Prognostic Factors Affecting Survival after Pulmonary Resection of Metastatic Renal Cell Carcinoma: A Multicenter Experience
In this paper we aimed to address the role of pulmonary metastasectomy (PM) in patients affected by Lung Metastases (LM) from Renal Cell Carcinoma (RCC) and to analyse prognostic factors affecting overall survival (OS), disease-free interval (DFI) between primary RCC and first LM, and disease-free s...
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MDPI AG
2021-06-01
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Series: | Cancers |
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Online Access: | https://www.mdpi.com/2072-6694/13/13/3258 |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Elisa Meacci Dania Nachira Edoardo Zanfrini Jessica Evangelista Elizabeth Katherine Anna Triumbari Maria Teresa Congedo Leonardo Petracca Ciavarella Marco Chiappetta Maria Letizia Vita Giovanni Schinzari Ernesto Rossi Giampaolo Tortora Marco Lucchi Marcello Ambrogi Fabrizia Calabrò Francesco Petrella Lorenzo Spaggiari Marco Mammana Andrea Lloret Madrid Federico Rea Diomira Tabacco Stefano Margaritora |
spellingShingle |
Elisa Meacci Dania Nachira Edoardo Zanfrini Jessica Evangelista Elizabeth Katherine Anna Triumbari Maria Teresa Congedo Leonardo Petracca Ciavarella Marco Chiappetta Maria Letizia Vita Giovanni Schinzari Ernesto Rossi Giampaolo Tortora Marco Lucchi Marcello Ambrogi Fabrizia Calabrò Francesco Petrella Lorenzo Spaggiari Marco Mammana Andrea Lloret Madrid Federico Rea Diomira Tabacco Stefano Margaritora Prognostic Factors Affecting Survival after Pulmonary Resection of Metastatic Renal Cell Carcinoma: A Multicenter Experience Cancers renal cell carcinoma lung metastases metastasectomy metastatic renal cell carcinoma |
author_facet |
Elisa Meacci Dania Nachira Edoardo Zanfrini Jessica Evangelista Elizabeth Katherine Anna Triumbari Maria Teresa Congedo Leonardo Petracca Ciavarella Marco Chiappetta Maria Letizia Vita Giovanni Schinzari Ernesto Rossi Giampaolo Tortora Marco Lucchi Marcello Ambrogi Fabrizia Calabrò Francesco Petrella Lorenzo Spaggiari Marco Mammana Andrea Lloret Madrid Federico Rea Diomira Tabacco Stefano Margaritora |
author_sort |
Elisa Meacci |
title |
Prognostic Factors Affecting Survival after Pulmonary Resection of Metastatic Renal Cell Carcinoma: A Multicenter Experience |
title_short |
Prognostic Factors Affecting Survival after Pulmonary Resection of Metastatic Renal Cell Carcinoma: A Multicenter Experience |
title_full |
Prognostic Factors Affecting Survival after Pulmonary Resection of Metastatic Renal Cell Carcinoma: A Multicenter Experience |
title_fullStr |
Prognostic Factors Affecting Survival after Pulmonary Resection of Metastatic Renal Cell Carcinoma: A Multicenter Experience |
title_full_unstemmed |
Prognostic Factors Affecting Survival after Pulmonary Resection of Metastatic Renal Cell Carcinoma: A Multicenter Experience |
title_sort |
prognostic factors affecting survival after pulmonary resection of metastatic renal cell carcinoma: a multicenter experience |
publisher |
MDPI AG |
series |
Cancers |
issn |
2072-6694 |
publishDate |
2021-06-01 |
description |
In this paper we aimed to address the role of pulmonary metastasectomy (PM) in patients affected by Lung Metastases (LM) from Renal Cell Carcinoma (RCC) and to analyse prognostic factors affecting overall survival (OS), disease-free interval (DFI) between primary RCC and first LM, and disease-free survival (DFS) after PM and before lung recurrence. Medical records of 210 patients who underwent PM from RCC in 4 Italian Thoracic Centres, from January 2000 to September 2019, were collected and analysed. All patients underwent RCC resection before lung surgery. The main RCC histology was clear cells (188, 89.5%). The 5- and 10-year OS from the first lung operation were 60% and 34%, respectively. LM synchronous with RCC (<i>p</i> = 0.01) and (Karnofsky Performance Status Scale) KPSS < 80% (<i>p</i> < 0.001) negatively influenced OS. Five- and 10-year DFI were 54% and 28%, respectively. The main factors negatively influencing DFI were: male gender (<i>p</i> = 0.039), KPSS < 80% (<i>p</i> = 0.009) and lactate dehydrogenase > 1.5 times 140 U/L (<i>p</i> = 0.001). Five- and 10-year disease-free survival were 54% and 28%, respectively; multiple LM (<i>p</i> = 0.036), KPSS < 80% (<i>p</i> = 0.001) and histology of RCC other than clear cells negatively influenced disease-free survival. Conclusions: patients with KPSS > 80%, single metachronous LM with a long DFI from RCC diagnosis, and clear cell histology, benefit from pulmonary metastasectomy. |
topic |
renal cell carcinoma lung metastases metastasectomy metastatic renal cell carcinoma |
url |
https://www.mdpi.com/2072-6694/13/13/3258 |
work_keys_str_mv |
