Evaluation of p27 Expression in Salivary Gland Neoplasms; A Step Forward in Unveiling the Role of p27

• Main Authors: Nikhil I. Malgaonkar, Abdulwahab Abuderman, MY Kharma, SA Al-Maweri, NA. Alaizari, MA. Altamimi, S. Darwish, Bassel Tarakji
• Format: Article
• Language: English
• Published: JCDR Research and Publications Private Limited 2016-07-01
• Series: Journal of Clinical and Diagnostic Research
• Subjects: adenoid cystic carcinomas; cyclin dependent kinase inhibitor; mucoepidermoid carcinomas; pleomorphic adenomas
• Online Access: https://jcdr.net/articles/PDF/8071/16719_CE(EK)_F(AK)_PF1(ACAK)_PFA(AK)_PF2(PAG).pdf

Introduction: Salivary gland neoplasms are not uncommon lesions that are seen in the head and neck region. The role of cell cycle regulators as well as that of oncogenes remains unexplored in the pathogenesis of these neoplasms. Aim: Present study was conducted to evaluate the expression of p27 in the three common salivary gland neoplasms. Materials and Methods: A total of 34 cases (19 pleomorphic adenoma, 8 mucoepidermoid carcinoma and 7 adenoid cystic carcinoma) were included. The sections were subjected to p27 staining and rated for the expression. Results: Of the total 52.6% of pleomorphic adenoma cases, 25% of mucoepidermoid carcinoma cases and only 14.2% of adenoid cystic carcinoma cases showed strong expression suggesting variable p27 expression in both malignant neoplasms. Normal salivary gland tissue was stained as a positive control for the evaluation. Conclusion: The results of the study suggest an important role for p27 in pathogenesis of mucoepidermoid carcinoma as well as adenoid cystic carcinoma while its role in pathogenesis of pleomorphic adenoma remains questionable keeping in view the strong expression of p27 in the same.