The chromatin remodeling enzyme Chd4 regulates genome architecture in the mouse brain

The mechanisms underlying gene regulation and genome architecture remain poorly understood. Here, the authors investigate the role of chromatin remodelling enzyme Chd4 in granule neurons of the mouse cerebellum and find that conditional knockout of Chd4 preferentially activates enhancers and modulat...

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Main Authors:	Jared V. Goodman, Tomoko Yamada, Yue Yang, Lingchun Kong, Dennis Y. Wu, Guoyan Zhao, Harrison W. Gabel, Azad Bonni
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-07-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-17065-z

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spelling	doaj-8c5f1f247923448eb79492786dde4b162021-07-11T11:45:05ZengNature Publishing GroupNature Communications2041-17232020-07-0111111410.1038/s41467-020-17065-zThe chromatin remodeling enzyme Chd4 regulates genome architecture in the mouse brainJared V. Goodman0Tomoko Yamada1Yue Yang2Lingchun Kong3Dennis Y. Wu4Guoyan Zhao5Harrison W. Gabel6Azad Bonni7Department of Neuroscience, Washington University School of MedicineDepartment of Neuroscience, Washington University School of MedicineDepartment of Neuroscience, Washington University School of MedicineDepartment of Neuroscience, Washington University School of MedicineDepartment of Neuroscience, Washington University School of MedicineDepartment of Neuroscience, Washington University School of MedicineDepartment of Neuroscience, Washington University School of MedicineDepartment of Neuroscience, Washington University School of MedicineThe mechanisms underlying gene regulation and genome architecture remain poorly understood. Here, the authors investigate the role of chromatin remodelling enzyme Chd4 in granule neurons of the mouse cerebellum and find that conditional knockout of Chd4 preferentially activates enhancers and modulates genome architecture at a genome-wide level.https://doi.org/10.1038/s41467-020-17065-z
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Jared V. Goodman Tomoko Yamada Yue Yang Lingchun Kong Dennis Y. Wu Guoyan Zhao Harrison W. Gabel Azad Bonni
spellingShingle	Jared V. Goodman Tomoko Yamada Yue Yang Lingchun Kong Dennis Y. Wu Guoyan Zhao Harrison W. Gabel Azad Bonni The chromatin remodeling enzyme Chd4 regulates genome architecture in the mouse brain Nature Communications
author_facet	Jared V. Goodman Tomoko Yamada Yue Yang Lingchun Kong Dennis Y. Wu Guoyan Zhao Harrison W. Gabel Azad Bonni
author_sort	Jared V. Goodman
title	The chromatin remodeling enzyme Chd4 regulates genome architecture in the mouse brain
title_short	The chromatin remodeling enzyme Chd4 regulates genome architecture in the mouse brain
title_full	The chromatin remodeling enzyme Chd4 regulates genome architecture in the mouse brain
title_fullStr	The chromatin remodeling enzyme Chd4 regulates genome architecture in the mouse brain
title_full_unstemmed	The chromatin remodeling enzyme Chd4 regulates genome architecture in the mouse brain
title_sort	chromatin remodeling enzyme chd4 regulates genome architecture in the mouse brain
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-07-01
description	The mechanisms underlying gene regulation and genome architecture remain poorly understood. Here, the authors investigate the role of chromatin remodelling enzyme Chd4 in granule neurons of the mouse cerebellum and find that conditional knockout of Chd4 preferentially activates enhancers and modulates genome architecture at a genome-wide level.
url	https://doi.org/10.1038/s41467-020-17065-z
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The chromatin remodeling enzyme Chd4 regulates genome architecture in the mouse brain

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