IFNγ and TNFα synergistically induce apoptosis of mesenchymal stem/stromal cells via the induction of nitric oxide

IFNγ and TNFα synergistically induce apoptosis of mesenchymal stem/stromal cells via the induction of nitric oxide

Abstract Background Mesenchymal stem/stromal cells (MSCs) have been widely used to treat various inflammatory diseases. The immunomodulatory capabilities of MSCs are usually licensed by inflammatory cytokines and may vary depending on the levels and the types of inflammatory cytokines. However, how...

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Bibliographic Details
Main Authors: Xiaolei Li, Bingxue Shang, Ya-nan Li, Yufang Shi, Changshun Shao
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Stem Cell Research & Therapy
Subjects:
Mesenchymal stem/stromal cells
Inflammation
iNOS
Nitric oxide
Autophagy
Apoptosis
Online Access:http://link.springer.com/article/10.1186/s13287-018-1102-z

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