Astrocytic Response to Acutely- and Chronically-Implanted Microelectrode Arrays in the Marmoset (<i>Callithrix jacchus</i>) Brain

Microelectrode implants are an important tool in neuroscience research and in developing brain⁻machine interfaces. Data from rodents have consistently shown that astrocytes are recruited to the area surrounding implants, forming a glial scar that increases electrode impedance and reduces c...

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Main Authors:	Samuel A. Budoff, Kim M. Yano, Fernanda C. de Mesquita, Jhulimar G. Doerl, Maxwell B. de Santana, Manuela S. L. Nascimento, Ana Carolina B. Kunicki, Mariana F. P. de Araújo
Format:	Article
Language:	English
Published:	MDPI AG 2019-01-01
Series:	Brain Sciences
Subjects:	gliosis marmoset microelectrode astrocyte
Online Access:	https://www.mdpi.com/2076-3425/9/2/19

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record_format	Article
spelling	doaj-8bee17c0adf9474c80d5e261897502682020-11-25T00:10:47ZengMDPI AGBrain Sciences2076-34252019-01-01921910.3390/brainsci9020019brainsci9020019Astrocytic Response to Acutely- and Chronically-Implanted Microelectrode Arrays in the Marmoset (<i>Callithrix jacchus</i>) BrainSamuel A. Budoff0Kim M. Yano1Fernanda C. de Mesquita2Jhulimar G. Doerl3Maxwell B. de Santana4Manuela S. L. Nascimento5Ana Carolina B. Kunicki6Mariana F. P. de Araújo7Edmond and Lily Safra International Institute of Neuroscience, Santos Dumont Institute, Macaíba, RN 59280-000, BrazilEdmond and Lily Safra International Institute of Neuroscience, Santos Dumont Institute, Macaíba, RN 59280-000, BrazilEdmond and Lily Safra International Institute of Neuroscience, Santos Dumont Institute, Macaíba, RN 59280-000, BrazilEdmond and Lily Safra International Institute of Neuroscience, Santos Dumont Institute, Macaíba, RN 59280-000, BrazilInstitute for Science and Technology of Water (ICTA), Federal University of Western Pará, Santarém, Pará 68040-255, BrazilEdmond and Lily Safra International Institute of Neuroscience, Santos Dumont Institute, Macaíba, RN 59280-000, BrazilEdmond and Lily Safra International Institute of Neuroscience, Santos Dumont Institute, Macaíba, RN 59280-000, BrazilEdmond and Lily Safra International Institute of Neuroscience, Santos Dumont Institute, Macaíba, RN 59280-000, BrazilMicroelectrode implants are an important tool in neuroscience research and in developing brain⁻machine interfaces. Data from rodents have consistently shown that astrocytes are recruited to the area surrounding implants, forming a glial scar that increases electrode impedance and reduces chronic utility. However, studies in non-human primates are scarce, with none to date in marmosets. We used glial fibrillary acidic protein (GFAP) immunostaining to characterize the acute and chronic response of the marmoset brain to microelectrodes. By using densitometry, we showed that marmoset astrocytes surround brain implants and that a glial scar is formed over time, with significant increase in the chronic condition relative to the acute condition animal.https://www.mdpi.com/2076-3425/9/2/19gliosismarmosetmicroelectrodeastrocyte
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Samuel A. Budoff Kim M. Yano Fernanda C. de Mesquita Jhulimar G. Doerl Maxwell B. de Santana Manuela S. L. Nascimento Ana Carolina B. Kunicki Mariana F. P. de Araújo
spellingShingle	Samuel A. Budoff Kim M. Yano Fernanda C. de Mesquita Jhulimar G. Doerl Maxwell B. de Santana Manuela S. L. Nascimento Ana Carolina B. Kunicki Mariana F. P. de Araújo Astrocytic Response to Acutely- and Chronically-Implanted Microelectrode Arrays in the Marmoset (<i>Callithrix jacchus</i>) Brain Brain Sciences gliosis marmoset microelectrode astrocyte
author_facet	Samuel A. Budoff Kim M. Yano Fernanda C. de Mesquita Jhulimar G. Doerl Maxwell B. de Santana Manuela S. L. Nascimento Ana Carolina B. Kunicki Mariana F. P. de Araújo
author_sort	Samuel A. Budoff
title	Astrocytic Response to Acutely- and Chronically-Implanted Microelectrode Arrays in the Marmoset (<i>Callithrix jacchus</i>) Brain
title_short	Astrocytic Response to Acutely- and Chronically-Implanted Microelectrode Arrays in the Marmoset (<i>Callithrix jacchus</i>) Brain
title_full	Astrocytic Response to Acutely- and Chronically-Implanted Microelectrode Arrays in the Marmoset (<i>Callithrix jacchus</i>) Brain
title_fullStr	Astrocytic Response to Acutely- and Chronically-Implanted Microelectrode Arrays in the Marmoset (<i>Callithrix jacchus</i>) Brain
title_full_unstemmed	Astrocytic Response to Acutely- and Chronically-Implanted Microelectrode Arrays in the Marmoset (<i>Callithrix jacchus</i>) Brain
title_sort	astrocytic response to acutely- and chronically-implanted microelectrode arrays in the marmoset (<i>callithrix jacchus</i>) brain
publisher	MDPI AG
series	Brain Sciences
issn	2076-3425
publishDate	2019-01-01
description	Microelectrode implants are an important tool in neuroscience research and in developing brain⁻machine interfaces. Data from rodents have consistently shown that astrocytes are recruited to the area surrounding implants, forming a glial scar that increases electrode impedance and reduces chronic utility. However, studies in non-human primates are scarce, with none to date in marmosets. We used glial fibrillary acidic protein (GFAP) immunostaining to characterize the acute and chronic response of the marmoset brain to microelectrodes. By using densitometry, we showed that marmoset astrocytes surround brain implants and that a glial scar is formed over time, with significant increase in the chronic condition relative to the acute condition animal.
topic	gliosis marmoset microelectrode astrocyte
url	https://www.mdpi.com/2076-3425/9/2/19
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Astrocytic Response to Acutely- and Chronically-Implanted Microelectrode Arrays in the Marmoset (<i>Callithrix jacchus</i>) Brain

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