Biological Functions and Analytical Strategies of Sialic Acids in Tumor

Sialic acids, a subset of nine carbon acidic sugars, often exist as the terminal sugars of glycans on either glycoproteins or glycolipids on the cell surface. Sialic acids play important roles in many physiological and pathological processes via carbohydrate-protein interactions, including cell&...

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Main Authors: Xiaoman Zhou, Ganglong Yang, Feng Guan
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Cells
Subjects:
Online Access:https://www.mdpi.com/2073-4409/9/2/273
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spelling doaj-8b9f2c2a5bb549d8bb7b04f24a8dd9502020-11-25T01:30:14ZengMDPI AGCells2073-44092020-01-019227310.3390/cells9020273cells9020273Biological Functions and Analytical Strategies of Sialic Acids in TumorXiaoman Zhou0Ganglong Yang1Feng Guan2The Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, ChinaThe Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, ChinaThe Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, ChinaSialic acids, a subset of nine carbon acidic sugars, often exist as the terminal sugars of glycans on either glycoproteins or glycolipids on the cell surface. Sialic acids play important roles in many physiological and pathological processes via carbohydrate-protein interactions, including cell−cell communication, bacterial and viral infections. In particular, hypersialylation in tumors, as well as their roles in tumor growth and metastasis, have been widely described. Recent studies have indicated that the aberrant sialylation is a vital way for tumor cells to escape immune surveillance and keep malignance. In this article, we outline the present state of knowledge on the metabolic pathway of human sialic acids, the function of hypersialylation in tumors, as well as the recent labeling and analytical techniques for sialic acids. It is expected to offer a brief introduction of sialic acid metabolism and provide advanced analytical strategies in sialic acid studies.https://www.mdpi.com/2073-4409/9/2/273sialic acidsialyltransferasesialidasetumor sialylationsialic acid labeling
collection DOAJ
language English
format Article
sources DOAJ
author Xiaoman Zhou
Ganglong Yang
Feng Guan
spellingShingle Xiaoman Zhou
Ganglong Yang
Feng Guan
Biological Functions and Analytical Strategies of Sialic Acids in Tumor
Cells
sialic acid
sialyltransferase
sialidase
tumor sialylation
sialic acid labeling
author_facet Xiaoman Zhou
Ganglong Yang
Feng Guan
author_sort Xiaoman Zhou
title Biological Functions and Analytical Strategies of Sialic Acids in Tumor
title_short Biological Functions and Analytical Strategies of Sialic Acids in Tumor
title_full Biological Functions and Analytical Strategies of Sialic Acids in Tumor
title_fullStr Biological Functions and Analytical Strategies of Sialic Acids in Tumor
title_full_unstemmed Biological Functions and Analytical Strategies of Sialic Acids in Tumor
title_sort biological functions and analytical strategies of sialic acids in tumor
publisher MDPI AG
series Cells
issn 2073-4409
publishDate 2020-01-01
description Sialic acids, a subset of nine carbon acidic sugars, often exist as the terminal sugars of glycans on either glycoproteins or glycolipids on the cell surface. Sialic acids play important roles in many physiological and pathological processes via carbohydrate-protein interactions, including cell−cell communication, bacterial and viral infections. In particular, hypersialylation in tumors, as well as their roles in tumor growth and metastasis, have been widely described. Recent studies have indicated that the aberrant sialylation is a vital way for tumor cells to escape immune surveillance and keep malignance. In this article, we outline the present state of knowledge on the metabolic pathway of human sialic acids, the function of hypersialylation in tumors, as well as the recent labeling and analytical techniques for sialic acids. It is expected to offer a brief introduction of sialic acid metabolism and provide advanced analytical strategies in sialic acid studies.
topic sialic acid
sialyltransferase
sialidase
tumor sialylation
sialic acid labeling
url https://www.mdpi.com/2073-4409/9/2/273
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AT ganglongyang biologicalfunctionsandanalyticalstrategiesofsialicacidsintumor
AT fengguan biologicalfunctionsandanalyticalstrategiesofsialicacidsintumor
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