Adult-Type Rhabdomyoma of the Larynx: Clinicopathologic Study of an Uncommon Tumor in a Rare Location
Rhabdomyoma is an uncommon benign mesenchymal tumor with skeletal muscle differentiation that may occur either in the heart or in extracardiac sites. Even though the head and neck region is the most common area of extracardiac rhabdomyoma, the larynx is rarely involved. We present the case of an 85-...
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doaj-8be03191c77a4f568d8e8e1fa9b188e82020-11-24T20:44:46ZengHindawi LimitedCase Reports in Otolaryngology2090-67652090-67732017-01-01201710.1155/2017/71867687186768Adult-Type Rhabdomyoma of the Larynx: Clinicopathologic Study of an Uncommon Tumor in a Rare LocationGiancarlo Altissimi0Massimo Ralli1Giulio Sementilli2Francesco Fiorentino3Andrea Ciofalo4Antonio Greco5Marco de Vincentiis6Alessandro Corsi7Giancarlo Cianfrone8Department of Sense Organs, Sapienza University of Rome, Rome, ItalyDepartment of Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, ItalyDepartment of Sense Organs, Sapienza University of Rome, Rome, ItalyDepartment of Molecular Medicine, Sapienza University of Rome, Rome, ItalyDepartment of Sense Organs, Sapienza University of Rome, Rome, ItalyDepartment of Sense Organs, Sapienza University of Rome, Rome, ItalyDepartment of Sense Organs, Sapienza University of Rome, Rome, ItalyDepartment of Molecular Medicine, Sapienza University of Rome, Rome, ItalyDepartment of Sense Organs, Sapienza University of Rome, Rome, ItalyRhabdomyoma is an uncommon benign mesenchymal tumor with skeletal muscle differentiation that may occur either in the heart or in extracardiac sites. Even though the head and neck region is the most common area of extracardiac rhabdomyoma, the larynx is rarely involved. We present the case of an 85-year-old woman who reported a 10-day history of breathing difficulties, dysphagia, and dysphonia. A computed tomography scan of the head and neck showed a contrast-enhanced, solid hypopharyngeal-laryngeal neoplasm with well-defined margins causing subtotal obliteration of the right pyriform sinus and a reduction in air lumen of the laryngeal vestibule. The patient underwent complete endoscopic removal of the lesion; histologic examination revealed an adult-type rhabdomyoma based on the histologic features and the immunoreactivity of the neoplastic cells for desmin, myoglobin, and muscle-specific actin but not for cytokeratin, S-100, CD68R, chromogranin-A, and synaptophysin. Since clinical and imaging features are not specific for rhabdomyoma, histologic examination and immunohistochemical analyses play a central role in the differential diagnosis of the adult-type rhabdomyoma from other laryngeal neoplasms. A correct diagnosis is mandatory to avoid inappropriate treatment.http://dx.doi.org/10.1155/2017/7186768 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Giancarlo Altissimi Massimo Ralli Giulio Sementilli Francesco Fiorentino Andrea Ciofalo Antonio Greco Marco de Vincentiis Alessandro Corsi Giancarlo Cianfrone |
spellingShingle |
Giancarlo Altissimi Massimo Ralli Giulio Sementilli Francesco Fiorentino Andrea Ciofalo Antonio Greco Marco de Vincentiis Alessandro Corsi Giancarlo Cianfrone Adult-Type Rhabdomyoma of the Larynx: Clinicopathologic Study of an Uncommon Tumor in a Rare Location Case Reports in Otolaryngology |
author_facet |
Giancarlo Altissimi Massimo Ralli Giulio Sementilli Francesco Fiorentino Andrea Ciofalo Antonio Greco Marco de Vincentiis Alessandro Corsi Giancarlo Cianfrone |
author_sort |
Giancarlo Altissimi |
title |
Adult-Type Rhabdomyoma of the Larynx: Clinicopathologic Study of an Uncommon Tumor in a Rare Location |
title_short |
Adult-Type Rhabdomyoma of the Larynx: Clinicopathologic Study of an Uncommon Tumor in a Rare Location |
title_full |
Adult-Type Rhabdomyoma of the Larynx: Clinicopathologic Study of an Uncommon Tumor in a Rare Location |
title_fullStr |
Adult-Type Rhabdomyoma of the Larynx: Clinicopathologic Study of an Uncommon Tumor in a Rare Location |
title_full_unstemmed |
Adult-Type Rhabdomyoma of the Larynx: Clinicopathologic Study of an Uncommon Tumor in a Rare Location |
title_sort |
adult-type rhabdomyoma of the larynx: clinicopathologic study of an uncommon tumor in a rare location |
publisher |
Hindawi Limited |
series |
Case Reports in Otolaryngology |
issn |
2090-6765 2090-6773 |
publishDate |
2017-01-01 |
description |
Rhabdomyoma is an uncommon benign mesenchymal tumor with skeletal muscle differentiation that may occur either in the heart or in extracardiac sites. Even though the head and neck region is the most common area of extracardiac rhabdomyoma, the larynx is rarely involved. We present the case of an 85-year-old woman who reported a 10-day history of breathing difficulties, dysphagia, and dysphonia. A computed tomography scan of the head and neck showed a contrast-enhanced, solid hypopharyngeal-laryngeal neoplasm with well-defined margins causing subtotal obliteration of the right pyriform sinus and a reduction in air lumen of the laryngeal vestibule. The patient underwent complete endoscopic removal of the lesion; histologic examination revealed an adult-type rhabdomyoma based on the histologic features and the immunoreactivity of the neoplastic cells for desmin, myoglobin, and muscle-specific actin but not for cytokeratin, S-100, CD68R, chromogranin-A, and synaptophysin. Since clinical and imaging features are not specific for rhabdomyoma, histologic examination and immunohistochemical analyses play a central role in the differential diagnosis of the adult-type rhabdomyoma from other laryngeal neoplasms. A correct diagnosis is mandatory to avoid inappropriate treatment. |
url |
http://dx.doi.org/10.1155/2017/7186768 |
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