Clinical characteristics of 23 cases of meningeal carcinomatosis
Objective To investigate the clinical characteristics of meningeal carcinomatosis with nervous system syndrome as initial symptom. Methods Clinical data, laboratory and imageing examinations were retrospectively analyzed in 23 patients of meningeal carcinomatosis from June 2009 to December 2017. Res...
Main Authors: | , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Tianjin Huanhu Hospital
2019-08-01
|
Series: | Chinese Journal of Contemporary Neurology and Neurosurgery |
Subjects: | |
Online Access: | http://www.cjcnn.org/index.php/cjcnn/article/view/1999 |
id |
doaj-8cb1f906a41d423ebbd0933f003be401 |
---|---|
record_format |
Article |
spelling |
doaj-8cb1f906a41d423ebbd0933f003be4012020-11-24T21:29:49ZengTianjin Huanhu HospitalChinese Journal of Contemporary Neurology and Neurosurgery1672-67311672-67312019-08-0119859760210.3969/j.issn.1672⁃6731.2019.08.010Clinical characteristics of 23 cases of meningeal carcinomatosisBo LI0Zhan⁃hang WANG 1Shao⁃qiang XU 2Chun⁃xia HUANG 3Yu⁃zhou WANG4Meng⁃qiu PAN 5Jin⁃long YE6Bo⁃yong CHEN 7Sha⁃sha CHENG 8Department of Neurology, Guangdong 999 Brain Hospital, Guangzhou 510510, Guangdong, ChinaDepartment of Neurology, Guangdong 999 Brain Hospital, Guangzhou 510510, Guangdong, ChinaDepartment of Clinical Laboratory, Guangdong 999 Brain Hospital, Guangzhou 510510, Guangdong, ChinaDepartment of Clinical Laboratory, Guangdong 999 Brain Hospital, Guangzhou 510510, Guangdong, ChinaDepartment of Neurology, Guangdong 999 Brain Hospital, Guangzhou 510510, Guangdong, ChinaDepartment of Neurology, Guangdong 999 Brain Hospital, Guangzhou 510510, Guangdong, ChinaDepartment of Neurology, Guangdong 999 Brain Hospital, Guangzhou 510510, Guangdong, ChinaDepartment of Neurology, Guangdong 999 Brain Hospital, Guangzhou 510510, Guangdong, ChinaDepartment of Clinical Laboratory, Guangdong 999 Brain Hospital, Guangzhou 510510, Guangdong, ChinaObjective To investigate the clinical characteristics of meningeal carcinomatosis with nervous system syndrome as initial symptom. Methods Clinical data, laboratory and imageing examinations were retrospectively analyzed in 23 patients of meningeal carcinomatosis from June 2009 to December 2017. Results Twenty patients (86.96%) had headache as initial symptom and 12 (52.17%) had headache with vomiting. Head enhanced MRI showed obvious enhancement in meningeal lesions,and 13 cases (59.09%) had meningeal enhancement with enlargement of ventricular system; CT showed enlargement of supratentorial ventricular system (1 case). About 65.22% (15/23) primary lesions were originated from lungcancer,and others were or iginated from colon cancer,hematological lymphoma,gastric cancer, spinal astrocytoma (4.35%, 1/23 respectively), and some unknown origin (17.39%, 4/23). About 82.61% (19/23) patients cerebrospinal fluid pressure increased obviously, Tumor markers especially carcinoembryonic antigen (CEA) were mostly increased in serum (11/17) and cerebrospinal fluid (7/10). Conclusions Headache and vomiting are the most common clinical symptoms of meningeal carcinomatosis. Enhanced MRI shows meningeal enhancement or communicating hydrocephalus. Cerebrospinal fluid pressure tends to increase significantly. Carcinoembryonic antigen is significantly increased in serum and cerebrospinal fluid. Primary lesions of meningeal carcinomatosis mostly originate fromlungcancer. Finding tumor cells in cerebrospinal fluid is the" golden standard" of diagnosis.http://www.cjcnn.org/index.php/cjcnn/article/view/1999Meningeal neoplasms; Neoplasm metastasis; Magnetic resonance imaging; Biomarkerstumor |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Bo LI Zhan⁃hang WANG Shao⁃qiang XU Chun⁃xia HUANG Yu⁃zhou WANG Meng⁃qiu PAN Jin⁃long YE Bo⁃yong CHEN Sha⁃sha CHENG |
