Preleukemic and second-hit mutational events in an acute myeloid leukemia patient with a novel germline RUNX1 mutation

Preleukemic and second-hit mutational events in an acute myeloid leukemia patient with a novel germline RUNX1 mutation

Abstract Background Germline mutations in the RUNX1 transcription factor give rise to a rare autosomal dominant genetic condition classified under the entity: Familial Platelet Disorders with predisposition to Acute Myeloid Leukaemia (FPD/AML). While several studies have identified a myriad of germl...

Full description

Bibliographic Details
Main Authors: Isaac KS Ng, Joanne Lee, Christopher Ng, Bustamin Kosmo, Lily Chiu, Elaine Seah, Michelle Meng Huang Mok, Karen Tan, Motomi Osato, Wee-Joo Chng, Benedict Yan, Lip Kun Tan
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Biomarker Research
Subjects:
Familial platelet disorder
Acute myeloid Leukaemia
RUNX1
Stem cell transplant
Online Access:http://link.springer.com/article/10.1186/s40364-018-0130-2

Similar Items

Similar Items