Integrated Genomic Analysis of Chromosomal Alterations and Mutations in B-Cell Acute Lymphoblastic Leukemia Reveals Distinct Genetic Profiles at Relapse

Integrated Genomic Analysis of Chromosomal Alterations and Mutations in B-Cell Acute Lymphoblastic Leukemia Reveals Distinct Genetic Profiles at Relapse

The clonal basis of relapse in B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is complex and not fully understood. Next-generation sequencing (NGS), array comparative genomic hybridization (aCGH), and multiplex ligation-dependent probe amplification (MLPA) were carried out in matched diagno...

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Bibliographic Details
Main Authors: Maribel Forero-Castro, Adrián Montaño, Cristina Robledo, Alfonso García de Coca, José Luis Fuster, Natalia de las Heras, José Antonio Queizán, María Hernández-Sánchez, Luis A. Corchete-Sánchez, Marta Martín-Izquierdo, Jordi Ribera, José-María Ribera, Rocío Benito, Jesús M. Hernández-Rivas
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Diagnostics
Subjects:
acute lymphoblastic leukemia (ALL)
relapse
next-generation sequencing (NGS)
array comparative genomic hybridization (aCGH)
multiplex ligation-dependent probe amplification (MLPA)
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Online Access:https://www.mdpi.com/2075-4418/10/7/455

Internet

https://www.mdpi.com/2075-4418/10/7/455

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