MOLECULAR MECHANISMS OF PLURIPOTENCY INDUCTION AND REPROGRAMMING OF SOMATIC CELLS
To analyze the recent studies elucidating the molecular mechanisms of pluripotency induction and crucial stages of the reprogramming process was the aim of the review. The key focus is on the factors enabling switch between the reprogramming stages. It is concluded that one of the key barriers for i...
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National Academy of Sciences of Ukraine and Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine.
2017-02-01
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Online Access: | http://biotechnology.kiev.ua/images/1_2017/deputatova_1_2017.pdf |
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doaj-8bf29a3965eb41048e61392a6c0e25062020-11-24T20:41:42ZengNational Academy of Sciences of Ukraine and Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine.Biotechnologia Acta2410-77512410-776X2017-02-01101172510.15407/biotech10.01.017MOLECULAR MECHANISMS OF PLURIPOTENCY INDUCTION AND REPROGRAMMING OF SOMATIC CELLST. O. Deputatova0De Novo, LLC, Kyiv, UkraineTo analyze the recent studies elucidating the molecular mechanisms of pluripotency induction and crucial stages of the reprogramming process was the aim of the review. The key focus is on the factors enabling switch between the reprogramming stages. It is concluded that one of the key barriers for iPSC applications is the multi-stage nature of somatic cells reprogramming that features both stochastic early phases and deterministic establishment of pluripotent regulatory network. Despite thousands of scientific studies, various reprogramming protocols restrict effective research analysis and identification of molecular reprogramming mechanisms. In order to specify accurate reprogramming algorithms and develop more effective protocols of patient specific reprogrammed cells cultivation, the future researches require focus on the phase transition switchers.http://biotechnology.kiev.ua/images/1_2017/deputatova_1_2017.pdfpluripotency inductionreprogrammingsomatic cellsinduced pluripotent stem cells |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
T. O. Deputatova |
spellingShingle |
T. O. Deputatova MOLECULAR MECHANISMS OF PLURIPOTENCY INDUCTION AND REPROGRAMMING OF SOMATIC CELLS Biotechnologia Acta pluripotency induction reprogramming somatic cells induced pluripotent stem cells |
author_facet |
T. O. Deputatova |
author_sort |
T. O. Deputatova |
title |
MOLECULAR MECHANISMS OF PLURIPOTENCY INDUCTION AND REPROGRAMMING OF SOMATIC CELLS |
title_short |
MOLECULAR MECHANISMS OF PLURIPOTENCY INDUCTION AND REPROGRAMMING OF SOMATIC CELLS |
title_full |
MOLECULAR MECHANISMS OF PLURIPOTENCY INDUCTION AND REPROGRAMMING OF SOMATIC CELLS |
title_fullStr |
MOLECULAR MECHANISMS OF PLURIPOTENCY INDUCTION AND REPROGRAMMING OF SOMATIC CELLS |
title_full_unstemmed |
MOLECULAR MECHANISMS OF PLURIPOTENCY INDUCTION AND REPROGRAMMING OF SOMATIC CELLS |
title_sort |
molecular mechanisms of pluripotency induction and reprogramming of somatic cells |
publisher |
National Academy of Sciences of Ukraine and Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine. |
series |
Biotechnologia Acta |
issn |
2410-7751 2410-776X |
publishDate |
2017-02-01 |
description |
To analyze the recent studies elucidating the molecular mechanisms of pluripotency induction and crucial stages of the reprogramming process was the aim of the review. The key focus is on the factors enabling switch between the reprogramming stages. It is concluded that one of the key barriers for iPSC applications is the multi-stage nature of somatic cells reprogramming that features both stochastic early phases and deterministic establishment of pluripotent regulatory network. Despite thousands of scientific studies, various reprogramming protocols restrict effective research analysis and identification of molecular reprogramming mechanisms. In order to specify accurate reprogramming algorithms and develop more effective protocols of patient specific reprogrammed cells cultivation, the future researches require focus on the phase transition switchers. |
topic |
pluripotency induction reprogramming somatic cells induced pluripotent stem cells |
url |
http://biotechnology.kiev.ua/images/1_2017/deputatova_1_2017.pdf |
work_keys_str_mv |
AT todeputatova molecularmechanismsofpluripotencyinductionandreprogrammingofsomaticcells |
_version_ |
1716824138092380160 |