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doaj-8c1f63daec9e413b8fbabaa7e7a5ec5e2021-07-15T15:31:45ZengMDPI AGCancers2072-66942021-06-01133258325810.3390/cancers13133258Prognostic Factors Affecting Survival after Pulmonary Resection of Metastatic Renal Cell Carcinoma: A Multicenter ExperienceElisa Meacci0Dania Nachira1Edoardo Zanfrini2Jessica Evangelista3Elizabeth Katherine Anna Triumbari4Maria Teresa Congedo5Leonardo Petracca Ciavarella6Marco Chiappetta7Maria Letizia Vita8Giovanni Schinzari9Ernesto Rossi10Giampaolo Tortora11Marco Lucchi12Marcello Ambrogi13Fabrizia Calabrò14Francesco Petrella15Lorenzo Spaggiari16Marco Mammana17Andrea Lloret Madrid18Federico Rea19Diomira Tabacco20Stefano Margaritora21Department of General Thoracic Surgery, Fondazione Policlinico Universitario “A. Gemelli”, IRCCS, Università Cattolica del Sacro Cuore, 00167 Rome, ItalyDepartment of General Thoracic Surgery, Fondazione Policlinico Universitario “A. Gemelli”, IRCCS, Università Cattolica del Sacro Cuore, 00167 Rome, ItalyDepartment of General Thoracic Surgery, Fondazione Policlinico Universitario “A. Gemelli”, IRCCS, Università Cattolica del Sacro Cuore, 00167 Rome, ItalyDepartment of General Thoracic Surgery, Fondazione Policlinico Universitario “A. Gemelli”, IRCCS, Università Cattolica del Sacro Cuore, 00167 Rome, ItalySection of Nuclear Medicine, Department of Radiological Sciences and Haematology, Università Cattolica del Sacro Cuore, 00167 Rome, ItalyDepartment of General Thoracic Surgery, Fondazione Policlinico Universitario “A. Gemelli”, IRCCS, Università Cattolica del Sacro Cuore, 00167 Rome, ItalyDepartment of General Thoracic Surgery, Fondazione Policlinico Universitario “A. Gemelli”, IRCCS, Università Cattolica del Sacro Cuore, 00167 Rome, ItalyDepartment of General Thoracic Surgery, Fondazione Policlinico Universitario “A. Gemelli”, IRCCS, Università Cattolica del Sacro Cuore, 00167 Rome, ItalyDepartment of General Thoracic Surgery, Fondazione Policlinico Universitario “A. Gemelli”, IRCCS, Università Cattolica del Sacro Cuore, 00167 Rome, ItalyDepartment of Medical Oncology, Fondazione Policlinico Universitario “A. Gemelli”, IRCCS, Università Cattolica del Sacro Cuore, 00167 Rome, ItalyDepartment of Medical Oncology, Fondazione Policlinico Universitario “A. Gemelli”, IRCCS, Università Cattolica del Sacro Cuore, 00167 Rome, ItalyDepartment of Medical Oncology, Fondazione Policlinico Universitario “A. Gemelli”, IRCCS, Università Cattolica del Sacro Cuore, 00167 Rome, ItalyDepartment of General Thoracic Surgery, Azienda Ospedaliero Universitaria Pisana, 56124 Pisa, ItalyDepartment of General Thoracic Surgery, Azienda Ospedaliero Universitaria Pisana, 56124 Pisa, ItalyDepartment of General Thoracic Surgery, Azienda Ospedaliero Universitaria Pisana, 56124 Pisa, ItalyDepartment of Thoracic Surgery, IEO European Institute of Oncology IRCCS, 20141 Milan, ItalyDepartment of Thoracic Surgery, IEO European Institute of Oncology IRCCS, 20141 Milan, ItalyThoracic Surgery Division, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, Padova University Hospital, 35122 Padova, ItalyThoracic Surgery Division, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, Padova University Hospital, 35122 Padova, ItalyThoracic Surgery Division, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, Padova University Hospital, 35122 Padova, ItalyDepartment of General Thoracic Surgery, Fondazione Policlinico Universitario “A. Gemelli”, IRCCS, Università Cattolica del Sacro Cuore, 00167 Rome, ItalyDepartment of General Thoracic Surgery, Fondazione Policlinico Universitario “A. Gemelli”, IRCCS, Università Cattolica del Sacro Cuore, 00167 Rome, ItalyIn this paper we aimed to address the role of pulmonary metastasectomy (PM) in patients affected by Lung Metastases (LM) from Renal Cell Carcinoma (RCC) and to analyse prognostic factors affecting overall survival (OS), disease-free interval (DFI) between primary RCC and first LM, and disease-free survival (DFS) after PM and before lung recurrence. Medical records of 210 patients who underwent PM from RCC in 4 Italian Thoracic Centres, from January 2000 to September 2019, were collected and analysed. All patients underwent RCC resection before lung surgery. The main RCC histology was clear cells (188, 89.5%). The 5- and 10-year OS from the first lung operation were 60% and 34%, respectively. LM synchronous with RCC (<i>p</i> = 0.01) and (Karnofsky Performance Status Scale) KPSS < 80% (<i>p</i> < 0.001) negatively influenced OS. Five- and 10-year DFI were 54% and 28%, respectively. The main factors negatively influencing DFI were: male gender (<i>p</i> = 0.039), KPSS < 80% (<i>p</i> = 0.009) and lactate dehydrogenase > 1.5 times 140 U/L (<i>p</i> = 0.001). Five- and 10-year disease-free survival were 54% and 28%, respectively; multiple LM (<i>p</i> = 0.036), KPSS < 80% (<i>p</i> = 0.001) and histology of RCC other than clear cells negatively influenced disease-free survival. Conclusions: patients with KPSS > 80%, single metachronous LM with a long DFI from RCC diagnosis, and clear cell histology, benefit from pulmonary metastasectomy.https://www.mdpi.com/2072-6694/13/13/3258renal cell carcinomalung metastasesmetastasectomymetastatic renal cell carcinoma |