Transposon Reactivation in the Germline May Be Useful for Both Transposons and Their Host Genomes
Transposable elements (TEs) are long-term residents of eukaryotic genomes that make up a large portion of these genomes. They can be considered as perfectly fine members of genomes replicating with resident genes and being transmitted vertically to the next generation. However, unlike regular genes,...
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2020-05-01
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Online Access: | https://www.mdpi.com/2073-4409/9/5/1172 |
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doaj-8c3d0ab8e99248528e39e748d20aee592020-11-25T02:00:30ZengMDPI AGCells2073-44092020-05-0191172117210.3390/cells9051172Transposon Reactivation in the Germline May Be Useful for Both Transposons and Their Host GenomesStéphanie Maupetit-Mehouas0Chantal Vaury1Inserm, Faculté de Médecine, CRBC, GReD Institute, Université Clermont Auvergne, CNRS, 28 place Henri Dunant, TSA 50400, CEDEX 1, 63001 Clermont-Ferrand, FranceInserm, Faculté de Médecine, CRBC, GReD Institute, Université Clermont Auvergne, CNRS, 28 place Henri Dunant, TSA 50400, CEDEX 1, 63001 Clermont-Ferrand, FranceTransposable elements (TEs) are long-term residents of eukaryotic genomes that make up a large portion of these genomes. They can be considered as perfectly fine members of genomes replicating with resident genes and being transmitted vertically to the next generation. However, unlike regular genes, TEs have the ability to send new copies to new sites. As such, they have been considered as parasitic members ensuring their own replication. In another view, TEs may also be considered as symbiotic sequences providing shared benefits after mutualistic interactions with their host genome. In this review, we recall the relationship between TEs and their host genome and discuss why transient relaxation of TE silencing within specific developmental windows may be useful for both.https://www.mdpi.com/2073-4409/9/5/1172retroelementstransposable elementspiRNAsDNA methylationKRAB complexsilencing |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Stéphanie Maupetit-Mehouas Chantal Vaury |
spellingShingle |
Stéphanie Maupetit-Mehouas Chantal Vaury Transposon Reactivation in the Germline May Be Useful for Both Transposons and Their Host Genomes Cells retroelements transposable elements piRNAs DNA methylation KRAB complex silencing |
author_facet |
Stéphanie Maupetit-Mehouas Chantal Vaury |
author_sort |
Stéphanie Maupetit-Mehouas |
title |
Transposon Reactivation in the Germline May Be Useful for Both Transposons and Their Host Genomes |
title_short |
Transposon Reactivation in the Germline May Be Useful for Both Transposons and Their Host Genomes |
title_full |
Transposon Reactivation in the Germline May Be Useful for Both Transposons and Their Host Genomes |
title_fullStr |
Transposon Reactivation in the Germline May Be Useful for Both Transposons and Their Host Genomes |
title_full_unstemmed |
Transposon Reactivation in the Germline May Be Useful for Both Transposons and Their Host Genomes |
title_sort |
transposon reactivation in the germline may be useful for both transposons and their host genomes |
publisher |
MDPI AG |
series |
Cells |
issn |
2073-4409 |
publishDate |
2020-05-01 |
description |
Transposable elements (TEs) are long-term residents of eukaryotic genomes that make up a large portion of these genomes. They can be considered as perfectly fine members of genomes replicating with resident genes and being transmitted vertically to the next generation. However, unlike regular genes, TEs have the ability to send new copies to new sites. As such, they have been considered as parasitic members ensuring their own replication. In another view, TEs may also be considered as symbiotic sequences providing shared benefits after mutualistic interactions with their host genome. In this review, we recall the relationship between TEs and their host genome and discuss why transient relaxation of TE silencing within specific developmental windows may be useful for both. |
topic |
retroelements transposable elements piRNAs DNA methylation KRAB complex silencing |
url |
https://www.mdpi.com/2073-4409/9/5/1172 |
work_keys_str_mv |
AT stephaniemaupetitmehouas transposonreactivationinthegermlinemaybeusefulforbothtransposonsandtheirhostgenomes AT chantalvaury transposonreactivationinthegermlinemaybeusefulforbothtransposonsandtheirhostgenomes |
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1724960130995322880 |