Leukocyte Trafficking in Cardiovascular Disease: Insights from Experimental Models
Chemokine-induced leukocyte migration into the vessel wall is an early pathological event in the progression of atherosclerosis, the underlying cause of myocardial infarction. The immune-inflammatory response, mediated by both the innate and adaptive immune cells, is involved in the initiation, recr...
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Series: | Mediators of Inflammation |
Online Access: | http://dx.doi.org/10.1155/2017/9746169 |
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doaj-8c115c3863ee45428d9370b8469476842020-11-24T20:45:53ZengHindawi LimitedMediators of Inflammation0962-93511466-18612017-01-01201710.1155/2017/97461699746169Leukocyte Trafficking in Cardiovascular Disease: Insights from Experimental ModelsDaniel P. Jones0Harry D. True1Jyoti Patel2Division of Cardiovascular Medicine, Radcliffe Department of Medicine, British Heart Foundation Centre of Research Excellence, University of Oxford and John Radcliffe Hospital, Oxford OX3 9DU, UKDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, British Heart Foundation Centre of Research Excellence, University of Oxford and John Radcliffe Hospital, Oxford OX3 9DU, UKDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, British Heart Foundation Centre of Research Excellence, University of Oxford and John Radcliffe Hospital, Oxford OX3 9DU, UKChemokine-induced leukocyte migration into the vessel wall is an early pathological event in the progression of atherosclerosis, the underlying cause of myocardial infarction. The immune-inflammatory response, mediated by both the innate and adaptive immune cells, is involved in the initiation, recruitment, and resolution phases of cardiovascular disease progression. Activation of leukocytes via inflammatory mediators such as chemokines, cytokines, and adhesion molecules is instrumental in these processes. In this review, we highlight leukocyte activation with the main focus being on the mechanisms of chemokine-mediated recruitment in atherosclerosis and the response postmyocardial infarction with key examples from experimental models of cardiovascular inflammation.http://dx.doi.org/10.1155/2017/9746169 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Daniel P. Jones Harry D. True Jyoti Patel |
spellingShingle |
Daniel P. Jones Harry D. True Jyoti Patel Leukocyte Trafficking in Cardiovascular Disease: Insights from Experimental Models Mediators of Inflammation |
author_facet |
Daniel P. Jones Harry D. True Jyoti Patel |
author_sort |
Daniel P. Jones |
title |
Leukocyte Trafficking in Cardiovascular Disease: Insights from Experimental Models |
title_short |
Leukocyte Trafficking in Cardiovascular Disease: Insights from Experimental Models |
title_full |
Leukocyte Trafficking in Cardiovascular Disease: Insights from Experimental Models |
title_fullStr |
Leukocyte Trafficking in Cardiovascular Disease: Insights from Experimental Models |
title_full_unstemmed |
Leukocyte Trafficking in Cardiovascular Disease: Insights from Experimental Models |
title_sort |
leukocyte trafficking in cardiovascular disease: insights from experimental models |
publisher |
Hindawi Limited |
series |
Mediators of Inflammation |
issn |
0962-9351 1466-1861 |
publishDate |
2017-01-01 |
description |
Chemokine-induced leukocyte migration into the vessel wall is an early pathological event in the progression of atherosclerosis, the underlying cause of myocardial infarction. The immune-inflammatory response, mediated by both the innate and adaptive immune cells, is involved in the initiation, recruitment, and resolution phases of cardiovascular disease progression. Activation of leukocytes via inflammatory mediators such as chemokines, cytokines, and adhesion molecules is instrumental in these processes. In this review, we highlight leukocyte activation with the main focus being on the mechanisms of chemokine-mediated recruitment in atherosclerosis and the response postmyocardial infarction with key examples from experimental models of cardiovascular inflammation. |
url |
http://dx.doi.org/10.1155/2017/9746169 |
work_keys_str_mv |
AT danielpjones leukocytetraffickingincardiovasculardiseaseinsightsfromexperimentalmodels AT harrydtrue leukocytetraffickingincardiovasculardiseaseinsightsfromexperimentalmodels AT jyotipatel leukocytetraffickingincardiovasculardiseaseinsightsfromexperimentalmodels |
_version_ |
1716813769567371264 |