ON THE CYTOTOXICITY OF ORTHODONTIC ARCHES IN HUMAN FIBROBLAST CULTURES
The present study analyzes the orthodontic nickel-titanium alloy with orthodontic shape memory (Niti GAC arches, Nitinol 3M arches, Beta Titanium 3M arches) from the viewpoint of its cytotoxicity. Apart from the intrinsic toxicity of the metals upon cells, corrosion may dramatically alter the behavi...
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doaj-8bfcb551a3ce4984b8cd898d9c90c3072020-11-25T01:59:24ZengAcademy of Romanian ScientistsInternational Journal of Medical Dentistry2066-60632066-60632015-12-015(19)4237328ON THE CYTOTOXICITY OF ORTHODONTIC ARCHES IN HUMAN FIBROBLAST CULTURESLiliana-Gabriela HALIŢCHI0Oana-Maria DARABĂ1Irina-Paula MERLUŞCĂ2Codruța ILIESCU3Ionuț CHIRAP4Vasile BURLUI5Assist. Prof., PhD, Faculty of Medical Dentistry, “Apollonia” University of IaşiAssist. Prof., PhD, Faculty of Medical Dentistry, “Apollonia” University of IaşiUniv. Assist., Faculty of Medical Dentistry, “Apollonia” University of Iaşi; PhD student, Faculty of Chemical Engineering and Environmental Protection, “Gheorghe Asachi” Technical University of IaşiUniv. Assist., PhD, Faculty of Medicine, “Gr. T. Popa” University of Medicine and Pharmacy, IasiPhD Student, Faculty of Physics, “Alexandru Ioan Cuza” University of IasiProf. PhD, Faculty of Medical Dentistry, “Apollonia” University of IaşiThe present study analyzes the orthodontic nickel-titanium alloy with orthodontic shape memory (Niti GAC arches, Nitinol 3M arches, Beta Titanium 3M arches) from the viewpoint of its cytotoxicity. Apart from the intrinsic toxicity of the metals upon cells, corrosion may dramatically alter the behaviour of alloys, as evidenced by the in vitro and in vivo studies developed in the field. Due to the high and variable nickel content, its is possible that, at least theoretically, the released ions should produce – as a result of intraoral corrosion – secondary effects, which makes necessary to assert the cytotoxicity of NiTi alloys prior to their safe utilizationor in the oral cavity of children and young patients. Evaluation of cell morphology and determination of cell viability, following exposure to the 3 types of orthodontic materials, evidenced no toxic reactions. Several problems are still to be elucidated, related to the consequences of the surface conditions, of the dissolution and in vivo release of the nickel ions after a longer treatment, of the accumulations of ion traces, of the response of the dental-periodontal tissues, of the effects manifested at cell and molecular level. Apart from the intrisic toxicity of metals upon cells, corrosion may dramatically influence the behaviour of alloys under in vitro conditions, comparatively with the in vivo ones, the nitinol samples being biologically safe. http://www.ijmd.ro/articole/456_08%20Liliana-Gabriela%20HALITCHI.pdfbehaviourorthodontic alloysnitinolcytotoxicitycell culturescorrosion |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Liliana-Gabriela HALIŢCHI Oana-Maria DARABĂ Irina-Paula MERLUŞCĂ Codruța ILIESCU Ionuț CHIRAP Vasile BURLUI |
spellingShingle |
Liliana-Gabriela HALIŢCHI Oana-Maria DARABĂ Irina-Paula MERLUŞCĂ Codruța ILIESCU Ionuț CHIRAP Vasile BURLUI ON THE CYTOTOXICITY OF ORTHODONTIC ARCHES IN HUMAN FIBROBLAST CULTURES International Journal of Medical Dentistry behaviour orthodontic alloys nitinol cytotoxicity cell cultures corrosion |
author_facet |
Liliana-Gabriela HALIŢCHI Oana-Maria DARABĂ Irina-Paula MERLUŞCĂ Codruța ILIESCU Ionuț CHIRAP Vasile BURLUI |
author_sort |
Liliana-Gabriela HALIŢCHI |
title |
ON THE CYTOTOXICITY OF ORTHODONTIC ARCHES IN HUMAN FIBROBLAST CULTURES |
title_short |
ON THE CYTOTOXICITY OF ORTHODONTIC ARCHES IN HUMAN FIBROBLAST CULTURES |
title_full |
ON THE CYTOTOXICITY OF ORTHODONTIC ARCHES IN HUMAN FIBROBLAST CULTURES |
title_fullStr |
ON THE CYTOTOXICITY OF ORTHODONTIC ARCHES IN HUMAN FIBROBLAST CULTURES |
title_full_unstemmed |
ON THE CYTOTOXICITY OF ORTHODONTIC ARCHES IN HUMAN FIBROBLAST CULTURES |
title_sort |
on the cytotoxicity of orthodontic arches in human fibroblast cultures |
publisher |
Academy of Romanian Scientists |
series |
International Journal of Medical Dentistry |
issn |
2066-6063 2066-6063 |
publishDate |
2015-12-01 |
description |
The present study analyzes the orthodontic nickel-titanium alloy with orthodontic shape memory (Niti GAC arches, Nitinol 3M arches, Beta Titanium 3M arches) from the viewpoint of its cytotoxicity. Apart from the intrinsic toxicity of the metals upon cells, corrosion may dramatically alter the behaviour of alloys, as evidenced by the in vitro and in vivo studies developed in the field. Due to the high and variable nickel content, its is possible that, at least theoretically, the released ions should produce – as a result of intraoral corrosion – secondary effects, which makes necessary to assert the cytotoxicity of NiTi alloys prior to their safe utilizationor in the oral cavity of children and young patients.
Evaluation of cell morphology and determination of cell viability, following exposure to the 3 types of orthodontic materials, evidenced no toxic reactions. Several problems are still to be elucidated, related to the consequences of the surface conditions, of the dissolution and in vivo release of the nickel ions after a longer treatment, of the accumulations of ion traces, of the response of the dental-periodontal tissues, of the effects manifested at cell and molecular level. Apart from the intrisic toxicity of metals upon cells, corrosion may dramatically influence the behaviour of alloys under in vitro conditions, comparatively with the in vivo ones, the nitinol samples being biologically safe.
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topic |
behaviour orthodontic alloys nitinol cytotoxicity cell cultures corrosion |
url |
http://www.ijmd.ro/articole/456_08%20Liliana-Gabriela%20HALITCHI.pdf |
work_keys_str_mv |
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