spellingShingle |
Bo LI Zhan⁃hang WANG Shao⁃qiang XU Chun⁃xia HUANG Yu⁃zhou WANG Meng⁃qiu PAN Jin⁃long YE Bo⁃yong CHEN Sha⁃sha CHENG Clinical characteristics of 23 cases of meningeal carcinomatosis Chinese Journal of Contemporary Neurology and Neurosurgery Meningeal neoplasms; Neoplasm metastasis; Magnetic resonance imaging; Biomarkers tumor |
author_facet |
Bo LI Zhan⁃hang WANG Shao⁃qiang XU Chun⁃xia HUANG Yu⁃zhou WANG Meng⁃qiu PAN Jin⁃long YE Bo⁃yong CHEN Sha⁃sha CHENG |
author_sort |
Bo LI |
title |
Clinical characteristics of 23 cases of meningeal carcinomatosis |
title_short |
Clinical characteristics of 23 cases of meningeal carcinomatosis |
title_full |
Clinical characteristics of 23 cases of meningeal carcinomatosis |
title_fullStr |
Clinical characteristics of 23 cases of meningeal carcinomatosis |
title_full_unstemmed |
Clinical characteristics of 23 cases of meningeal carcinomatosis |
title_sort |
clinical characteristics of 23 cases of meningeal carcinomatosis |
publisher |
Tianjin Huanhu Hospital |
series |
Chinese Journal of Contemporary Neurology and Neurosurgery |
issn |
1672-6731 1672-6731 |
publishDate |
2019-08-01 |
description |
Objective To investigate the clinical characteristics of meningeal carcinomatosis with nervous system syndrome as initial symptom. Methods Clinical data, laboratory and imageing examinations were retrospectively analyzed in 23 patients of meningeal carcinomatosis from June 2009 to December 2017. Results Twenty patients (86.96%) had headache as initial symptom and 12 (52.17%) had headache with vomiting. Head enhanced MRI showed obvious enhancement in meningeal lesions,and 13 cases (59.09%) had meningeal enhancement with enlargement of ventricular system; CT showed enlargement of supratentorial ventricular system (1 case). About 65.22% (15/23) primary lesions were originated from lungcancer,and others were or iginated from colon cancer,hematological lymphoma,gastric cancer, spinal astrocytoma (4.35%, 1/23 respectively), and some unknown origin (17.39%, 4/23). About 82.61% (19/23) patients cerebrospinal fluid pressure increased obviously, Tumor markers especially carcinoembryonic antigen (CEA) were mostly increased in serum (11/17) and cerebrospinal fluid (7/10). Conclusions Headache and vomiting are the most common clinical symptoms of meningeal carcinomatosis. Enhanced MRI shows meningeal enhancement or communicating hydrocephalus. Cerebrospinal fluid pressure tends to increase significantly. Carcinoembryonic antigen is significantly increased in serum and cerebrospinal fluid. Primary lesions of meningeal carcinomatosis mostly originate fromlungcancer. Finding tumor cells in cerebrospinal fluid is the" golden standard" of diagnosis. |
topic |
Meningeal neoplasms; Neoplasm metastasis; Magnetic resonance imaging; Biomarkers tumor |
url |
http://www.cjcnn.org/index.php/cjcnn/article/view/1999 |
work_keys_str_mv |
AT boli clinicalcharacteristicsof23casesofmeningealcarcinomatosis AT zhanhangwang clinicalcharacteristicsof23casesofmeningealcarcinomatosis AT shaoqiangxu clinicalcharacteristicsof23casesofmeningealcarcinomatosis AT chunxiahuang clinicalcharacteristicsof23casesofmeningealcarcinomatosis AT yuzhouwang clinicalcharacteristicsof23casesofmeningealcarcinomatosis AT mengqiupan clinicalcharacteristicsof23casesofmeningealcarcinomatosis AT jinlongye clinicalcharacteristicsof23casesofmeningealcarcinomatosis AT boyongchen clinicalcharacteristicsof23casesofmeningealcarcinomatosis AT shashacheng clinicalcharacteristicsof23casesofmeningealcarcinomatosis |
_version_ |
1725965634683011072 |