Multiscale Experimental Evaluation of Agarose-Based Semi-Interpenetrating Polymer Network Hydrogels as Materials with Tunable Rheological and Transport Performance
This study introduces an original concept in the development of hydrogel materials for controlled release of charged organic compounds based on semi-interpenetrating polymer networks composed by an inert gel-forming polymer component and interpenetrating linear polyelectrolyte with specific binding...
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doaj-8bb742755c904ed1839184d270c7f3a32020-11-25T04:02:09ZengMDPI AGPolymers2073-43602020-10-01122561256110.3390/polym12112561Multiscale Experimental Evaluation of Agarose-Based Semi-Interpenetrating Polymer Network Hydrogels as Materials with Tunable Rheological and Transport PerformanceMonika Trudicova0Jiri Smilek1Michal Kalina2Marcela Smilkova3Katerina Adamkova4Kamila Hrubanova5Vladislav Krzyzanek6Petr Sedlacek7Faculty of Chemistry, Brno University of Technology, Purkynova 118, 61200 Brno, Czech RepublicFaculty of Chemistry, Brno University of Technology, Purkynova 118, 61200 Brno, Czech RepublicFaculty of Chemistry, Brno University of Technology, Purkynova 118, 61200 Brno, Czech RepublicFaculty of Chemistry, Brno University of Technology, Purkynova 118, 61200 Brno, Czech RepublicInstitute of Scientific Instruments of the Czech Academy of Sciences, Kralovopolska 147, 61264 Brno, Czech RepublicInstitute of Scientific Instruments of the Czech Academy of Sciences, Kralovopolska 147, 61264 Brno, Czech RepublicInstitute of Scientific Instruments of the Czech Academy of Sciences, Kralovopolska 147, 61264 Brno, Czech RepublicFaculty of Chemistry, Brno University of Technology, Purkynova 118, 61200 Brno, Czech RepublicThis study introduces an original concept in the development of hydrogel materials for controlled release of charged organic compounds based on semi-interpenetrating polymer networks composed by an inert gel-forming polymer component and interpenetrating linear polyelectrolyte with specific binding affinity towards the carried active compound. As it is experimentally illustrated on the prototype hydrogels prepared from agarose interpenetrated by poly(styrene sulfonate) (PSS) and alginate (ALG), respectively, the main benefit brought by this concept is represented by the ability to tune the mechanical and transport performance of the material independently via manipulating the relative content of the two structural components. A unique analytical methodology is proposed to provide complex insight into composition–structure–performance relationships in the hydrogel material combining methods of analysis on the macroscopic scale, but also in the specific microcosms of the gel network. Rheological analysis has confirmed that the complex modulus of the gels can be adjusted in a wide range by the gelling component (agarose) with negligible effect of the interpenetrating component (PSS or ALG). On the other hand, the content of PSS as low as 0.01 wt.% of the gel resulted in a more than 10-fold decrease of diffusivity of model-charged organic solute (Rhodamine 6G).https://www.mdpi.com/2073-4360/12/11/2561hydrogelssemi-interpenetrating polymer networkscontrolled release systemsrheologydiffusioncryo-scanning electron microscopy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Monika Trudicova Jiri Smilek Michal Kalina Marcela Smilkova Katerina Adamkova Kamila Hrubanova Vladislav Krzyzanek Petr Sedlacek |
spellingShingle |
Monika Trudicova Jiri Smilek Michal Kalina Marcela Smilkova Katerina Adamkova Kamila Hrubanova Vladislav Krzyzanek Petr Sedlacek Multiscale Experimental Evaluation of Agarose-Based Semi-Interpenetrating Polymer Network Hydrogels as Materials with Tunable Rheological and Transport Performance Polymers hydrogels semi-interpenetrating polymer networks controlled release systems rheology diffusion cryo-scanning electron microscopy |
author_facet |
Monika Trudicova Jiri Smilek Michal Kalina Marcela Smilkova Katerina Adamkova Kamila Hrubanova Vladislav Krzyzanek Petr Sedlacek |
author_sort |
Monika Trudicova |
title |
Multiscale Experimental Evaluation of Agarose-Based Semi-Interpenetrating Polymer Network Hydrogels as Materials with Tunable Rheological and Transport Performance |
title_short |
Multiscale Experimental Evaluation of Agarose-Based Semi-Interpenetrating Polymer Network Hydrogels as Materials with Tunable Rheological and Transport Performance |
title_full |
Multiscale Experimental Evaluation of Agarose-Based Semi-Interpenetrating Polymer Network Hydrogels as Materials with Tunable Rheological and Transport Performance |
title_fullStr |
Multiscale Experimental Evaluation of Agarose-Based Semi-Interpenetrating Polymer Network Hydrogels as Materials with Tunable Rheological and Transport Performance |
title_full_unstemmed |
Multiscale Experimental Evaluation of Agarose-Based Semi-Interpenetrating Polymer Network Hydrogels as Materials with Tunable Rheological and Transport Performance |
title_sort |
multiscale experimental evaluation of agarose-based semi-interpenetrating polymer network hydrogels as materials with tunable rheological and transport performance |
publisher |
MDPI AG |
series |
Polymers |
issn |
2073-4360 |
publishDate |
2020-10-01 |
description |
This study introduces an original concept in the development of hydrogel materials for controlled release of charged organic compounds based on semi-interpenetrating polymer networks composed by an inert gel-forming polymer component and interpenetrating linear polyelectrolyte with specific binding affinity towards the carried active compound. As it is experimentally illustrated on the prototype hydrogels prepared from agarose interpenetrated by poly(styrene sulfonate) (PSS) and alginate (ALG), respectively, the main benefit brought by this concept is represented by the ability to tune the mechanical and transport performance of the material independently via manipulating the relative content of the two structural components. A unique analytical methodology is proposed to provide complex insight into composition–structure–performance relationships in the hydrogel material combining methods of analysis on the macroscopic scale, but also in the specific microcosms of the gel network. Rheological analysis has confirmed that the complex modulus of the gels can be adjusted in a wide range by the gelling component (agarose) with negligible effect of the interpenetrating component (PSS or ALG). On the other hand, the content of PSS as low as 0.01 wt.% of the gel resulted in a more than 10-fold decrease of diffusivity of model-charged organic solute (Rhodamine 6G). |
topic |
hydrogels semi-interpenetrating polymer networks controlled release systems rheology diffusion cryo-scanning electron microscopy |
url |
https://www.mdpi.com/2073-4360/12/11/2561 |
work_keys_str_mv |
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