Brain Volumetric Alterations in Preclinical HIV-Associated Neurocognitive Disorder Using Automatic Brain Quantification and Segmentation Tool
PurposeThis study aimed to determine if people living with HIV (PLWH) in preclinical human immunodeficiency virus (HIV)-associated neurocognitive disorder (HAND), with no clinical symptoms and without decreased daily functioning, suffer from brain volumetric alterations and its patterns.MethodFifty-...
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Frontiers Media S.A.
2021-08-01
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Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2021.713760/full |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ruili Li Ruili Li Yu Qi Lin Shi Lin Shi Wei Wang Aidong Zhang Yishan Luo Wing Kit Kung Zengxin Jiao Guangxue Liu Hongjun Li Longjiang Zhang |
spellingShingle |
Ruili Li Ruili Li Yu Qi Lin Shi Lin Shi Wei Wang Aidong Zhang Yishan Luo Wing Kit Kung Zengxin Jiao Guangxue Liu Hongjun Li Longjiang Zhang Brain Volumetric Alterations in Preclinical HIV-Associated Neurocognitive Disorder Using Automatic Brain Quantification and Segmentation Tool Frontiers in Neuroscience HIV neurocognitive disorder brain volumetric alterations MR imaging T1-weighted imaging |
author_facet |
Ruili Li Ruili Li Yu Qi Lin Shi Lin Shi Wei Wang Aidong Zhang Yishan Luo Wing Kit Kung Zengxin Jiao Guangxue Liu Hongjun Li Longjiang Zhang |
author_sort |
Ruili Li |
title |
Brain Volumetric Alterations in Preclinical HIV-Associated Neurocognitive Disorder Using Automatic Brain Quantification and Segmentation Tool |
title_short |
Brain Volumetric Alterations in Preclinical HIV-Associated Neurocognitive Disorder Using Automatic Brain Quantification and Segmentation Tool |
title_full |
Brain Volumetric Alterations in Preclinical HIV-Associated Neurocognitive Disorder Using Automatic Brain Quantification and Segmentation Tool |
title_fullStr |
Brain Volumetric Alterations in Preclinical HIV-Associated Neurocognitive Disorder Using Automatic Brain Quantification and Segmentation Tool |
title_full_unstemmed |
Brain Volumetric Alterations in Preclinical HIV-Associated Neurocognitive Disorder Using Automatic Brain Quantification and Segmentation Tool |
title_sort |
brain volumetric alterations in preclinical hiv-associated neurocognitive disorder using automatic brain quantification and segmentation tool |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neuroscience |
issn |
1662-453X |
publishDate |
2021-08-01 |
description |
PurposeThis study aimed to determine if people living with HIV (PLWH) in preclinical human immunodeficiency virus (HIV)-associated neurocognitive disorder (HAND), with no clinical symptoms and without decreased daily functioning, suffer from brain volumetric alterations and its patterns.MethodFifty-nine male PLWH at the HAND preclinical stage were evaluated, including 19 subjects with asymptomatic neurocognitive impairment (ANI), 17 subjects with cognitive abnormality that does not reach ANI (Not reach ANI), and 23 subjects with cognitive integrity. Moreover, 23 healthy volunteers were set as the seronegative normal controls (NCs). These individuals underwent sagittal three-dimensional T1-weighted imaging (3D T1WI). Quantified data and volumetric measures of brain structures were automatically segmented and extracted using AccuBrain®. In addition, the multiple linear regression analysis was performed to analyze the relationship of volumes of brain structures and clinical variables in preclinical HAND, and the correlations of the brain volume parameters with different cognitive function states were assessed by Pearson’s correlation analysis.ResultsThe significant difference was shown in the relative volumes of the ventricular system, bilateral lateral ventricle, thalamus, caudate, and left parietal lobe gray matter between the preclinical HAND and NCs. Furthermore, the relative volumes of the bilateral thalamus in preclinical HAND were negatively correlated with attention/working memory (left: r = −0.271, p = 0.042; right: r = −0.273, p = 0.040). Higher age was associated with increased relative volumes of the bilateral lateral ventricle and ventricular system and reduced relative volumes of the left thalamus and parietal lobe gray matter. The lower CD4+/CD8+ ratio was associated with increased relative volumes of the left lateral ventricle and ventricular system. Longer disease course was associated with increased relative volumes of the bilateral thalamus. No significant difference was found among preclinical HAND subgroups in all indices, and the difference between the individual groups (Not reach ANI and Cognitive integrity groups) and NCs was also insignificant. However, there was a significant difference between ANI and NCs in the relative volumes of the bilateral caudate and lateral ventricle.ConclusionMale PLWH at the HAND preclinical stage suffer from brain volumetric alterations. AccuBrain® provides potential value in evaluating HIV-related neurocognitive dysfunction. |
