Intermittent cold exposure enhances fat accumulation in mice.
Due to its high energy consuming characteristics, brown adipose tissue (BAT) has been suggested as a key player in energy metabolism. Cold exposure is a physiological activator of BAT. Intermittent cold exposure (ICE), unlike persistent exposure, is clinically feasible. The main objective of this st...
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doaj-8c79bd72cec443268179853a8885542c2020-11-25T01:26:59ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0195e9643210.1371/journal.pone.0096432Intermittent cold exposure enhances fat accumulation in mice.Hyung Sun YooLiping QiaoChris BoscoLok-Hei LeongNikki LytleGen-Sheng FengNai-Wen ChiJianhua ShaoDue to its high energy consuming characteristics, brown adipose tissue (BAT) has been suggested as a key player in energy metabolism. Cold exposure is a physiological activator of BAT. Intermittent cold exposure (ICE), unlike persistent exposure, is clinically feasible. The main objective of this study was to investigate whether ICE reduces adiposity in C57BL/6 mice. Surprisingly, we found that ICE actually increased adiposity despite enhancing Ucp1 expression in BAT and inducing beige adipocytes in subcutaneous white adipose tissue. ICE did not alter basal systemic insulin sensitivity, but it increased liver triglyceride content and secretion rate as well as blood triglyceride levels. Gene profiling further demonstrated that ICE, despite suppressing lipogenic gene expression in white adipose tissue and liver during cold exposure, enhanced lipogenesis between the exposure periods. Together, our results indicate that despite enhancing BAT recruitment, ICE in mice increases fat accumulation by stimulating de novo lipogenesis.http://europepmc.org/articles/PMC4008632?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hyung Sun Yoo Liping Qiao Chris Bosco Lok-Hei Leong Nikki Lytle Gen-Sheng Feng Nai-Wen Chi Jianhua Shao |
spellingShingle |
Hyung Sun Yoo Liping Qiao Chris Bosco Lok-Hei Leong Nikki Lytle Gen-Sheng Feng Nai-Wen Chi Jianhua Shao Intermittent cold exposure enhances fat accumulation in mice. PLoS ONE |
author_facet |
Hyung Sun Yoo Liping Qiao Chris Bosco Lok-Hei Leong Nikki Lytle Gen-Sheng Feng Nai-Wen Chi Jianhua Shao |
author_sort |
Hyung Sun Yoo |
title |
Intermittent cold exposure enhances fat accumulation in mice. |
title_short |
Intermittent cold exposure enhances fat accumulation in mice. |
title_full |
Intermittent cold exposure enhances fat accumulation in mice. |
title_fullStr |
Intermittent cold exposure enhances fat accumulation in mice. |
title_full_unstemmed |
Intermittent cold exposure enhances fat accumulation in mice. |
title_sort |
intermittent cold exposure enhances fat accumulation in mice. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2014-01-01 |
description |
Due to its high energy consuming characteristics, brown adipose tissue (BAT) has been suggested as a key player in energy metabolism. Cold exposure is a physiological activator of BAT. Intermittent cold exposure (ICE), unlike persistent exposure, is clinically feasible. The main objective of this study was to investigate whether ICE reduces adiposity in C57BL/6 mice. Surprisingly, we found that ICE actually increased adiposity despite enhancing Ucp1 expression in BAT and inducing beige adipocytes in subcutaneous white adipose tissue. ICE did not alter basal systemic insulin sensitivity, but it increased liver triglyceride content and secretion rate as well as blood triglyceride levels. Gene profiling further demonstrated that ICE, despite suppressing lipogenic gene expression in white adipose tissue and liver during cold exposure, enhanced lipogenesis between the exposure periods. Together, our results indicate that despite enhancing BAT recruitment, ICE in mice increases fat accumulation by stimulating de novo lipogenesis. |
url |
http://europepmc.org/articles/PMC4008632?pdf=render |
work_keys_str_mv |
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