Epigenetic Regulation of Inflammatory Responses in the Context of Physical Activity
Epigenetic modifications occur in response to environmental changes and play a fundamental role in the regulation of gene expression. PA is found to elicit an inflammatory response, both from the innate and adaptive divisions of the immunological system. The inflammatory reaction is considered a vit...
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doaj-8be29d0643c846bd9ced6fb4b711afbd2021-09-26T00:12:55ZengMDPI AGGenes2073-44252021-08-01121313131310.3390/genes12091313Epigenetic Regulation of Inflammatory Responses in the Context of Physical ActivityMaciej Tarnowski0Patrycja Kopytko1Katarzyna Piotrowska2Department of Physiology, Pomeranian Medical University in Szczecin, 70-111 Szczecin, PolandDepartment of Physiology, Pomeranian Medical University in Szczecin, 70-111 Szczecin, PolandDepartment of Physiology, Pomeranian Medical University in Szczecin, 70-111 Szczecin, PolandEpigenetic modifications occur in response to environmental changes and play a fundamental role in the regulation of gene expression. PA is found to elicit an inflammatory response, both from the innate and adaptive divisions of the immunological system. The inflammatory reaction is considered a vital trigger of epigenetic changes that in turn modulate inflammatory actions. The tissue responses to PA involve local and general changes. The epigenetic mechanisms involved include: DNA methylation, histone proteins modification and microRNA. All of them affect genetic expression in an inflammatory milieu in physical exercise depending on the magnitude of physiological stress experienced by the exerciser. PA may evoke acute or chronic biochemical and physiological responses and have a positive or negative immunomodulatory effect.https://www.mdpi.com/2073-4425/12/9/1313epigeneticsmiRNAphysical activityexerciseinflammation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Maciej Tarnowski Patrycja Kopytko Katarzyna Piotrowska |
spellingShingle |
Maciej Tarnowski Patrycja Kopytko Katarzyna Piotrowska Epigenetic Regulation of Inflammatory Responses in the Context of Physical Activity Genes epigenetics miRNA physical activity exercise inflammation |
author_facet |
Maciej Tarnowski Patrycja Kopytko Katarzyna Piotrowska |
author_sort |
Maciej Tarnowski |
title |
Epigenetic Regulation of Inflammatory Responses in the Context of Physical Activity |
title_short |
Epigenetic Regulation of Inflammatory Responses in the Context of Physical Activity |
title_full |
Epigenetic Regulation of Inflammatory Responses in the Context of Physical Activity |
title_fullStr |
Epigenetic Regulation of Inflammatory Responses in the Context of Physical Activity |
title_full_unstemmed |
Epigenetic Regulation of Inflammatory Responses in the Context of Physical Activity |
title_sort |
epigenetic regulation of inflammatory responses in the context of physical activity |
publisher |
MDPI AG |
series |
Genes |
issn |
2073-4425 |
publishDate |
2021-08-01 |
description |
Epigenetic modifications occur in response to environmental changes and play a fundamental role in the regulation of gene expression. PA is found to elicit an inflammatory response, both from the innate and adaptive divisions of the immunological system. The inflammatory reaction is considered a vital trigger of epigenetic changes that in turn modulate inflammatory actions. The tissue responses to PA involve local and general changes. The epigenetic mechanisms involved include: DNA methylation, histone proteins modification and microRNA. All of them affect genetic expression in an inflammatory milieu in physical exercise depending on the magnitude of physiological stress experienced by the exerciser. PA may evoke acute or chronic biochemical and physiological responses and have a positive or negative immunomodulatory effect. |
topic |
epigenetics miRNA physical activity exercise inflammation |
url |
https://www.mdpi.com/2073-4425/12/9/1313 |
work_keys_str_mv |
AT maciejtarnowski epigeneticregulationofinflammatoryresponsesinthecontextofphysicalactivity AT patrycjakopytko epigeneticregulationofinflammatoryresponsesinthecontextofphysicalactivity AT katarzynapiotrowska epigeneticregulationofinflammatoryresponsesinthecontextofphysicalactivity |
_version_ |
1717366688110870528 |