Astrocytic Response to Acutely- and Chronically-Implanted Microelectrode Arrays in the Marmoset (<i>Callithrix jacchus</i>) Brain
Microelectrode implants are an important tool in neuroscience research and in developing brain⁻machine interfaces. Data from rodents have consistently shown that astrocytes are recruited to the area surrounding implants, forming a glial scar that increases electrode impedance and reduces c...
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doaj-8bee17c0adf9474c80d5e261897502682020-11-25T00:10:47ZengMDPI AGBrain Sciences2076-34252019-01-01921910.3390/brainsci9020019brainsci9020019Astrocytic Response to Acutely- and Chronically-Implanted Microelectrode Arrays in the Marmoset (<i>Callithrix jacchus</i>) BrainSamuel A. Budoff0Kim M. Yano1Fernanda C. de Mesquita2Jhulimar G. Doerl3Maxwell B. de Santana4Manuela S. L. Nascimento5Ana Carolina B. Kunicki6Mariana F. P. de Araújo7Edmond and Lily Safra International Institute of Neuroscience, Santos Dumont Institute, Macaíba, RN 59280-000, BrazilEdmond and Lily Safra International Institute of Neuroscience, Santos Dumont Institute, Macaíba, RN 59280-000, BrazilEdmond and Lily Safra International Institute of Neuroscience, Santos Dumont Institute, Macaíba, RN 59280-000, BrazilEdmond and Lily Safra International Institute of Neuroscience, Santos Dumont Institute, Macaíba, RN 59280-000, BrazilInstitute for Science and Technology of Water (ICTA), Federal University of Western Pará, Santarém, Pará 68040-255, BrazilEdmond and Lily Safra International Institute of Neuroscience, Santos Dumont Institute, Macaíba, RN 59280-000, BrazilEdmond and Lily Safra International Institute of Neuroscience, Santos Dumont Institute, Macaíba, RN 59280-000, BrazilEdmond and Lily Safra International Institute of Neuroscience, Santos Dumont Institute, Macaíba, RN 59280-000, BrazilMicroelectrode implants are an important tool in neuroscience research and in developing brain⁻machine interfaces. Data from rodents have consistently shown that astrocytes are recruited to the area surrounding implants, forming a glial scar that increases electrode impedance and reduces chronic utility. However, studies in non-human primates are scarce, with none to date in marmosets. We used glial fibrillary acidic protein (GFAP) immunostaining to characterize the acute and chronic response of the marmoset brain to microelectrodes. By using densitometry, we showed that marmoset astrocytes surround brain implants and that a glial scar is formed over time, with significant increase in the chronic condition relative to the acute condition animal.https://www.mdpi.com/2076-3425/9/2/19gliosismarmosetmicroelectrodeastrocyte |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Samuel A. Budoff Kim M. Yano Fernanda C. de Mesquita Jhulimar G. Doerl Maxwell B. de Santana Manuela S. L. Nascimento Ana Carolina B. Kunicki Mariana F. P. de Araújo |
spellingShingle |
Samuel A. Budoff Kim M. Yano Fernanda C. de Mesquita Jhulimar G. Doerl Maxwell B. de Santana Manuela S. L. Nascimento Ana Carolina B. Kunicki Mariana F. P. de Araújo Astrocytic Response to Acutely- and Chronically-Implanted Microelectrode Arrays in the Marmoset (<i>Callithrix jacchus</i>) Brain Brain Sciences gliosis marmoset microelectrode astrocyte |
author_facet |
Samuel A. Budoff Kim M. Yano Fernanda C. de Mesquita Jhulimar G. Doerl Maxwell B. de Santana Manuela S. L. Nascimento Ana Carolina B. Kunicki Mariana F. P. de Araújo |
author_sort |
Samuel A. Budoff |
title |
Astrocytic Response to Acutely- and Chronically-Implanted Microelectrode Arrays in the Marmoset (<i>Callithrix jacchus</i>) Brain |
title_short |
Astrocytic Response to Acutely- and Chronically-Implanted Microelectrode Arrays in the Marmoset (<i>Callithrix jacchus</i>) Brain |
title_full |
Astrocytic Response to Acutely- and Chronically-Implanted Microelectrode Arrays in the Marmoset (<i>Callithrix jacchus</i>) Brain |
title_fullStr |
Astrocytic Response to Acutely- and Chronically-Implanted Microelectrode Arrays in the Marmoset (<i>Callithrix jacchus</i>) Brain |
title_full_unstemmed |
Astrocytic Response to Acutely- and Chronically-Implanted Microelectrode Arrays in the Marmoset (<i>Callithrix jacchus</i>) Brain |
title_sort |
astrocytic response to acutely- and chronically-implanted microelectrode arrays in the marmoset (<i>callithrix jacchus</i>) brain |
publisher |
MDPI AG |
series |
Brain Sciences |
issn |
2076-3425 |
publishDate |
2019-01-01 |
description |
Microelectrode implants are an important tool in neuroscience research and in developing brain⁻machine interfaces. Data from rodents have consistently shown that astrocytes are recruited to the area surrounding implants, forming a glial scar that increases electrode impedance and reduces chronic utility. However, studies in non-human primates are scarce, with none to date in marmosets. We used glial fibrillary acidic protein (GFAP) immunostaining to characterize the acute and chronic response of the marmoset brain to microelectrodes. By using densitometry, we showed that marmoset astrocytes surround brain implants and that a glial scar is formed over time, with significant increase in the chronic condition relative to the acute condition animal. |
topic |
gliosis marmoset microelectrode astrocyte |
url |
https://www.mdpi.com/2076-3425/9/2/19 |
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