Aldose Reductase Acts as a Selective Derepressor of PPARγ and the Retinoic Acid Receptor

Aldose Reductase Acts as a Selective Derepressor of PPARγ and the Retinoic Acid Receptor

Histone deacetylase 3 (HDAC3), a chromatin-modifying enzyme, requires association with the deacetylase-containing domain (DAD) of the nuclear receptor corepressors NCOR1 and SMRT for its stability and activity. Here, we show that aldose reductase (AR), the rate-limiting enzyme of the polyol pathway,...

Full description

Bibliographic Details
Main Authors: Devi Thiagarajan, Radha Ananthakrishnan, Jinghua Zhang, Karen M. O’Shea, Nosirudeen Quadri, Qing Li, Kelli Sas, Xiao Jing, Rosa Rosario, Subramaniam Pennathur, Ann Marie Schmidt, Ravichandran Ramasamy
Format: Article
Language:English
Published: Elsevier 2016-04-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716302212

Similar Items

Similar Items