Modulatory effects of rutin on biochemical and hematological parameters in hypercholesterolemic Golden Syrian hamsters
Flavonoids have been reported to exhibit several pharmacological properties, mainly in cardiovascular and inflammatory diseases. In the present study, we observed that rutin, a known glycosylated flavonoid isolated from Dimorphandra mollis, had a lowering effect on plasma triglyceride levels of diet...
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Academia Brasileira de Ciências
2009-03-01
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doaj-8c9abfaacb4b4168a5e3b75604211e242020-11-24T23:06:07ZengAcademia Brasileira de CiênciasAnais da Academia Brasileira de Ciências0001-37651678-26902009-03-01811677210.1590/S0001-37652009000100009Modulatory effects of rutin on biochemical and hematological parameters in hypercholesterolemic Golden Syrian hamstersAlexandre KanashiroDaiani C.O. AndradeLuciana M. KabeyaWalter M. TuratoLucia H. FaccioliSérgio A. UyemuraYara M. Lucisano-ValimFlavonoids have been reported to exhibit several pharmacological properties, mainly in cardiovascular and inflammatory diseases. In the present study, we observed that rutin, a known glycosylated flavonoid isolated from Dimorphandra mollis, had a lowering effect on plasma triglyceride levels of diet-induced hypercholesterolemic Golden Syrian hamsters, but did not change total cholesterol and high-density lipoprotein cholesterol levels. Moreover, high-fat or rutin supplemented diets showed no immunotoxic effects, since no significant changes were observed on total white blood cells, granulocytes and mononuclear cells, as well as on the neutrophil apoptosis degree, when compared to untreated animals. Therefore, rutin seems to be a selective and non-toxic modulator of hypercholesterolemia, which can be promising for the development of new drugs.<br>Os flavonóides possuem diversas propriedades farmacológicas, principalmente nas doenças cardiovasculares e inflamatórias. No presente estudo, observamos que a rutina, um conhecido flavonóide glicosilado isolado da Dimorphandra mollis, diminuiu o nível de triglicerídeos plasmáticos em hamsters Golden Syrian hipercolesterolêmicos sem alterar os níveis de colesterol total e colesterol HDL. Além disso, observamos que dietas hipercolesterolêmicas ou suplementadas com rutina não apresentaram efeito imunotóxico, uma vez que nenhuma alteração significativa foi observada nos leucócitos totais, granulócitos e células mononucleares, bem como no grau de neutrófilos em apoptose, quando comparado com animais não tratados. Portanto, a rutina parece ser um modulador seletivo e não tóxico da hipercolesterolemia, o que pode ser promissor para o desenvolvimento de novos fármacos.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652009000100009rutinahamster Golden SyrianhipercolesterolemiaateroscleroseapoptoseDimorphandra mollisrutinGolden Syrian hamsterhypercholesterolemiaatherosclerosisapoptosisDimorphandra mollis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Alexandre Kanashiro Daiani C.O. Andrade Luciana M. Kabeya Walter M. Turato Lucia H. Faccioli Sérgio A. Uyemura Yara M. Lucisano-Valim |
spellingShingle |
Alexandre Kanashiro Daiani C.O. Andrade Luciana M. Kabeya Walter M. Turato Lucia H. Faccioli Sérgio A. Uyemura Yara M. Lucisano-Valim Modulatory effects of rutin on biochemical and hematological parameters in hypercholesterolemic Golden Syrian hamsters Anais da Academia Brasileira de Ciências rutina hamster Golden Syrian hipercolesterolemia aterosclerose apoptose Dimorphandra mollis rutin Golden Syrian hamster hypercholesterolemia atherosclerosis apoptosis Dimorphandra mollis |
author_facet |
Alexandre Kanashiro Daiani C.O. Andrade Luciana M. Kabeya Walter M. Turato Lucia H. Faccioli Sérgio A. Uyemura Yara M. Lucisano-Valim |
author_sort |
Alexandre Kanashiro |
title |
Modulatory effects of rutin on biochemical and hematological parameters in hypercholesterolemic Golden Syrian hamsters |
title_short |
Modulatory effects of rutin on biochemical and hematological parameters in hypercholesterolemic Golden Syrian hamsters |
title_full |
Modulatory effects of rutin on biochemical and hematological parameters in hypercholesterolemic Golden Syrian hamsters |
title_fullStr |
Modulatory effects of rutin on biochemical and hematological parameters in hypercholesterolemic Golden Syrian hamsters |
title_full_unstemmed |
Modulatory effects of rutin on biochemical and hematological parameters in hypercholesterolemic Golden Syrian hamsters |
title_sort |
modulatory effects of rutin on biochemical and hematological parameters in hypercholesterolemic golden syrian hamsters |
publisher |
Academia Brasileira de Ciências |
series |
Anais da Academia Brasileira de Ciências |
issn |
0001-3765 1678-2690 |
publishDate |
2009-03-01 |
description |
Flavonoids have been reported to exhibit several pharmacological properties, mainly in cardiovascular and inflammatory diseases. In the present study, we observed that rutin, a known glycosylated flavonoid isolated from Dimorphandra mollis, had a lowering effect on plasma triglyceride levels of diet-induced hypercholesterolemic Golden Syrian hamsters, but did not change total cholesterol and high-density lipoprotein cholesterol levels. Moreover, high-fat or rutin supplemented diets showed no immunotoxic effects, since no significant changes were observed on total white blood cells, granulocytes and mononuclear cells, as well as on the neutrophil apoptosis degree, when compared to untreated animals. Therefore, rutin seems to be a selective and non-toxic modulator of hypercholesterolemia, which can be promising for the development of new drugs.<br>Os flavonóides possuem diversas propriedades farmacológicas, principalmente nas doenças cardiovasculares e inflamatórias. No presente estudo, observamos que a rutina, um conhecido flavonóide glicosilado isolado da Dimorphandra mollis, diminuiu o nível de triglicerídeos plasmáticos em hamsters Golden Syrian hipercolesterolêmicos sem alterar os níveis de colesterol total e colesterol HDL. Além disso, observamos que dietas hipercolesterolêmicas ou suplementadas com rutina não apresentaram efeito imunotóxico, uma vez que nenhuma alteração significativa foi observada nos leucócitos totais, granulócitos e células mononucleares, bem como no grau de neutrófilos em apoptose, quando comparado com animais não tratados. Portanto, a rutina parece ser um modulador seletivo e não tóxico da hipercolesterolemia, o que pode ser promissor para o desenvolvimento de novos fármacos. |
topic |
rutina hamster Golden Syrian hipercolesterolemia aterosclerose apoptose Dimorphandra mollis rutin Golden Syrian hamster hypercholesterolemia atherosclerosis apoptosis Dimorphandra mollis |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652009000100009 |
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