Ethical issues in global neuroimaging genetics collaborations
Neuroimaging genetics is a rapidly developing field that combines neuropsychiatric genetics studies with imaging modalities to investigate how genetic variation influences brain structure and function. As both genetic and imaging technologies improve further, their combined power may hold translatio...
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doaj-8c2729c6d28f4652b611ae45d67393b92020-12-13T04:18:06ZengElsevierNeuroImage1095-95722020-11-01221117208Ethical issues in global neuroimaging genetics collaborationsAndrea Palk0Judy Illes1Paul M Thompson2Dan J Stein3Department of Philosophy, Stellenbosch University, Bag X1, Matieland, Stellenbosch, 7602, South Africa; Corresponding author.Neuroethics Canada, Division of Neurology, Department of Medicine, University of British Columbia, Vancouver, BC, CanadaImaging Genetics Center, Mark & Mary Stevens Institute for Neuroimaging & Informatics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USASA MRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry & Neuroscience Institute, University of Cape Town, Groote Schuur Hospital, Cape Town 7925, South AfricaNeuroimaging genetics is a rapidly developing field that combines neuropsychiatric genetics studies with imaging modalities to investigate how genetic variation influences brain structure and function. As both genetic and imaging technologies improve further, their combined power may hold translational potential in terms of improving psychiatric nosology, diagnosis, and treatment. While neuroimaging genetics studies offer a number of scientific advantages, they also face challenges. In response to some of these challenges, global neuroimaging genetics collaborations have been created to pool and compare brain data and replicate study findings. Attention has been paid to ethical issues in genetics, neuroimaging, and multi-site collaborative research, respectively, but there have been few substantive discussions of the ethical issues generated by the confluence of these areas in global neuroimaging genetics collaborations. Our discussion focuses on two areas: benefits and risks of global neuroimaging genetics collaborations and the potential impact of neuroimaging genetics research findings in low- and middle-income countries. Global neuroimaging genetics collaborations have the potential to enhance relations between countries and address global mental health challenges, however there are risks regarding inequity, exploitation and data sharing. Moreover, neuroimaging genetics research in low- and middle-income countries must address the issue of feedback of findings and the risk of essentializing and stigmatizing interpretations of mental disorders. We conclude by examining how the notion of solidarity, informed by an African Ethics framework, may justify some of the suggestions made in our discussion.http://www.sciencedirect.com/science/article/pii/S1053811920306947BioethicsNeuroethicsGenethicsNeuroimaging geneticsGlobal research collaborations |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Andrea Palk Judy Illes Paul M Thompson Dan J Stein |
spellingShingle |
Andrea Palk Judy Illes Paul M Thompson Dan J Stein Ethical issues in global neuroimaging genetics collaborations NeuroImage Bioethics Neuroethics Genethics Neuroimaging genetics Global research collaborations |
author_facet |
Andrea Palk Judy Illes Paul M Thompson Dan J Stein |
author_sort |
Andrea Palk |
title |
Ethical issues in global neuroimaging genetics collaborations |
title_short |
Ethical issues in global neuroimaging genetics collaborations |
title_full |
Ethical issues in global neuroimaging genetics collaborations |
title_fullStr |
Ethical issues in global neuroimaging genetics collaborations |
title_full_unstemmed |
Ethical issues in global neuroimaging genetics collaborations |
title_sort |
ethical issues in global neuroimaging genetics collaborations |
publisher |
Elsevier |
series |
NeuroImage |
issn |
1095-9572 |
publishDate |
2020-11-01 |
description |
Neuroimaging genetics is a rapidly developing field that combines neuropsychiatric genetics studies with imaging modalities to investigate how genetic variation influences brain structure and function. As both genetic and imaging technologies improve further, their combined power may hold translational potential in terms of improving psychiatric nosology, diagnosis, and treatment. While neuroimaging genetics studies offer a number of scientific advantages, they also face challenges. In response to some of these challenges, global neuroimaging genetics collaborations have been created to pool and compare brain data and replicate study findings. Attention has been paid to ethical issues in genetics, neuroimaging, and multi-site collaborative research, respectively, but there have been few substantive discussions of the ethical issues generated by the confluence of these areas in global neuroimaging genetics collaborations. Our discussion focuses on two areas: benefits and risks of global neuroimaging genetics collaborations and the potential impact of neuroimaging genetics research findings in low- and middle-income countries. Global neuroimaging genetics collaborations have the potential to enhance relations between countries and address global mental health challenges, however there are risks regarding inequity, exploitation and data sharing. Moreover, neuroimaging genetics research in low- and middle-income countries must address the issue of feedback of findings and the risk of essentializing and stigmatizing interpretations of mental disorders. We conclude by examining how the notion of solidarity, informed by an African Ethics framework, may justify some of the suggestions made in our discussion. |
topic |
Bioethics Neuroethics Genethics Neuroimaging genetics Global research collaborations |
url |
http://www.sciencedirect.com/science/article/pii/S1053811920306947 |
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