Physiologically Based Pharmacokinetic Modelling with Dynamic PET Data to Study the In Vivo Effects of Transporter Inhibition on Hepatobiliary Clearance in Mice
Physiologically based pharmacokinetic modelling (PBPK) is a powerful tool to predict in vivo pharmacokinetics based on physiological parameters and data from in vivo studies and in vitro assays. In vivo PBPK modelling in laboratory animals by noninvasive imaging could help to improve the in vivo-in...
Main Authors: | Marco F. Taddio, Linjing Mu, Claudia Keller, Roger Schibli, Stefanie D. Krämer |
---|---|
Format: | Article |
Language: | English |
Published: |
Hindawi-Wiley
2018-01-01
|
Series: | Contrast Media & Molecular Imaging |
Online Access: | http://dx.doi.org/10.1155/2018/5849047 |
Similar Items
-
The Hepatobiliary Transport of Rosuvastatin In Vivo
by: Bergman, Ebba
Published: (2009) -
Tauvid™: The First FDA-Approved PET Tracer for Imaging Tau Pathology in Alzheimer’s Disease
by: Caitlin V. M. L. Jie, et al.
Published: (2021-01-01) -
The extended clearance model and its use for the interpretation of hepatobiliary elimination data
by: Gian Camenisch, et al.
Published: (2015-03-01) -
Synthesis and Preliminary Evaluation of a 2-Oxoquinoline Carboxylic Acid Derivative for PET Imaging the Cannabinoid Type 2 Receptor
by: Linjing Mu, et al.
Published: (2014-03-01) -
In vivo Pharmacokinetics of Two New Thrombin Inhibitor Prodrugs : Emphasis on Intestinal and Hepatobiliary Disposition and the Influence of Interacting Drugs
by: Matsson, Elin
Published: (2010)