Biological Functions and Analytical Strategies of Sialic Acids in Tumor
Sialic acids, a subset of nine carbon acidic sugars, often exist as the terminal sugars of glycans on either glycoproteins or glycolipids on the cell surface. Sialic acids play important roles in many physiological and pathological processes via carbohydrate-protein interactions, including cell&...
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doaj-8b9f2c2a5bb549d8bb7b04f24a8dd9502020-11-25T01:30:14ZengMDPI AGCells2073-44092020-01-019227310.3390/cells9020273cells9020273Biological Functions and Analytical Strategies of Sialic Acids in TumorXiaoman Zhou0Ganglong Yang1Feng Guan2The Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, ChinaThe Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, ChinaThe Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, ChinaSialic acids, a subset of nine carbon acidic sugars, often exist as the terminal sugars of glycans on either glycoproteins or glycolipids on the cell surface. Sialic acids play important roles in many physiological and pathological processes via carbohydrate-protein interactions, including cell−cell communication, bacterial and viral infections. In particular, hypersialylation in tumors, as well as their roles in tumor growth and metastasis, have been widely described. Recent studies have indicated that the aberrant sialylation is a vital way for tumor cells to escape immune surveillance and keep malignance. In this article, we outline the present state of knowledge on the metabolic pathway of human sialic acids, the function of hypersialylation in tumors, as well as the recent labeling and analytical techniques for sialic acids. It is expected to offer a brief introduction of sialic acid metabolism and provide advanced analytical strategies in sialic acid studies.https://www.mdpi.com/2073-4409/9/2/273sialic acidsialyltransferasesialidasetumor sialylationsialic acid labeling |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xiaoman Zhou Ganglong Yang Feng Guan |
spellingShingle |
Xiaoman Zhou Ganglong Yang Feng Guan Biological Functions and Analytical Strategies of Sialic Acids in Tumor Cells sialic acid sialyltransferase sialidase tumor sialylation sialic acid labeling |
author_facet |
Xiaoman Zhou Ganglong Yang Feng Guan |
author_sort |
Xiaoman Zhou |
title |
Biological Functions and Analytical Strategies of Sialic Acids in Tumor |
title_short |
Biological Functions and Analytical Strategies of Sialic Acids in Tumor |
title_full |
Biological Functions and Analytical Strategies of Sialic Acids in Tumor |
title_fullStr |
Biological Functions and Analytical Strategies of Sialic Acids in Tumor |
title_full_unstemmed |
Biological Functions and Analytical Strategies of Sialic Acids in Tumor |
title_sort |
biological functions and analytical strategies of sialic acids in tumor |
publisher |
MDPI AG |
series |
Cells |
issn |
2073-4409 |
publishDate |
2020-01-01 |
description |
Sialic acids, a subset of nine carbon acidic sugars, often exist as the terminal sugars of glycans on either glycoproteins or glycolipids on the cell surface. Sialic acids play important roles in many physiological and pathological processes via carbohydrate-protein interactions, including cell−cell communication, bacterial and viral infections. In particular, hypersialylation in tumors, as well as their roles in tumor growth and metastasis, have been widely described. Recent studies have indicated that the aberrant sialylation is a vital way for tumor cells to escape immune surveillance and keep malignance. In this article, we outline the present state of knowledge on the metabolic pathway of human sialic acids, the function of hypersialylation in tumors, as well as the recent labeling and analytical techniques for sialic acids. It is expected to offer a brief introduction of sialic acid metabolism and provide advanced analytical strategies in sialic acid studies. |
topic |
sialic acid sialyltransferase sialidase tumor sialylation sialic acid labeling |
url |
https://www.mdpi.com/2073-4409/9/2/273 |
work_keys_str_mv |
AT xiaomanzhou biologicalfunctionsandanalyticalstrategiesofsialicacidsintumor AT ganglongyang biologicalfunctionsandanalyticalstrategiesofsialicacidsintumor AT fengguan biologicalfunctionsandanalyticalstrategiesofsialicacidsintumor |
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