RISK ASSESSMENT AND MONITORING OF HEPATOTOXIC REACTIONS IN TUBERCULOSIS PATIENTS
In order to detect risk groups for drug-induced liver lesions and to develop the procedure for differential monitoring of liver tests during tuberculosis chemotherapy, a prospective study was performed including 435 new tuberculosis patients. The one-dimensional and regression analysis helped to ide...
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NEW TERRA Publishing House
2017-10-01
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doaj-8c534d4874b948ce88731dd7810313342021-07-28T20:57:45ZrusNEW TERRA Publishing HouseTuberkulez i Bolezni Lëgkih2075-12302542-15062017-10-01959404810.21292/2075-1230-2017-95-9-40-481044RISK ASSESSMENT AND MONITORING OF HEPATOTOXIC REACTIONS IN TUBERCULOSIS PATIENTSD. A. IVАNOVА0S. E. BORISOV1Moscow Municipal Scientific Practical Center of Tuberculosis ControlMoscow Municipal Scientific Practical Center of Tuberculosis ControlIn order to detect risk groups for drug-induced liver lesions and to develop the procedure for differential monitoring of liver tests during tuberculosis chemotherapy, a prospective study was performed including 435 new tuberculosis patients. The one-dimensional and regression analysis helped to identify risk factors of drug-induced liver lesions (female sex, poor nutrition, absentation from smoking, history of medicamentous allergy), and based on them scores for risk assessment before the start of chemotherapy were worked out and validated. Drug-induced liver lesions developed in 110 patients (25.3%, 95% CI 21.4-29.6), of them 45 (40.9%) developed liver lesion during first 14 days after the start of chemotherapy. The group facing a higher risk of drug-induced liver lesions developed them after a longer period of time; the number of early liver lesions made 18.5% in the high-risk group, and 6.6% (p = 0.02) in the low-risk group. The procedure of laboratory monitoring depending on the degree of risk was offered for early diagnostics of drug-induced liver lesions.https://www.tibl-journal.com/jour/article/view/1044tuberculosis treatmentdrug-induced liver lesionsrisk factorsmonitoring |
collection |
DOAJ |
language |
Russian |
format |
Article |
sources |
DOAJ |
author |
D. A. IVАNOVА S. E. BORISOV |
spellingShingle |
D. A. IVАNOVА S. E. BORISOV RISK ASSESSMENT AND MONITORING OF HEPATOTOXIC REACTIONS IN TUBERCULOSIS PATIENTS Tuberkulez i Bolezni Lëgkih tuberculosis treatment drug-induced liver lesions risk factors monitoring |
author_facet |
D. A. IVАNOVА S. E. BORISOV |
author_sort |
D. A. IVАNOVА |
title |
RISK ASSESSMENT AND MONITORING OF HEPATOTOXIC REACTIONS IN TUBERCULOSIS PATIENTS |
title_short |
RISK ASSESSMENT AND MONITORING OF HEPATOTOXIC REACTIONS IN TUBERCULOSIS PATIENTS |
title_full |
RISK ASSESSMENT AND MONITORING OF HEPATOTOXIC REACTIONS IN TUBERCULOSIS PATIENTS |
title_fullStr |
RISK ASSESSMENT AND MONITORING OF HEPATOTOXIC REACTIONS IN TUBERCULOSIS PATIENTS |
title_full_unstemmed |
RISK ASSESSMENT AND MONITORING OF HEPATOTOXIC REACTIONS IN TUBERCULOSIS PATIENTS |
title_sort |
risk assessment and monitoring of hepatotoxic reactions in tuberculosis patients |
publisher |
NEW TERRA Publishing House |
series |
Tuberkulez i Bolezni Lëgkih |
issn |
2075-1230 2542-1506 |
publishDate |
2017-10-01 |
description |
In order to detect risk groups for drug-induced liver lesions and to develop the procedure for differential monitoring of liver tests during tuberculosis chemotherapy, a prospective study was performed including 435 new tuberculosis patients. The one-dimensional and regression analysis helped to identify risk factors of drug-induced liver lesions (female sex, poor nutrition, absentation from smoking, history of medicamentous allergy), and based on them scores for risk assessment before the start of chemotherapy were worked out and validated. Drug-induced liver lesions developed in 110 patients (25.3%, 95% CI 21.4-29.6), of them 45 (40.9%) developed liver lesion during first 14 days after the start of chemotherapy. The group facing a higher risk of drug-induced liver lesions developed them after a longer period of time; the number of early liver lesions made 18.5% in the high-risk group, and 6.6% (p = 0.02) in the low-risk group. The procedure of laboratory monitoring depending on the degree of risk was offered for early diagnostics of drug-induced liver lesions. |
topic |
tuberculosis treatment drug-induced liver lesions risk factors monitoring |
url |
https://www.tibl-journal.com/jour/article/view/1044 |
work_keys_str_mv |
AT daivanova riskassessmentandmonitoringofhepatotoxicreactionsintuberculosispatients AT seborisov riskassessmentandmonitoringofhepatotoxicreactionsintuberculosispatients |
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1721264067997335552 |