Inflammasome and Mitophagy Connection in Health and Disease
The inflammasome is a large intracellular protein complex that activates inflammatory caspase-1 and induces the maturation of interleukin (IL)-1β and IL-18. Mitophagy plays an essential role in the maintenance of mitochondrial homeostasis during stress. Previous studies have indicated compelling evi...
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doaj-8bcfd4d764cf48c6ae562990374a006c2020-11-25T03:30:17ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-07-01214714471410.3390/ijms21134714Inflammasome and Mitophagy Connection in Health and DiseaseJae-Min Yuk0Prashanta Silwal1Eun-Kyeong Jo2Department of Infection Biology, Chungnam National University School of Medicine, Daejeon 35015, KoreaInfection Control Convergence Research Center, Chungnam National University School of Medicine, Daejeon 35015, KoreaInfection Control Convergence Research Center, Chungnam National University School of Medicine, Daejeon 35015, KoreaThe inflammasome is a large intracellular protein complex that activates inflammatory caspase-1 and induces the maturation of interleukin (IL)-1β and IL-18. Mitophagy plays an essential role in the maintenance of mitochondrial homeostasis during stress. Previous studies have indicated compelling evidence of the crosstalk between inflammasome and mitophagy. Mitophagy regulation of the inflammasome, or vice versa, is crucial for various biological functions, such as controlling inflammation and metabolism, immune and anti-tumor responses, and pyroptotic cell death. Uncontrolled regulation of the inflammasome often results in pathological inflammation and pyroptosis, and causes a variety of human diseases, including metabolic and inflammatory diseases, infection, and cancer. Here, we discuss how improved understanding of the interactions between inflammasome and mitophagy can lead to novel therapies against various disease pathologies, and how the inflammasome-mitophagy connection is currently being targeted pharmacologically by diverse agents and small molecules. A deeper understanding of the inflammasome-mitophagy connection will provide new insights into human health and disease through the balance between mitochondrial clearance and pathology.https://www.mdpi.com/1422-0067/21/13/4714mitophagyinflammasomeinflammationinfection |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jae-Min Yuk Prashanta Silwal Eun-Kyeong Jo |
spellingShingle |
Jae-Min Yuk Prashanta Silwal Eun-Kyeong Jo Inflammasome and Mitophagy Connection in Health and Disease International Journal of Molecular Sciences mitophagy inflammasome inflammation infection |
author_facet |
Jae-Min Yuk Prashanta Silwal Eun-Kyeong Jo |
author_sort |
Jae-Min Yuk |
title |
Inflammasome and Mitophagy Connection in Health and Disease |
title_short |
Inflammasome and Mitophagy Connection in Health and Disease |
title_full |
Inflammasome and Mitophagy Connection in Health and Disease |
title_fullStr |
Inflammasome and Mitophagy Connection in Health and Disease |
title_full_unstemmed |
Inflammasome and Mitophagy Connection in Health and Disease |
title_sort |
inflammasome and mitophagy connection in health and disease |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1661-6596 1422-0067 |
publishDate |
2020-07-01 |
description |
The inflammasome is a large intracellular protein complex that activates inflammatory caspase-1 and induces the maturation of interleukin (IL)-1β and IL-18. Mitophagy plays an essential role in the maintenance of mitochondrial homeostasis during stress. Previous studies have indicated compelling evidence of the crosstalk between inflammasome and mitophagy. Mitophagy regulation of the inflammasome, or vice versa, is crucial for various biological functions, such as controlling inflammation and metabolism, immune and anti-tumor responses, and pyroptotic cell death. Uncontrolled regulation of the inflammasome often results in pathological inflammation and pyroptosis, and causes a variety of human diseases, including metabolic and inflammatory diseases, infection, and cancer. Here, we discuss how improved understanding of the interactions between inflammasome and mitophagy can lead to novel therapies against various disease pathologies, and how the inflammasome-mitophagy connection is currently being targeted pharmacologically by diverse agents and small molecules. A deeper understanding of the inflammasome-mitophagy connection will provide new insights into human health and disease through the balance between mitochondrial clearance and pathology. |
topic |
mitophagy inflammasome inflammation infection |
url |
https://www.mdpi.com/1422-0067/21/13/4714 |
work_keys_str_mv |
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