Prevalence of hypothyroidism in diabetic kidney disease and effect of thyroid hormone replacement on estimate glomerular filtration rate
Aims: To determine the prevalence of subclinical and overt hypothyroidism in diabetic kidney disease (DKD) and effect of thyroid hormone replacement on progression of DKD. Materials and Methods: A prospective cohort study on 41 adult DKD patients who were screened for hypothyroidism. Hypothyroid DKD...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Wolters Kluwer Medknow Publications
2016-01-01
|
Series: | Indian Journal of Endocrinology and Metabolism |
Subjects: | |
Online Access: | http://www.ijem.in/article.asp?issn=2230-8210;year=2016;volume=20;issue=6;spage=795;epage=798;aulast=Bajaj |
id |
doaj-8beea49ce00940ecafc0292cea671f5a |
---|---|
record_format |
Article |
spelling |
doaj-8beea49ce00940ecafc0292cea671f5a2020-11-24T23:04:59ZengWolters Kluwer Medknow PublicationsIndian Journal of Endocrinology and Metabolism2230-82102016-01-0120679579810.4103/2230-8210.192893Prevalence of hypothyroidism in diabetic kidney disease and effect of thyroid hormone replacement on estimate glomerular filtration rateSarita BajajNaincy PurwarArvind GuptaPoonam GuptaAnubha SrivastavaAims: To determine the prevalence of subclinical and overt hypothyroidism in diabetic kidney disease (DKD) and effect of thyroid hormone replacement on progression of DKD. Materials and Methods: A prospective cohort study on 41 adult DKD patients who were screened for hypothyroidism. Hypothyroid DKD patients were started on levothyroxine replacement and were reviewed after 3 and 6 months. Results: Of the total population, 14 (34.1%) cases were hypothyroid, among whom 12 (29.3%) cases were subclinical, and 2 (4.8%) were overt hypothyroidism. Prevalence of hypothyroidism and mean thyroid stimulating hormone levels increased with increasing severity of DKD. There were 2 (14.3%) hypothyroid cases in stage 3b, 4 (28.5%) cases in stage 4, and 8 (57.2%) in stage 5 DKD. The mean estimate glomerular filtration rate (ml/min/1.73 m2) at baseline was 13.6 ± 13.3 which increased to 16.4 ± 14.5 and 21.2 ± 15.3 after 3 and 6 months of thyroid hormone replacement therapy (THRT), respectively (P < 0.001). Conclusions: Hypothyroidism is commonly associated with DKD. Prevalence of hypothyroidism increased with declining renal function. THRT significantly improved renal function in DKD patients with hypothyroidism after 3 and 6 months of therapy.http://www.ijem.in/article.asp?issn=2230-8210;year=2016;volume=20;issue=6;spage=795;epage=798;aulast=BajajDiabetic kidney diseaseestimate glomerular filtration ratehypothyroidism |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sarita Bajaj Naincy Purwar Arvind Gupta Poonam Gupta Anubha Srivastava |
spellingShingle |
Sarita Bajaj Naincy Purwar Arvind Gupta Poonam Gupta Anubha Srivastava Prevalence of hypothyroidism in diabetic kidney disease and effect of thyroid hormone replacement on estimate glomerular filtration rate Indian Journal of Endocrinology and Metabolism Diabetic kidney disease estimate glomerular filtration rate hypothyroidism |
author_facet |
Sarita Bajaj Naincy Purwar Arvind Gupta Poonam Gupta Anubha Srivastava |
author_sort |
Sarita Bajaj |
title |
Prevalence of hypothyroidism in diabetic kidney disease and effect of thyroid hormone replacement on estimate glomerular filtration rate |
title_short |
Prevalence of hypothyroidism in diabetic kidney disease and effect of thyroid hormone replacement on estimate glomerular filtration rate |
title_full |
Prevalence of hypothyroidism in diabetic kidney disease and effect of thyroid hormone replacement on estimate glomerular filtration rate |
title_fullStr |
Prevalence of hypothyroidism in diabetic kidney disease and effect of thyroid hormone replacement on estimate glomerular filtration rate |
title_full_unstemmed |
Prevalence of hypothyroidism in diabetic kidney disease and effect of thyroid hormone replacement on estimate glomerular filtration rate |
title_sort |
prevalence of hypothyroidism in diabetic kidney disease and effect of thyroid hormone replacement on estimate glomerular filtration rate |
publisher |
Wolters Kluwer Medknow Publications |
series |
Indian Journal of Endocrinology and Metabolism |
issn |
2230-8210 |
publishDate |
2016-01-01 |
description |
Aims: To determine the prevalence of subclinical and overt hypothyroidism in diabetic kidney disease (DKD) and effect of thyroid hormone replacement on progression of DKD. Materials and Methods: A prospective cohort study on 41 adult DKD patients who were screened for hypothyroidism. Hypothyroid DKD patients were started on levothyroxine replacement and were reviewed after 3 and 6 months. Results: Of the total population, 14 (34.1%) cases were hypothyroid, among whom 12 (29.3%) cases were subclinical, and 2 (4.8%) were overt hypothyroidism. Prevalence of hypothyroidism and mean thyroid stimulating hormone levels increased with increasing severity of DKD. There were 2 (14.3%) hypothyroid cases in stage 3b, 4 (28.5%) cases in stage 4, and 8 (57.2%) in stage 5 DKD. The mean estimate glomerular filtration rate (ml/min/1.73 m2) at baseline was 13.6 ± 13.3 which increased to 16.4 ± 14.5 and 21.2 ± 15.3 after 3 and 6 months of thyroid hormone replacement therapy (THRT), respectively (P < 0.001). Conclusions: Hypothyroidism is commonly associated with DKD. Prevalence of hypothyroidism increased with declining renal function. THRT significantly improved renal function in DKD patients with hypothyroidism after 3 and 6 months of therapy. |
topic |
Diabetic kidney disease estimate glomerular filtration rate hypothyroidism |
url |
http://www.ijem.in/article.asp?issn=2230-8210;year=2016;volume=20;issue=6;spage=795;epage=798;aulast=Bajaj |
work_keys_str_mv |
AT saritabajaj prevalenceofhypothyroidismindiabetickidneydiseaseandeffectofthyroidhormonereplacementonestimateglomerularfiltrationrate AT naincypurwar prevalenceofhypothyroidismindiabetickidneydiseaseandeffectofthyroidhormonereplacementonestimateglomerularfiltrationrate AT arvindgupta prevalenceofhypothyroidismindiabetickidneydiseaseandeffectofthyroidhormonereplacementonestimateglomerularfiltrationrate AT poonamgupta prevalenceofhypothyroidismindiabetickidneydiseaseandeffectofthyroidhormonereplacementonestimateglomerularfiltrationrate AT anubhasrivastava prevalenceofhypothyroidismindiabetickidneydiseaseandeffectofthyroidhormonereplacementonestimateglomerularfiltrationrate |
_version_ |
1725628066202386432 |