Phylogenetic Diversity of BSH and PVA Enzymes
by: Jack W. Daly, et al.
Published: (2021-03-01)

Micro flora of Bile Aspirates in Symptomatic Cholelithiasis
by: Zafar Iqbal Malik
Published: (2009-06-01)

Cholesterol 7α-hydroxylase-deficient mice are protected from high-fat/high-cholesterol diet-induced metabolic disorders[S]
by: Jessica M. Ferrell, et al.
Published: (2016-07-01)

The composition of bile acids in patients with cholelithiasis according to the data of liquid chromatography with mass spectrometric detection
by: V. M. Klymenko, et al.
Published: (2017-12-01)

Oxysterol binding protein-related protein 8 mediates the cytotoxicity of 25-hydroxycholesterol[S]
by: Jiwei Li, et al.
Published: (2016-10-01)