A survey on the appropriateness of drug therapy in patients with renal dysfunction at the Internal Medicine Ward FMUI/Dr. Cipto Mangunkusumo Hospital

Aim Dose adjusment and drug selection is important in patient with renal dysfuction.This study was aimed to assess the accuracy of dose adjustment and drug selection for renal dysfunction patient at the Internal Medicine Ward FMUI/Dr. Cipto Mangunkusumo Hospital, Jakarta. Methods Patients ≥ 18 yea...

Full description

Bibliographic Details
Main Authors: Vivian Soetikno, Imam Effendi, Nafrialdi Nafrialdi, Rianto Setiabudy
Format: Article
Language:English
Published: Faculty of Medicine Universitas Indonesia 2009-05-01
Series:Medical Journal of Indonesia
Online Access:http://mji.ui.ac.id/journal/index.php/mji/article/view/348
id doaj-8c4e5ae6417a47f780c90f3feaa74b65
record_format Article
spelling doaj-8c4e5ae6417a47f780c90f3feaa74b652020-11-25T02:21:59ZengFaculty of Medicine Universitas Indonesia Medical Journal of Indonesia0853-17732252-80832009-05-0118210.13181/mji.v18i2.348345A survey on the appropriateness of drug therapy in patients with renal dysfunction at the Internal Medicine Ward FMUI/Dr. Cipto Mangunkusumo HospitalVivian SoetiknoImam EffendiNafrialdi NafrialdiRianto Setiabudy Aim Dose adjusment and drug selection is important in patient with renal dysfuction.This study was aimed to assess the accuracy of dose adjustment and drug selection for renal dysfunction patient at the Internal Medicine Ward FMUI/Dr. Cipto Mangunkusumo Hospital, Jakarta. Methods Patients ≥ 18 years old with estimated creatinine clearance < 60 mL/minute based on Cockroft-Gault formula were included in this study. The drugs assessed were those excreted by the kidney or having nephrotoxic effect. The appropriateness of drug selection is assessed based on the preserce or not contraindication or potential of drug-drug interaction. The accuracy of dose adjustment were assessed based on information available in various textbooks, literatures, and drug brochures. Data were collected between May to July 2007. Results Data obtained from 43 patients met the inclusion criterias demonstrated that 164 out of 385 drug prescriptions were mainly eliminated by the kidney or have nephrotoxic characteristic. Out of 164 drug prescriptions, 142 (86.5%) were appropriately adjusted, while the other 22 (13.5%) were inappropriately adjusted for the dose. There was only one contraindication for the usage of the drug and 15.1% potentially drug interaction. Conclusion Dose adjustment and drug selections in patients with renal dysfunction at the Internal Medicine Ward FMUI/Dr. Cipto Mangunkusumo Hospital are conducted appropriately. (Med J Indones 2009; 18: 108-13) Key words: renal dysfunction, drug interaction, contraindication, dose adjusment http://mji.ui.ac.id/journal/index.php/mji/article/view/348
collection DOAJ
language English
format Article
sources DOAJ
author Vivian Soetikno
Imam Effendi
Nafrialdi Nafrialdi
Rianto Setiabudy
spellingShingle Vivian Soetikno
Imam Effendi
Nafrialdi Nafrialdi
Rianto Setiabudy
A survey on the appropriateness of drug therapy in patients with renal dysfunction at the Internal Medicine Ward FMUI/Dr. Cipto Mangunkusumo Hospital
Medical Journal of Indonesia
author_facet Vivian Soetikno
Imam Effendi
Nafrialdi Nafrialdi
Rianto Setiabudy
author_sort Vivian Soetikno
title A survey on the appropriateness of drug therapy in patients with renal dysfunction at the Internal Medicine Ward FMUI/Dr. Cipto Mangunkusumo Hospital
title_short A survey on the appropriateness of drug therapy in patients with renal dysfunction at the Internal Medicine Ward FMUI/Dr. Cipto Mangunkusumo Hospital
