Ultra-long-acting tunable biodegradable and removable controlled release implants for drug delivery
Patient drug regime compliance is a major issue; sustained release implants could address this. Here, the authors report on a phase inverted in situ forming implant of PLGA for the sustained release of antiretroviral drugs and optimize and demonstrate the release of 6 different drugs over a period o...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2019-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-12141-5 |
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doaj-8bc4a989ec17413397ece8fc45f936862021-05-11T12:30:35ZengNature Publishing GroupNature Communications2041-17232019-09-0110111210.1038/s41467-019-12141-5Ultra-long-acting tunable biodegradable and removable controlled release implants for drug deliveryS. Rahima Benhabbour0Martina Kovarova1Clinton Jones2Daijha J. Copeland3Roopali Shrivastava4Michael D. Swanson5Craig Sykes6Phong T. Ho7Mackenzie L. Cottrell8Anush Sridharan9Samantha M. Fix10Orrin Thayer11Julie M. Long12Daria J. Hazuda13Paul A. Dayton14Russell J. Mumper15Angela D. M. Kashuba16J. Victor Garcia17UNC_NCSU Joint Department of Biomedical Engineering, University of North Carolina at Chapel HillInternational Center for the Advancement of Translational Science, Division of Infectious Diseases, Center for Aids Research, School of Medicine, University of North Carolina at Chapel HillUNC Eshelman School of Pharmacy, Division of Pharmacoengineering and Molecular PharmaceuticsUNC Eshelman School of Pharmacy, Division of Pharmacoengineering and Molecular PharmaceuticsUNC_NCSU Joint Department of Biomedical Engineering, University of North Carolina at Chapel HillInternational Center for the Advancement of Translational Science, Division of Infectious Diseases, Center for Aids Research, School of Medicine, University of North Carolina at Chapel HillDivision of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel HillInternational Center for the Advancement of Translational Science, Division of Infectious Diseases, Center for Aids Research, School of Medicine, University of North Carolina at Chapel HillInternational Center for the Advancement of Translational Science, Division of Infectious Diseases, Center for Aids Research, School of Medicine, University of North Carolina at Chapel HillUNC_NCSU Joint Department of Biomedical Engineering, University of North Carolina at Chapel HillUNC Eshelman School of Pharmacy, Division of Pharmacoengineering and Molecular PharmaceuticsInternational Center for the Advancement of Translational Science, Division of Infectious Diseases, Center for Aids Research, School of Medicine, University of North Carolina at Chapel HillInternational Center for the Advancement of Translational Science, Division of Infectious Diseases, Center for Aids Research, School of Medicine, University of North Carolina at Chapel HillInfectious Disease Biology, Merck Research LaboratoriesUNC_NCSU Joint Department of Biomedical Engineering, University of North Carolina at Chapel HillUniversity of Georgia, Office of the ProvostDivision of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel HillInternational Center for the Advancement of Translational Science, Division of Infectious Diseases, Center for Aids Research, School of Medicine, University of North Carolina at Chapel HillPatient drug regime compliance is a major issue; sustained release implants could address this. Here, the authors report on a phase inverted in situ forming implant of PLGA for the sustained release of antiretroviral drugs and optimize and demonstrate the release of 6 different drugs over a period of up to a year.https://doi.org/10.1038/s41467-019-12141-5 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
S. Rahima Benhabbour Martina Kovarova Clinton Jones Daijha J. Copeland Roopali Shrivastava Michael D. Swanson Craig Sykes Phong T. Ho Mackenzie L. Cottrell Anush Sridharan Samantha M. Fix Orrin Thayer Julie M. Long Daria J. Hazuda Paul A. Dayton Russell J. Mumper Angela D. M. Kashuba J. Victor Garcia |
| spellingShingle |
S. Rahima Benhabbour Martina Kovarova Clinton Jones Daijha J. Copeland Roopali Shrivastava Michael D. Swanson Craig Sykes Phong T. Ho Mackenzie L. Cottrell Anush Sridharan Samantha M. Fix Orrin Thayer Julie M. Long Daria J. Hazuda Paul A. Dayton Russell J. Mumper Angela D. M. Kashuba J. Victor Garcia Ultra-long-acting tunable biodegradable and removable controlled release implants for drug delivery Nature Communications |
| author_facet |
S. Rahima Benhabbour Martina Kovarova Clinton Jones Daijha J. Copeland Roopali Shrivastava Michael D. Swanson Craig Sykes Phong T. Ho Mackenzie L. Cottrell Anush Sridharan Samantha M. Fix Orrin Thayer Julie M. Long Daria J. Hazuda Paul A. Dayton Russell J. Mumper Angela D. M. Kashuba J. Victor Garcia |
| author_sort |
S. Rahima Benhabbour |
| title |
Ultra-long-acting tunable biodegradable and removable controlled release implants for drug delivery |
| title_short |
Ultra-long-acting tunable biodegradable and removable controlled release implants for drug delivery |
| title_full |
Ultra-long-acting tunable biodegradable and removable controlled release implants for drug delivery |
| title_fullStr |
Ultra-long-acting tunable biodegradable and removable controlled release implants for drug delivery |
| title_full_unstemmed |
Ultra-long-acting tunable biodegradable and removable controlled release implants for drug delivery |
| title_sort |
ultra-long-acting tunable biodegradable and removable controlled release implants for drug delivery |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2019-09-01 |
| description |
Patient drug regime compliance is a major issue; sustained release implants could address this. Here, the authors report on a phase inverted in situ forming implant of PLGA for the sustained release of antiretroviral drugs and optimize and demonstrate the release of 6 different drugs over a period of up to a year. |
| url |
https://doi.org/10.1038/s41467-019-12141-5 |
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