Distal chromosome 1q aberrations and initial response to ibrutinib in central nervous system relapsed mantle cell lymphoma

• Main Authors: Marcus Høy Hansen, Karen Juul-Jensen, Oriane Cédile, Stephanie Kavan, Michael Boe Møller, Jacob Haaber, Charlotte Guldborg Nyvold
• Format: Article
• Language: English
• Published: Elsevier 2021-01-01
• Series: Leukemia Research Reports
• Subjects: Mantle cell lymphoma; Central nervous system relapse; Copy number alteration; Chromosome 1 aberration; Ibrutinib response
• Online Access: http://www.sciencedirect.com/science/article/pii/S2213048921000224

Relapse involving the central nervous system (CNS) is an infrequent event in the progression of mantle cell lymphoma (MCL) with an incidence of approximately four percent. We report four cases of MCL with CNS relapse. In three of the four patients a large chromosomal copy-number alteration (CNA) of 1q was demonstrated together with TP53 mutation/deletion. These patients experienced brief response to ibrutinib, whereas a fourth patient harboring mutated ATM demonstrated a long-term effect to ibrutinib and no CNA. Although it is unclear whether chromosome 1q CNA contribute to specific phenotypes these reports may be of value as such lesions are uncommon features of MCL.