title_full A survey on the appropriateness of drug therapy in patients with renal dysfunction at the Internal Medicine Ward FMUI/Dr. Cipto Mangunkusumo Hospital
title_fullStr A survey on the appropriateness of drug therapy in patients with renal dysfunction at the Internal Medicine Ward FMUI/Dr. Cipto Mangunkusumo Hospital
title_full_unstemmed A survey on the appropriateness of drug therapy in patients with renal dysfunction at the Internal Medicine Ward FMUI/Dr. Cipto Mangunkusumo Hospital
title_sort survey on the appropriateness of drug therapy in patients with renal dysfunction at the internal medicine ward fmui/dr. cipto mangunkusumo hospital
publisher Faculty of Medicine Universitas Indonesia
series Medical Journal of Indonesia
issn 0853-1773
2252-8083
publishDate 2009-05-01
description Aim Dose adjusment and drug selection is important in patient with renal dysfuction.This study was aimed to assess the accuracy of dose adjustment and drug selection for renal dysfunction patient at the Internal Medicine Ward FMUI/Dr. Cipto Mangunkusumo Hospital, Jakarta. Methods Patients ≥ 18 years old with estimated creatinine clearance < 60 mL/minute based on Cockroft-Gault formula were included in this study. The drugs assessed were those excreted by the kidney or having nephrotoxic effect. The appropriateness of drug selection is assessed based on the preserce or not contraindication or potential of drug-drug interaction. The accuracy of dose adjustment were assessed based on information available in various textbooks, literatures, and drug brochures. Data were collected between May to July 2007. Results Data obtained from 43 patients met the inclusion criterias demonstrated that 164 out of 385 drug prescriptions were mainly eliminated by the kidney or have nephrotoxic characteristic. Out of 164 drug prescriptions, 142 (86.5%) were appropriately adjusted, while the other 22 (13.5%) were inappropriately adjusted for the dose. There was only one contraindication for the usage of the drug and 15.1% potentially drug interaction. Conclusion Dose adjustment and drug selections in patients with renal dysfunction at the Internal Medicine Ward FMUI/Dr. Cipto Mangunkusumo Hospital are conducted appropriately. (Med J Indones 2009; 18: 108-13) Key words: renal dysfunction, drug interaction, contraindication, dose adjusment
url http://mji.ui.ac.id/journal/index.php/mji/article/view/348
work_keys_str_mv AT viviansoetikno asurveyontheappropriatenessofdrugtherapyinpatientswithrenaldysfunctionattheinternalmedicinewardfmuidrciptomangunkusumohospital
AT imameffendi asurveyontheappropriatenessofdrugtherapyinpatientswithrenaldysfunctionattheinternalmedicinewardfmuidrciptomangunkusumohospital
AT nafrialdinafrialdi asurveyontheappropriatenessofdrugtherapyinpatientswithrenaldysfunctionattheinternalmedicinewardfmuidrciptomangunkusumohospital
AT riantosetiabudy asurveyontheappropriatenessofdrugtherapyinpatientswithrenaldysfunctionattheinternalmedicinewardfmuidrciptomangunkusumohospital
AT viviansoetikno surveyontheappropriatenessofdrugtherapyinpatientswithrenaldysfunctionattheinternalmedicinewardfmuidrciptomangunkusumohospital
AT imameffendi surveyontheappropriatenessofdrugtherapyinpatientswithrenaldysfunctionattheinternalmedicinewardfmuidrciptomangunkusumohospital
AT nafrialdinafrialdi surveyontheappropriatenessofdrugtherapyinpatientswithrenaldysfunctionattheinternalmedicinewardfmuidrciptomangunkusumohospital
AT riantosetiabudy surveyontheappropriatenessofdrugtherapyinpatientswithrenaldysfunctionattheinternalmedicinewardfmuidrciptomangunkusumohospital
_version_ 1724864153941704704