Transposon Reactivation in the Germline May Be Useful for Both Transposons and Their Host Genomes

Transposable elements (TEs) are long-term residents of eukaryotic genomes that make up a large portion of these genomes. They can be considered as perfectly fine members of genomes replicating with resident genes and being transmitted vertically to the next generation. However, unlike regular genes,...

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Main Authors:	Stéphanie Maupetit-Mehouas, Chantal Vaury
Format:	Article
Language:	English
Published:	MDPI AG 2020-05-01
Series:	Cells
Subjects:	retroelements transposable elements piRNAs DNA methylation KRAB complex silencing
Online Access:	https://www.mdpi.com/2073-4409/9/5/1172

id	doaj-8c3d0ab8e99248528e39e748d20aee59
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spelling	doaj-8c3d0ab8e99248528e39e748d20aee592020-11-25T02:00:30ZengMDPI AGCells2073-44092020-05-0191172117210.3390/cells9051172Transposon Reactivation in the Germline May Be Useful for Both Transposons and Their Host GenomesStéphanie Maupetit-Mehouas0Chantal Vaury1Inserm, Faculté de Médecine, CRBC, GReD Institute, Université Clermont Auvergne, CNRS, 28 place Henri Dunant, TSA 50400, CEDEX 1, 63001 Clermont-Ferrand, FranceInserm, Faculté de Médecine, CRBC, GReD Institute, Université Clermont Auvergne, CNRS, 28 place Henri Dunant, TSA 50400, CEDEX 1, 63001 Clermont-Ferrand, FranceTransposable elements (TEs) are long-term residents of eukaryotic genomes that make up a large portion of these genomes. They can be considered as perfectly fine members of genomes replicating with resident genes and being transmitted vertically to the next generation. However, unlike regular genes, TEs have the ability to send new copies to new sites. As such, they have been considered as parasitic members ensuring their own replication. In another view, TEs may also be considered as symbiotic sequences providing shared benefits after mutualistic interactions with their host genome. In this review, we recall the relationship between TEs and their host genome and discuss why transient relaxation of TE silencing within specific developmental windows may be useful for both.https://www.mdpi.com/2073-4409/9/5/1172retroelementstransposable elementspiRNAsDNA methylationKRAB complexsilencing
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Stéphanie Maupetit-Mehouas Chantal Vaury
spellingShingle	Stéphanie Maupetit-Mehouas Chantal Vaury Transposon Reactivation in the Germline May Be Useful for Both Transposons and Their Host Genomes Cells retroelements transposable elements piRNAs DNA methylation KRAB complex silencing
author_facet	Stéphanie Maupetit-Mehouas Chantal Vaury
author_sort	Stéphanie Maupetit-Mehouas
title	Transposon Reactivation in the Germline May Be Useful for Both Transposons and Their Host Genomes
title_short	Transposon Reactivation in the Germline May Be Useful for Both Transposons and Their Host Genomes
title_full	Transposon Reactivation in the Germline May Be Useful for Both Transposons and Their Host Genomes
title_fullStr	Transposon Reactivation in the Germline May Be Useful for Both Transposons and Their Host Genomes
title_full_unstemmed	Transposon Reactivation in the Germline May Be Useful for Both Transposons and Their Host Genomes
title_sort	transposon reactivation in the germline may be useful for both transposons and their host genomes
publisher	MDPI AG
series	Cells
issn	2073-4409
publishDate	2020-05-01
description	Transposable elements (TEs) are long-term residents of eukaryotic genomes that make up a large portion of these genomes. They can be considered as perfectly fine members of genomes replicating with resident genes and being transmitted vertically to the next generation. However, unlike regular genes, TEs have the ability to send new copies to new sites. As such, they have been considered as parasitic members ensuring their own replication. In another view, TEs may also be considered as symbiotic sequences providing shared benefits after mutualistic interactions with their host genome. In this review, we recall the relationship between TEs and their host genome and discuss why transient relaxation of TE silencing within specific developmental windows may be useful for both.
topic	retroelements transposable elements piRNAs DNA methylation KRAB complex silencing
url	https://www.mdpi.com/2073-4409/9/5/1172
work_keys_str_mv	AT stephaniemaupetitmehouas transposonreactivationinthegermlinemaybeusefulforbothtransposonsandtheirhostgenomes AT chantalvaury transposonreactivationinthegermlinemaybeusefulforbothtransposonsandtheirhostgenomes
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Transposon Reactivation in the Germline May Be Useful for Both Transposons and Their Host Genomes

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