LRPPRC-mediated folding of the mitochondrial transcriptome

LRPPRC-mediated folding of the mitochondrial transcriptome

The mitochondrial genome, being compressed to 16 kb, is an attractive model system to investigate how RNA-binding proteins chaperone mRNA lifecycles. Here the authors use RNase footprinting and PAR-CLIP to show that the LRPPRC–SLIRP complex stabilizes mRNA structures to expose sites required for tra...

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Main Authors: Stefan J. Siira, Henrik Spåhr, Anne-Marie J. Shearwood, Benedetta Ruzzenente, Nils-Göran Larsson, Oliver Rackham, Aleksandra Filipovska
Format: Article
Language:English
Published: Nature Publishing Group 2017-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-01221-z
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spelling doaj-8c6adab0547346b6a630adf12ab05ecd2021-05-11T07:42:06ZengNature Publishing GroupNature Communications2041-17232017-11-018111110.1038/s41467-017-01221-zLRPPRC-mediated folding of the mitochondrial transcriptomeStefan J. Siira0Henrik Spåhr1Anne-Marie J. Shearwood2Benedetta Ruzzenente3Nils-Göran Larsson4Oliver Rackham5Aleksandra Filipovska6Harry Perkins Institute of Medical Research and Centre for Medical Research, The University of Western AustraliaDepartment of Mitochondrial Biology, Max Planck Institute for Biology of AgeingHarry Perkins Institute of Medical Research and Centre for Medical Research, The University of Western AustraliaDepartment of Mitochondrial Biology, Max Planck Institute for Biology of AgeingDepartment of Mitochondrial Biology, Max Planck Institute for Biology of AgeingHarry Perkins Institute of Medical Research and Centre for Medical Research, The University of Western AustraliaHarry Perkins Institute of Medical Research and Centre for Medical Research, The University of Western AustraliaThe mitochondrial genome, being compressed to 16 kb, is an attractive model system to investigate how RNA-binding proteins chaperone mRNA lifecycles. Here the authors use RNase footprinting and PAR-CLIP to show that the LRPPRC–SLIRP complex stabilizes mRNA structures to expose sites required for translation and polyadenylation.https://doi.org/10.1038/s41467-017-01221-z
collection DOAJ
language English
format Article
sources DOAJ
author Stefan J. Siira
Henrik Spåhr
Anne-Marie J. Shearwood
Benedetta Ruzzenente
Nils-Göran Larsson
Oliver Rackham
Aleksandra Filipovska
spellingShingle Stefan J. Siira
Henrik Spåhr
Anne-Marie J. Shearwood
Benedetta Ruzzenente
Nils-Göran Larsson
Oliver Rackham
Aleksandra Filipovska
LRPPRC-mediated folding of the mitochondrial transcriptome
Nature Communications
author_facet Stefan J. Siira
Henrik Spåhr
Anne-Marie J. Shearwood
Benedetta Ruzzenente
Nils-Göran Larsson
Oliver Rackham
Aleksandra Filipovska
author_sort Stefan J. Siira
title LRPPRC-mediated folding of the mitochondrial transcriptome
title_short LRPPRC-mediated folding of the mitochondrial transcriptome
title_full LRPPRC-mediated folding of the mitochondrial transcriptome
title_fullStr LRPPRC-mediated folding of the mitochondrial transcriptome
title_full_unstemmed LRPPRC-mediated folding of the mitochondrial transcriptome
title_sort lrpprc-mediated folding of the mitochondrial transcriptome
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-11-01
description The mitochondrial genome, being compressed to 16 kb, is an attractive model system to investigate how RNA-binding proteins chaperone mRNA lifecycles. Here the authors use RNase footprinting and PAR-CLIP to show that the LRPPRC–SLIRP complex stabilizes mRNA structures to expose sites required for translation and polyadenylation.
url https://doi.org/10.1038/s41467-017-01221-z
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AT benedettaruzzenente lrpprcmediatedfoldingofthemitochondrialtranscriptome
AT nilsgoranlarsson lrpprcmediatedfoldingofthemitochondrialtranscriptome
AT oliverrackham lrpprcmediatedfoldingofthemitochondrialtranscriptome
AT aleksandrafilipovska lrpprcmediatedfoldingofthemitochondrialtranscriptome
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