GM1 Induced the inflammatory response related to the Raf-1/MEK1/2/ERK1/2 pathway in co-culture of pig mesenchymal stem cells with RAW264.7

GM1 Induced the inflammatory response related to the Raf-1/MEK1/2/ERK1/2 pathway in co-culture of pig mesenchymal stem cells with RAW264.7

Pig-human xenotransplantation can trigger cell-mediated immune responses. We explored the role of gangliosides in inflammation related to immune rejection in xenotransplantation. Co-culture of xenogeneic cells (pig-MSCs and RAW264.7) was used to emulate xenotransplantation conditions. MTT assay resu...

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Bibliographic Details
Main Authors: Dong Hoon Kwak, You Na Seo, Ju Hyoung Lee, Soon Ju Park, Young Ho Cho, Ji-Su Kim, Sun-Uk Kim, Young-Kug Choo
Format: Article
Language:English
Published: Taylor & Francis Group 2018-05-01
Series:Animal Cells and Systems
Subjects:
GM1
xenotransplantation
inflammation
MAPK
pig-mesenchymal stem cells
Online Access:http://dx.doi.org/10.1080/19768354.2018.1453546

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