Microenvironment-Induced Non-sporadic Expression of the AXL and cKIT Receptors Are Related to Epithelial Plasticity and Drug Resistance

Microenvironment-Induced Non-sporadic Expression of the AXL and cKIT Receptors Are Related to Epithelial Plasticity and Drug Resistance

The existence of rare cancer cells that sporadically acquire drug-tolerance through epigenetic mechanisms is proposed as one mechanism that drives cancer therapy failure. Here we provide evidence that specific microenvironments impose non-sporadic expression of proteins related to epithelial plastic...

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Bibliographic Details
Main Authors: Tiina A. Jokela, Agnete S. T. Engelsen, Agata Rybicka, Fanny A. Pelissier Vatter, James C. Garbe, Masaru Miyano, Crina Tiron, Dan Ferariu, Lars A. Akslen, Martha R. Stampfer, James B. Lorens, Mark A. LaBarge
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
breast cancer
MEMA
microenvironment
epithelial plasticity
AXL
cKIT
Online Access:http://journal.frontiersin.org/article/10.3389/fcell.2018.00041/full

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