Integrated Analysis of a Noncoding RNA-Associated Competing Endogenous RNA Network in Non-Alcoholic Fatty Liver Disease
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide. Dysregulation of both coding and long noncoding RNAs (lncRNAs) plays crucial role in the pathogenesis and development of the disease. In this study, we identified a profile of dysregulated RNAs using datase...
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2020-01-01
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| Online Access: | https://ieeexplore.ieee.org/document/9085396/ |
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doaj-8c96ea9392e84dbe84782dbf9b4759da2021-03-30T01:55:43ZengIEEEIEEE Access2169-35362020-01-018889778898910.1109/ACCESS.2020.29921099085396Integrated Analysis of a Noncoding RNA-Associated Competing Endogenous RNA Network in Non-Alcoholic Fatty Liver DiseaseFengjie Hao0Junfeng Shi1Yongjun Chen2Xuefeng Gu3https://orcid.org/0000-0002-8718-2067Di Ma4Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Prosthodontics, Shanghai Engineering Research Center of Advanced Dental Technology and Materials, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Ninth People’s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaShanghai Key Laboratory of Molecular Imaging, Collaborative Research Center, Shanghai University of Medicine and Health Sciences, Shanghai, ChinaDepartment of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaNon-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide. Dysregulation of both coding and long noncoding RNAs (lncRNAs) plays crucial role in the pathogenesis and development of the disease. In this study, we identified a profile of dysregulated RNAs using datasets from a public database. By incorporating all interactions between different RNAs, a competing endogenous RNA network was established to further illustrate the regulatory roles of noncoding miRNAs and lncRNAs. Moreover, a functional analysis showed that NAFLD is more closely associated with certain biological processes and pathways. Altogether, these results provide a helpful perspective on NAFLD and may assist future diagnosis and treatment of the disease.https://ieeexplore.ieee.org/document/9085396/Non-alcoholic fatty liver diseasemRNAmiRNAlncRNAceRNA network |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Fengjie Hao Junfeng Shi Yongjun Chen Xuefeng Gu Di Ma |
| spellingShingle |
Fengjie Hao Junfeng Shi Yongjun Chen Xuefeng Gu Di Ma Integrated Analysis of a Noncoding RNA-Associated Competing Endogenous RNA Network in Non-Alcoholic Fatty Liver Disease IEEE Access Non-alcoholic fatty liver disease mRNA miRNA lncRNA ceRNA network |
| author_facet |
Fengjie Hao Junfeng Shi Yongjun Chen Xuefeng Gu Di Ma |
| author_sort |
Fengjie Hao |
| title |
Integrated Analysis of a Noncoding RNA-Associated Competing Endogenous RNA Network in Non-Alcoholic Fatty Liver Disease |
| title_short |
Integrated Analysis of a Noncoding RNA-Associated Competing Endogenous RNA Network in Non-Alcoholic Fatty Liver Disease |
| title_full |
Integrated Analysis of a Noncoding RNA-Associated Competing Endogenous RNA Network in Non-Alcoholic Fatty Liver Disease |
| title_fullStr |
Integrated Analysis of a Noncoding RNA-Associated Competing Endogenous RNA Network in Non-Alcoholic Fatty Liver Disease |
| title_full_unstemmed |
Integrated Analysis of a Noncoding RNA-Associated Competing Endogenous RNA Network in Non-Alcoholic Fatty Liver Disease |
| title_sort |
integrated analysis of a noncoding rna-associated competing endogenous rna network in non-alcoholic fatty liver disease |
| publisher |
IEEE |
| series |
IEEE Access |
| issn |
2169-3536 |
| publishDate |
2020-01-01 |
| description |
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide. Dysregulation of both coding and long noncoding RNAs (lncRNAs) plays crucial role in the pathogenesis and development of the disease. In this study, we identified a profile of dysregulated RNAs using datasets from a public database. By incorporating all interactions between different RNAs, a competing endogenous RNA network was established to further illustrate the regulatory roles of noncoding miRNAs and lncRNAs. Moreover, a functional analysis showed that NAFLD is more closely associated with certain biological processes and pathways. Altogether, these results provide a helpful perspective on NAFLD and may assist future diagnosis and treatment of the disease. |
| topic |
Non-alcoholic fatty liver disease mRNA miRNA lncRNA ceRNA network |
| url |
https://ieeexplore.ieee.org/document/9085396/ |
| work_keys_str_mv |
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