Mechanisms by Which Kinesin-5 Motors Perform Their Multiple Intracellular Functions

Mechanisms by Which Kinesin-5 Motors Perform Their Multiple Intracellular Functions

Bipolar kinesin-5 motor proteins perform multiple intracellular functions, mainly during mitotic cell division. Their specialized structural characteristics enable these motors to perform their essential functions by crosslinking and sliding apart antiparallel microtubules (MTs). In this review, we...

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Bibliographic Details
Main Authors: Himanshu Pandey, Mary Popov, Alina Goldstein-Levitin, Larisa Gheber
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
kinesin-5
microtubules
mitosis
cell-cycle regulation of kinesin activity
Online Access:https://www.mdpi.com/1422-0067/22/12/6420
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spelling doaj-8c01aa62d0ba4815aa22f759e99217a72021-07-01T00:16:26ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-06-01226420642010.3390/ijms22126420Mechanisms by Which Kinesin-5 Motors Perform Their Multiple Intracellular FunctionsHimanshu Pandey0Mary Popov1Alina Goldstein-Levitin2Larisa Gheber3Department of Chemistry and Ilse Katz Institute for Nanoscale Science and Technology, Ben-Gurion University of the Negev, P.O. Box 653, Beer-Sheva 84105, IsraelDepartment of Chemistry and Ilse Katz Institute for Nanoscale Science and Technology, Ben-Gurion University of the Negev, P.O. Box 653, Beer-Sheva 84105, IsraelDepartment of Chemistry and Ilse Katz Institute for Nanoscale Science and Technology, Ben-Gurion University of the Negev, P.O. Box 653, Beer-Sheva 84105, IsraelDepartment of Chemistry and Ilse Katz Institute for Nanoscale Science and Technology, Ben-Gurion University of the Negev, P.O. Box 653, Beer-Sheva 84105, IsraelBipolar kinesin-5 motor proteins perform multiple intracellular functions, mainly during mitotic cell division. Their specialized structural characteristics enable these motors to perform their essential functions by crosslinking and sliding apart antiparallel microtubules (MTs). In this review, we discuss the specialized structural features of kinesin-5 motors, and the mechanisms by which these features relate to kinesin-5 functions and motile properties. In addition, we discuss the multiple roles of the kinesin-5 motors in dividing as well as in non-dividing cells, and examine their roles in pathogenetic conditions. We describe the recently discovered bidirectional motility in fungi kinesin-5 motors, and discuss its possible physiological relevance. Finally, we also focus on the multiple mechanisms of regulation of these unique motor proteins.https://www.mdpi.com/1422-0067/22/12/6420kinesin-5microtubulesmitosiscell-cycle regulation of kinesin activity
collection DOAJ
language English
format Article
sources DOAJ
author Himanshu Pandey
Mary Popov
Alina Goldstein-Levitin
Larisa Gheber
spellingShingle Himanshu Pandey
Mary Popov
Alina Goldstein-Levitin
Larisa Gheber
Mechanisms by Which Kinesin-5 Motors Perform Their Multiple Intracellular Functions
International Journal of Molecular Sciences
kinesin-5
microtubules
mitosis
cell-cycle regulation of kinesin activity
author_facet Himanshu Pandey
Mary Popov
Alina Goldstein-Levitin
Larisa Gheber
author_sort Himanshu Pandey
title Mechanisms by Which Kinesin-5 Motors Perform Their Multiple Intracellular Functions
title_short Mechanisms by Which Kinesin-5 Motors Perform Their Multiple Intracellular Functions
title_full Mechanisms by Which Kinesin-5 Motors Perform Their Multiple Intracellular Functions
title_fullStr Mechanisms by Which Kinesin-5 Motors Perform Their Multiple Intracellular Functions
title_full_unstemmed Mechanisms by Which Kinesin-5 Motors Perform Their Multiple Intracellular Functions
title_sort mechanisms by which kinesin-5 motors perform their multiple intracellular functions
publisher MDPI AG
series International Journal of Molecular Sciences
issn 1661-6596
1422-0067
publishDate 2021-06-01
description Bipolar kinesin-5 motor proteins perform multiple intracellular functions, mainly during mitotic cell division. Their specialized structural characteristics enable these motors to perform their essential functions by crosslinking and sliding apart antiparallel microtubules (MTs). In this review, we discuss the specialized structural features of kinesin-5 motors, and the mechanisms by which these features relate to kinesin-5 functions and motile properties. In addition, we discuss the multiple roles of the kinesin-5 motors in dividing as well as in non-dividing cells, and examine their roles in pathogenetic conditions. We describe the recently discovered bidirectional motility in fungi kinesin-5 motors, and discuss its possible physiological relevance. Finally, we also focus on the multiple mechanisms of regulation of these unique motor proteins.
topic kinesin-5
microtubules
mitosis
cell-cycle regulation of kinesin activity
url https://www.mdpi.com/1422-0067/22/12/6420
work_keys_str_mv AT himanshupandey mechanismsbywhichkinesin5motorsperformtheirmultipleintracellularfunctions
AT marypopov mechanismsbywhichkinesin5motorsperformtheirmultipleintracellularfunctions
AT alinagoldsteinlevitin mechanismsbywhichkinesin5motorsperformtheirmultipleintracellularfunctions
AT larisagheber mechanismsbywhichkinesin5motorsperformtheirmultipleintracellularfunctions
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