Experimental Study of Antiatherosclerosis Effects with Hederagenin in Rats
The research tries to establish Wistar rat’s model of atherosclerosis for evaluating the antiatherosclerotic effect of hederagenin and exploring its antiatherosclerosis-related mechanisms. The statistical data have shown that hederagenin exhibits multiple pharmacological activities in the treatment...
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Series: | Evidence-Based Complementary and Alternative Medicine |
Online Access: | http://dx.doi.org/10.1155/2015/456354 |
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doaj-8c7d93f622744d24b657a593ace0a1b62020-11-25T00:54:27ZengHindawi LimitedEvidence-Based Complementary and Alternative Medicine1741-427X1741-42882015-01-01201510.1155/2015/456354456354Experimental Study of Antiatherosclerosis Effects with Hederagenin in RatsSu-Hong Lu0Jian-Hua Guan1Yan-Li Huang2Yu-Wei Pan3Wei Yang4Hai Lan5Si Huang6Jing Hu7Guo-Ping Zhao8Medical School, Jinan University, 601 Huangpu Road West, Guangzhou, Guangdong 510632, ChinaMedical School, Jinan University, 601 Huangpu Road West, Guangzhou, Guangdong 510632, ChinaMedical School, Jinan University, 601 Huangpu Road West, Guangzhou, Guangdong 510632, ChinaMedical School, Jinan University, 601 Huangpu Road West, Guangzhou, Guangdong 510632, ChinaMedical School, Jinan University, 601 Huangpu Road West, Guangzhou, Guangdong 510632, ChinaMedical School, Jinan University, 601 Huangpu Road West, Guangzhou, Guangdong 510632, ChinaMedical School, Jinan University, 601 Huangpu Road West, Guangzhou, Guangdong 510632, ChinaThe First Affiliated Hospital of Jinan University, 613 Huangpu Road West, Guangzhou, Guangdong 510632, ChinaMedical School, Jinan University, 601 Huangpu Road West, Guangzhou, Guangdong 510632, ChinaThe research tries to establish Wistar rat’s model of atherosclerosis for evaluating the antiatherosclerotic effect of hederagenin and exploring its antiatherosclerosis-related mechanisms. The statistical data have shown that hederagenin exhibits multiple pharmacological activities in the treatment of hyperlipidemia, antiplatelet aggregation, liver protection, and anti-inflammation, indicating that hederagenin may exert a protective effect on vascular walls by improving lipid metabolism disorders and lipid deposition. The results show that hederagenin can correct the imbalance of endothelial function by inhibiting the release of large amounts of iNOS and increasing eNOS contents and inhibits the IKKβ/NF-κB signaling pathway to reduce the release of IL-6, IFN-γ, TNF-α, and other inflammatory factors. The experimental results indicated that hederagenin can inhibit or ameliorate the pathological changes associated with AS, displaying an excellent preventive function against AS.http://dx.doi.org/10.1155/2015/456354 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Su-Hong Lu Jian-Hua Guan Yan-Li Huang Yu-Wei Pan Wei Yang Hai Lan Si Huang Jing Hu Guo-Ping Zhao |
spellingShingle |
Su-Hong Lu Jian-Hua Guan Yan-Li Huang Yu-Wei Pan Wei Yang Hai Lan Si Huang Jing Hu Guo-Ping Zhao Experimental Study of Antiatherosclerosis Effects with Hederagenin in Rats Evidence-Based Complementary and Alternative Medicine |
author_facet |
Su-Hong Lu Jian-Hua Guan Yan-Li Huang Yu-Wei Pan Wei Yang Hai Lan Si Huang Jing Hu Guo-Ping Zhao |
author_sort |
Su-Hong Lu |
title |
Experimental Study of Antiatherosclerosis Effects with Hederagenin in Rats |
title_short |
Experimental Study of Antiatherosclerosis Effects with Hederagenin in Rats |
title_full |
Experimental Study of Antiatherosclerosis Effects with Hederagenin in Rats |
title_fullStr |
Experimental Study of Antiatherosclerosis Effects with Hederagenin in Rats |
title_full_unstemmed |
Experimental Study of Antiatherosclerosis Effects with Hederagenin in Rats |
title_sort |
experimental study of antiatherosclerosis effects with hederagenin in rats |
publisher |
Hindawi Limited |
series |
Evidence-Based Complementary and Alternative Medicine |
issn |
1741-427X 1741-4288 |
publishDate |
2015-01-01 |
description |
The research tries to establish Wistar rat’s model of atherosclerosis for evaluating the antiatherosclerotic effect of hederagenin and exploring its antiatherosclerosis-related mechanisms. The statistical data have shown that hederagenin exhibits multiple pharmacological activities in the treatment of hyperlipidemia, antiplatelet aggregation, liver protection, and anti-inflammation, indicating that hederagenin may exert a protective effect on vascular walls by improving lipid metabolism disorders and lipid deposition. The results show that hederagenin can correct the imbalance of endothelial function by inhibiting the release of large amounts of iNOS and increasing eNOS contents and inhibits the IKKβ/NF-κB signaling pathway to reduce the release of IL-6, IFN-γ, TNF-α, and other inflammatory factors. The experimental results indicated that hederagenin can inhibit or ameliorate the pathological changes associated with AS, displaying an excellent preventive function against AS. |
url |
http://dx.doi.org/10.1155/2015/456354 |
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