H63D CG genotype of HFE is associated with increased risk of sporadic amyotrophic lateral sclerosis in a single population
This paper describes the genetic etiology of sporadic amyotrophic lateral sclerosis in a single population. Polymerase chain reaction-restriction fragment length polymorphism and DNA sample sequencing of 3 common HFE gene variants (C282Y and H63D and S65C) were performed on 10 randomly selected samp...
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2020-09-01
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doaj-8bee3b502a9c49cc83a429df5446d84b2020-12-07T05:12:26ZengIMR (Innovative Medical Research) Press LimitedJournal of Integrative Neuroscience1757-448X2020-09-0119349549910.31083/j.jin.2020.03.131H63D CG genotype of HFE is associated with increased risk of sporadic amyotrophic lateral sclerosis in a single populationQing-Qing Zhang, Hong Jiang, Chun-Yan Li, Ya-Ling Liu, Xin-Ying Tian01Department of Neurology, The Second Hospital of Hebei Medical University, West Heping Road 215, Shijiazhuang, Hebei, 050000, P. R. China;2Department of Neurology, Binzhou Medical University Hospital, Binzhou, Shandong, 256603, P. R. China;3Key Laboratory of Neurology of Hebei Province, Shijiazhuang, Hebei, 050000, P. R. ChinaThis paper describes the genetic etiology of sporadic amyotrophic lateral sclerosis in a single population. Polymerase chain reaction-restriction fragment length polymorphism and DNA sample sequencing of 3 common HFE gene variants (C282Y and H63D and S65C) were performed on 10 randomly selected samples of H63D gene variant (124 patients with sporadic amyotrophic lateral sclerosis) and 10 wild types of H63D samples (210 controls). The C282Y and S65C gene variant were absent. There were 24 cases (7.18%) with H63D heterozygous variants, including 16 cases (13%) in the sporadic amyotrophic lateral sclerosis group and 8 cases (4%) in the healthy control group. The polymorphism frequency of the H63D gene variant in the sporadic amyotrophic lateral sclerosis group was significantly different than that in the control group (p < 0.05), and the difference at allele level, which is still more significant (p < 0.05). H63D gene variant could be a risk factor for sporadic amyotrophic lateral sclerosis in a single population. The results showed HFE gene variants play a role in the occurrence of sporadic amyotrophic lateral sclerosis, but its effect should be carefully estimated.https://jin.imrpress.com/fileup/1757-448X/PDF/1601431118347-1376775326.pdf|neurogenetics|amyotrophic lateral sclerosis|motor neuron disease|hfe gene|polymorphism |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Qing-Qing Zhang, Hong Jiang, Chun-Yan Li, Ya-Ling Liu, Xin-Ying Tian |
spellingShingle |
Qing-Qing Zhang, Hong Jiang, Chun-Yan Li, Ya-Ling Liu, Xin-Ying Tian H63D CG genotype of HFE is associated with increased risk of sporadic amyotrophic lateral sclerosis in a single population Journal of Integrative Neuroscience |neurogenetics|amyotrophic lateral sclerosis|motor neuron disease|hfe gene|polymorphism |
author_facet |
Qing-Qing Zhang, Hong Jiang, Chun-Yan Li, Ya-Ling Liu, Xin-Ying Tian |
author_sort |
Qing-Qing Zhang, Hong Jiang, Chun-Yan Li, Ya-Ling Liu, Xin-Ying Tian |
title |
H63D CG genotype of HFE is associated with increased risk of sporadic amyotrophic lateral sclerosis in a single population |
title_short |
H63D CG genotype of HFE is associated with increased risk of sporadic amyotrophic lateral sclerosis in a single population |
title_full |
H63D CG genotype of HFE is associated with increased risk of sporadic amyotrophic lateral sclerosis in a single population |
title_fullStr |
H63D CG genotype of HFE is associated with increased risk of sporadic amyotrophic lateral sclerosis in a single population |
title_full_unstemmed |
H63D CG genotype of HFE is associated with increased risk of sporadic amyotrophic lateral sclerosis in a single population |
title_sort |
h63d cg genotype of hfe is associated with increased risk of sporadic amyotrophic lateral sclerosis in a single population |
publisher |
IMR (Innovative Medical Research) Press Limited |
series |
Journal of Integrative Neuroscience |
issn |
1757-448X |
publishDate |
2020-09-01 |
description |
This paper describes the genetic etiology of sporadic amyotrophic lateral sclerosis in a single population. Polymerase chain reaction-restriction fragment length polymorphism and DNA sample sequencing of 3 common HFE gene variants (C282Y and H63D and S65C) were performed on 10 randomly selected samples of H63D gene variant (124 patients with sporadic amyotrophic lateral sclerosis) and 10 wild types of H63D samples (210 controls). The C282Y and S65C gene variant were absent. There were 24 cases (7.18%) with H63D heterozygous variants, including 16 cases (13%) in the sporadic amyotrophic lateral sclerosis group and 8 cases (4%) in the healthy control group. The polymorphism frequency of the H63D gene variant in the sporadic amyotrophic lateral sclerosis group was significantly different than that in the control group (p < 0.05), and the difference at allele level, which is still more significant (p < 0.05). H63D gene variant could be a risk factor for sporadic amyotrophic lateral sclerosis in a single population. The results showed HFE gene variants play a role in the occurrence of sporadic amyotrophic lateral sclerosis, but its effect should be carefully estimated. |
topic |
|neurogenetics|amyotrophic lateral sclerosis|motor neuron disease|hfe gene|polymorphism |
url |
https://jin.imrpress.com/fileup/1757-448X/PDF/1601431118347-1376775326.pdf |
work_keys_str_mv |
AT qingqingzhanghongjiangchunyanliyalingliuxinyingtian h63dcggenotypeofhfeisassociatedwithincreasedriskofsporadicamyotrophiclateralsclerosisinasinglepopulation |
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