Association between type 2 diabetes and chronic low back pain in general practices in Germany
Introduction There are conflicting results on the association between type 2 diabetes and chronic low back pain (CLBP). Therefore, the goal was to investigate the relationship between type 2 diabetes and CLBP in individuals followed in general practices in Germany.Research design and methods Adults...
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doaj-8c058897a2d94a9baddebe4e3d016ab92021-08-10T10:31:45ZengBMJ Publishing GroupBMJ Open Diabetes Research & Care2052-48972021-08-019110.1136/bmjdrc-2021-002426Association between type 2 diabetes and chronic low back pain in general practices in GermanyAi Koyanagi0Wolfgang Rathmann1Louis Jacob2Karel Kostev3Research and Development Unit, Parc Sanitari Sant Joan de Déu, Barcelona, SpainGerman Diabetes Center, Institute for Biometrics and Epidemiology, Leibniz Institute for Diabetes Research at Heinrich Heine University, Duesseldorf, GermanyResearch and Development Unit, Parc Sanitari Sant Joan de Déu, Barcelona, SpainEpidemiology, IQVIA, Frankfurt, GermanyIntroduction There are conflicting results on the association between type 2 diabetes and chronic low back pain (CLBP). Therefore, the goal was to investigate the relationship between type 2 diabetes and CLBP in individuals followed in general practices in Germany.Research design and methods Adults diagnosed for the first time with type 2 diabetes in 809 general practices in Germany between 2005 and 2018 (index date) were included. Adults without type 2 diabetes were matched (1:1) to those with type 2 diabetes by sex, age, index year, and the annual number of medical consultations (index date: a randomly selected visit date). The association between type 2 diabetes and the 10-year incidence of CLBP was analyzed in conditional Cox regression models adjusted for a wide range of comorbidities, including hypertension, lipid metabolism disorders, and obesity.Results There were 139 002 individuals included in this study (women: 58.0%; mean (SD) age 62.5 (13.4) years). There was a positive association between type 2 diabetes and the incidence of CLBP in the overall sample (HR=1.23, 95% CI: 1.13 to 1.35). Sex-stratified analyses showed a higher risk of CLBP in women (HR=1.68, 95% CI: 1.43 to 1.90) and a lower risk in men with than in their counterparts without type 2 diabetes (HR=0.83, 95% CI: 0.71 to 0.97).Conclusions Newly diagnosed type 2 diabetes was associated with an increased risk of CLBP. There were important sex differences in the type 2 diabetes-CLBP relationship, and more research is warranted to investigate the underlying factors explaining these differences.https://drc.bmj.com/content/9/1/e002426.full |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ai Koyanagi Wolfgang Rathmann Louis Jacob Karel Kostev |
spellingShingle |
Ai Koyanagi Wolfgang Rathmann Louis Jacob Karel Kostev Association between type 2 diabetes and chronic low back pain in general practices in Germany BMJ Open Diabetes Research & Care |
author_facet |
Ai Koyanagi Wolfgang Rathmann Louis Jacob Karel Kostev |
author_sort |
Ai Koyanagi |
title |
Association between type 2 diabetes and chronic low back pain in general practices in Germany |
title_short |
Association between type 2 diabetes and chronic low back pain in general practices in Germany |
title_full |
Association between type 2 diabetes and chronic low back pain in general practices in Germany |
title_fullStr |
Association between type 2 diabetes and chronic low back pain in general practices in Germany |
title_full_unstemmed |
Association between type 2 diabetes and chronic low back pain in general practices in Germany |
title_sort |
association between type 2 diabetes and chronic low back pain in general practices in germany |
publisher |
BMJ Publishing Group |
series |
BMJ Open Diabetes Research & Care |
issn |
2052-4897 |
publishDate |
2021-08-01 |
description |
Introduction There are conflicting results on the association between type 2 diabetes and chronic low back pain (CLBP). Therefore, the goal was to investigate the relationship between type 2 diabetes and CLBP in individuals followed in general practices in Germany.Research design and methods Adults diagnosed for the first time with type 2 diabetes in 809 general practices in Germany between 2005 and 2018 (index date) were included. Adults without type 2 diabetes were matched (1:1) to those with type 2 diabetes by sex, age, index year, and the annual number of medical consultations (index date: a randomly selected visit date). The association between type 2 diabetes and the 10-year incidence of CLBP was analyzed in conditional Cox regression models adjusted for a wide range of comorbidities, including hypertension, lipid metabolism disorders, and obesity.Results There were 139 002 individuals included in this study (women: 58.0%; mean (SD) age 62.5 (13.4) years). There was a positive association between type 2 diabetes and the incidence of CLBP in the overall sample (HR=1.23, 95% CI: 1.13 to 1.35). Sex-stratified analyses showed a higher risk of CLBP in women (HR=1.68, 95% CI: 1.43 to 1.90) and a lower risk in men with than in their counterparts without type 2 diabetes (HR=0.83, 95% CI: 0.71 to 0.97).Conclusions Newly diagnosed type 2 diabetes was associated with an increased risk of CLBP. There were important sex differences in the type 2 diabetes-CLBP relationship, and more research is warranted to investigate the underlying factors explaining these differences. |
url |
https://drc.bmj.com/content/9/1/e002426.full |
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