Caveolin-1 reduces HIV-1 infectivity by restoration of HIV Nef mediated impairment of cholesterol efflux by apoA-I

Caveolin-1 reduces HIV-1 infectivity by restoration of HIV Nef mediated impairment of cholesterol efflux by apoA-I

<p>Abstract</p> <p>Background</p> <p>HIV infection results in inhibited cholesterol efflux by apolipoprotein A-I (apoA-I) in macrophages, and this impairment involves Nef mediated down-regulation and redistribution of ATP-binding cassette transporter A1 (ABCA-1). We inv...

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Bibliographic Details
Main Authors: Lin Shanshan, Nadeau Peter E, Wang Xiaomei, Mergia Ayalew
Format: Article
Language:English
Published: BMC 2012-10-01
Series:Retrovirology
Subjects:
HIV
Caveolin-1
Cholesterol efflux
Nef
Apolipoprotein A-I
Online Access:http://www.retrovirology.com/content/9/1/85

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