topic |
HIV neurocognitive disorder brain volumetric alterations MR imaging T1-weighted imaging |
url |
https://www.frontiersin.org/articles/10.3389/fnins.2021.713760/full |
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doaj-8c6c985d571f4f418dd568014d98118b2021-08-11T04:41:10ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2021-08-011510.3389/fnins.2021.713760713760Brain Volumetric Alterations in Preclinical HIV-Associated Neurocognitive Disorder Using Automatic Brain Quantification and Segmentation ToolRuili Li0Ruili Li1Yu Qi2Lin Shi3Lin Shi4Wei Wang5Aidong Zhang6Yishan Luo7Wing Kit Kung8Zengxin Jiao9Guangxue Liu10Hongjun Li11Longjiang Zhang12Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Nanjing, ChinaDepartment of Radiology, Beijing Youan Hospital, Capital Medical University, Beijing, ChinaDepartment of Radiology, Beijing Youan Hospital, Capital Medical University, Beijing, ChinaBrainNow Research Institute, Shenzhen, ChinaDepartment of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Hong Kong, Hong KongDepartment of Radiology, Beijing Youan Hospital, Capital Medical University, Beijing, ChinaDepartment of Radiology, Beijing Youan Hospital, Capital Medical University, Beijing, ChinaBrainNow Research Institute, Shenzhen, ChinaBrainNow Research Institute, Shenzhen, ChinaDepartment of Radiology, Beijing Youan Hospital, Capital Medical University, Beijing, ChinaDepartment of Natural Medicines, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, ChinaDepartment of Radiology, Beijing Youan Hospital, Capital Medical University, Beijing, ChinaDepartment of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Nanjing, ChinaPurposeThis study aimed to determine if people living with HIV (PLWH) in preclinical human immunodeficiency virus (HIV)-associated neurocognitive disorder (HAND), with no clinical symptoms and without decreased daily functioning, suffer from brain volumetric alterations and its patterns.MethodFifty-nine male PLWH at the HAND preclinical stage were evaluated, including 19 subjects with asymptomatic neurocognitive impairment (ANI), 17 subjects with cognitive abnormality that does not reach ANI (Not reach ANI), and 23 subjects with cognitive integrity. Moreover, 23 healthy volunteers were set as the seronegative normal controls (NCs). These individuals underwent sagittal three-dimensional T1-weighted imaging (3D T1WI). Quantified data and volumetric measures of brain structures were automatically segmented and extracted using AccuBrain®. In addition, the multiple linear regression analysis was performed to analyze the relationship of volumes of brain structures and clinical variables in preclinical HAND, and the correlations of the brain volume parameters with different cognitive function states were assessed by Pearson’s correlation analysis.ResultsThe significant difference was shown in the relative volumes of the ventricular system, bilateral lateral ventricle, thalamus, caudate, and left parietal lobe gray matter between the preclinical HAND and NCs. Furthermore, the relative volumes of the bilateral thalamus in preclinical HAND were negatively correlated with attention/working memory (left: r = −0.271, p = 0.042; right: r = −0.273, p = 0.040). Higher age was associated with increased relative volumes of the bilateral lateral ventricle and ventricular system and reduced relative volumes of the left thalamus and parietal lobe gray matter. The lower CD4+/CD8+ ratio was associated with increased relative volumes of the left lateral ventricle and ventricular system. Longer disease course was associated with increased relative volumes of the bilateral thalamus. No significant difference was found among preclinical HAND subgroups in all indices, and the difference between the individual groups (Not reach ANI and Cognitive integrity groups) and NCs was also insignificant. However, there was a significant difference between ANI and NCs in the relative volumes of the bilateral caudate and lateral ventricle.ConclusionMale PLWH at the HAND preclinical stage suffer from brain volumetric alterations. AccuBrain® provides potential value in evaluating HIV-related neurocognitive dysfunction.https://www.frontiersin.org/articles/10.3389/fnins.2021.713760/fullHIVneurocognitive disorderbrain volumetric alterationsMR imagingT1-weighted imaging |