Production of a New Cyclic Depsipeptide by the Culture Broth of <i>Staphylococcus</i> sp. Isolated from <i>Corallina</i> <i>officinalis</i> L.

• Main Authors: Reda F. A. Abdelhameed, Sameh S. Elhady, Ahmad O. Noor, Diena M. Almasri, Alaa A. Bagalagel, Galal T. Maatooq, Amgad I. M. Khedr, Koji Yamada
• Format: Article
• Language: English
• Published: MDPI AG 2019-11-01
• Series: Metabolites
• Subjects: <i>corallina officinalis</i>; <i>staphylococcus</i> sp.; cyclic depsipeptide; antimicrobial assay
• Online Access: https://www.mdpi.com/2218-1989/9/11/273
• ISSN: 2218-1989

A new cyclic depsipeptide (<b>1</b>) has been isolated from culture broth of <i>Staphylococcus</i> sp. (No. P-100826-4-6) derived from <i>Corallina officinalis</i> L., together with the known compounds indol-3-carboxylic acid (<b>2</b>), 1,5-dideoxy-3-C-methyl arabinitol (<b>3</b>), thymine (<b>4</b>), uracil (<b>5</b>), cyclo (L-pro-L-omet) (<b>6</b>) and macrolactin B (<b>7</b>). The structure of (<b>1</b>) was established to be cyclo (2&#945;, 3-diaminopropoinc acid-L-Asn-3-&#946;-hydroxy-5-methyl-tetradecanoic acid-L-Leu¹-L-Asp-L-Val-L-Leu²-L-Leu³) by extensive spectroscopic techniques including ¹H NMR, ¹³C NMR, ¹H‒¹H COSY, HMBC, HSQC, NOESY, and HRFABMS. The antimicrobial activities of compounds <b>1&#8722;7</b> were evaluated. Compounds <b>1&#8722;5</b>, and <b>7</b> showed moderate antimicrobial activity while compound <b>6</b> exhibited a potent antimicrobial and antifungal activities.