Epigenetically reprogrammed methylation landscape drives the DNA self-assembly and serves as a universal cancer biomarker

DNA methylation is an epigenetic modification that control genetic programs. Here, the authors found that the methylation landscape influences the physicochemical properties of DNA and that it can serve as a universal cancer biomarker, and developed a one-step assay for the detection of cancer DNA.

Bibliographic Details
Main Authors:	Abu Ali Ibn Sina, Laura G. Carrascosa, Ziyu Liang, Yadveer S. Grewal, Andri Wardiana, Muhammad J. A. Shiddiky, Robert A. Gardiner, Hemamali Samaratunga, Maher K. Gandhi, Rodney J. Scott, Darren Korbie, Matt Trau
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-12-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-07214-w

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spelling	doaj-8ba444c0c7b149acac89adbdeaa840642021-05-11T09:29:24ZengNature Publishing GroupNature Communications2041-17232018-12-019111310.1038/s41467-018-07214-wEpigenetically reprogrammed methylation landscape drives the DNA self-assembly and serves as a universal cancer biomarkerAbu Ali Ibn Sina0Laura G. Carrascosa1Ziyu Liang2Yadveer S. Grewal3Andri Wardiana4Muhammad J. A. Shiddiky5Robert A. Gardiner6Hemamali Samaratunga7Maher K. Gandhi8Rodney J. Scott9Darren Korbie10Matt Trau11Center for Personalised Nanomedicine, Australian Institute for Bioengineering and Nanotechnology (AIBN), Corner of College and Cooper Roads (Bldg 75), The University of QueenslandCenter for Personalised Nanomedicine, Australian Institute for Bioengineering and Nanotechnology (AIBN), Corner of College and Cooper Roads (Bldg 75), The University of QueenslandCenter for Personalised Nanomedicine, Australian Institute for Bioengineering and Nanotechnology (AIBN), Corner of College and Cooper Roads (Bldg 75), The University of QueenslandCenter for Personalised Nanomedicine, Australian Institute for Bioengineering and Nanotechnology (AIBN), Corner of College and Cooper Roads (Bldg 75), The University of QueenslandCenter for Personalised Nanomedicine, Australian Institute for Bioengineering and Nanotechnology (AIBN), Corner of College and Cooper Roads (Bldg 75), The University of QueenslandCenter for Personalised Nanomedicine, Australian Institute for Bioengineering and Nanotechnology (AIBN), Corner of College and Cooper Roads (Bldg 75), The University of QueenslandSchool of Medicine, The University of QueenslandSchool of Medicine, The University of QueenslandDiamantina Institute, The University of QueenslandSchool of Biomedical Science and Pharmacy, The University of NewcastleCenter for Personalised Nanomedicine, Australian Institute for Bioengineering and Nanotechnology (AIBN), Corner of College and Cooper Roads (Bldg 75), The University of QueenslandCenter for Personalised Nanomedicine, Australian Institute for Bioengineering and Nanotechnology (AIBN), Corner of College and Cooper Roads (Bldg 75), The University of QueenslandDNA methylation is an epigenetic modification that control genetic programs. Here, the authors found that the methylation landscape influences the physicochemical properties of DNA and that it can serve as a universal cancer biomarker, and developed a one-step assay for the detection of cancer DNA.https://doi.org/10.1038/s41467-018-07214-w
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Abu Ali Ibn Sina Laura G. Carrascosa Ziyu Liang Yadveer S. Grewal Andri Wardiana Muhammad J. A. Shiddiky Robert A. Gardiner Hemamali Samaratunga Maher K. Gandhi Rodney J. Scott Darren Korbie Matt Trau
spellingShingle	Abu Ali Ibn Sina Laura G. Carrascosa Ziyu Liang Yadveer S. Grewal Andri Wardiana Muhammad J. A. Shiddiky Robert A. Gardiner Hemamali Samaratunga Maher K. Gandhi Rodney J. Scott Darren Korbie Matt Trau Epigenetically reprogrammed methylation landscape drives the DNA self-assembly and serves as a universal cancer biomarker Nature Communications
author_facet	Abu Ali Ibn Sina Laura G. Carrascosa Ziyu Liang Yadveer S. Grewal Andri Wardiana Muhammad J. A. Shiddiky Robert A. Gardiner Hemamali Samaratunga Maher K. Gandhi Rodney J. Scott Darren Korbie Matt Trau
author_sort	Abu Ali Ibn Sina
title	Epigenetically reprogrammed methylation landscape drives the DNA self-assembly and serves as a universal cancer biomarker
title_short	Epigenetically reprogrammed methylation landscape drives the DNA self-assembly and serves as a universal cancer biomarker
title_full	Epigenetically reprogrammed methylation landscape drives the DNA self-assembly and serves as a universal cancer biomarker
title_fullStr	Epigenetically reprogrammed methylation landscape drives the DNA self-assembly and serves as a universal cancer biomarker
title_full_unstemmed	Epigenetically reprogrammed methylation landscape drives the DNA self-assembly and serves as a universal cancer biomarker
title_sort	epigenetically reprogrammed methylation landscape drives the dna self-assembly and serves as a universal cancer biomarker
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-12-01
description	DNA methylation is an epigenetic modification that control genetic programs. Here, the authors found that the methylation landscape influences the physicochemical properties of DNA and that it can serve as a universal cancer biomarker, and developed a one-step assay for the detection of cancer DNA.
url	https://doi.org/10.1038/s41467-018-07214-w
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Epigenetically reprogrammed methylation landscape drives the DNA self-assembly and serves as a universal cancer biomarker

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