Distinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamide
Enzalutamide, an approved drug for prostate cancer, acts on TMPRSS2 expression, a key mediator for SARS-CoV-2 infection. Here, the authors characterize the anti-SARS-CoV-2 effects of Enzalutamide in prostate cancer cells, lung cancer cells, human lung organoids and in hACE2-transduced Tmprss2 knocko...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2021-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-21171-x |
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doaj-8cd722a7f3344c2295d560f85a3a6ec3 |
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Article |
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DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Fei Li Ming Han Pengfei Dai Wei Xu Juan He Xiaoting Tao Yang Wu Xinyuan Tong Xinyi Xia Wangxin Guo Yunjiao Zhou Yunguang Li Yiqin Zhu Xiaoyu Zhang Zhuang Liu Rebiguli Aji Xia Cai Yutang Li Di Qu Yu Chen Shibo Jiang Qiao Wang Hongbin Ji Youhua Xie Yihua Sun Lu Lu Dong Gao |
| spellingShingle |
Fei Li Ming Han Pengfei Dai Wei Xu Juan He Xiaoting Tao Yang Wu Xinyuan Tong Xinyi Xia Wangxin Guo Yunjiao Zhou Yunguang Li Yiqin Zhu Xiaoyu Zhang Zhuang Liu Rebiguli Aji Xia Cai Yutang Li Di Qu Yu Chen Shibo Jiang Qiao Wang Hongbin Ji Youhua Xie Yihua Sun Lu Lu Dong Gao Distinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamide Nature Communications |
| author_facet |
Fei Li Ming Han Pengfei Dai Wei Xu Juan He Xiaoting Tao Yang Wu Xinyuan Tong Xinyi Xia Wangxin Guo Yunjiao Zhou Yunguang Li Yiqin Zhu Xiaoyu Zhang Zhuang Liu Rebiguli Aji Xia Cai Yutang Li Di Qu Yu Chen Shibo Jiang Qiao Wang Hongbin Ji Youhua Xie Yihua Sun Lu Lu Dong Gao |
| author_sort |
Fei Li |
| title |
Distinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamide |
| title_short |
Distinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamide |
| title_full |
Distinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamide |
| title_fullStr |
Distinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamide |
| title_full_unstemmed |
Distinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamide |
| title_sort |
distinct mechanisms for tmprss2 expression explain organ-specific inhibition of sars-cov-2 infection by enzalutamide |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2021-02-01 |
| description |
Enzalutamide, an approved drug for prostate cancer, acts on TMPRSS2 expression, a key mediator for SARS-CoV-2 infection. Here, the authors characterize the anti-SARS-CoV-2 effects of Enzalutamide in prostate cancer cells, lung cancer cells, human lung organoids and in hACE2-transduced Tmprss2 knockout mice and show lack antiviral action in human lung cells and human lung organoids, likely due to the AR-independent TMPRSS2 expression in mouse and human lung epithelial cells. |
| url |
https://doi.org/10.1038/s41467-021-21171-x |
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doaj-8cd722a7f3344c2295d560f85a3a6ec32021-02-14T12:12:28ZengNature Publishing GroupNature Communications2041-17232021-02-0112111410.1038/s41467-021-21171-xDistinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamideFei Li0Ming Han1Pengfei Dai2Wei Xu3Juan He4Xiaoting Tao5Yang Wu6Xinyuan Tong7Xinyi Xia8Wangxin Guo9Yunjiao Zhou10Yunguang Li11Yiqin Zhu12Xiaoyu Zhang13Zhuang Liu14Rebiguli Aji15Xia Cai16Yutang Li17Di Qu18Yu Chen19Shibo Jiang20Qiao Wang21Hongbin Ji22Youhua Xie23Yihua Sun24Lu Lu25Dong Gao26State Key Laboratory of Cell Biology, Shanghai Key Laboratory of Molecular Andrology, Shanghai Institute of Biochemistry and Cell Biology, CAS Center for Excellence in Molecular Cell Science, Chinese Academy of SciencesState Key Laboratory of Cell Biology, Shanghai Key Laboratory of Molecular Andrology, Shanghai Institute of Biochemistry and Cell Biology, CAS Center for Excellence in Molecular Cell Science, Chinese Academy of SciencesState Key Laboratory of Cell Biology, Shanghai Key Laboratory of Molecular Andrology, Shanghai Institute of Biochemistry and Cell Biology, CAS Center for Excellence in Molecular Cell Science, Chinese Academy of SciencesKey Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences and Biosafety Level 3 Laboratory, Shanghai Medical College, Fudan UniversityState Key Laboratory of Cell Biology, Shanghai Key Laboratory of Molecular Andrology, Shanghai Institute of Biochemistry and Cell Biology, CAS Center for Excellence in Molecular Cell Science, Chinese Academy of SciencesDepartment of Thoracic Surgery, Fudan University Shanghai Cancer CenterKey Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences and Biosafety Level 3 Laboratory, Shanghai Medical College, Fudan UniversityState Key Laboratory of Cell Biology, Shanghai Key Laboratory of Molecular Andrology, Shanghai Institute of Biochemistry and Cell Biology, CAS Center for Excellence in Molecular Cell Science, Chinese Academy of SciencesState Key Laboratory of Cell Biology, Shanghai Key Laboratory of Molecular Andrology, Shanghai Institute of Biochemistry and Cell Biology, CAS Center for Excellence in Molecular Cell Science, Chinese Academy of SciencesState Key Laboratory of Cell Biology, Shanghai Key Laboratory of Molecular Andrology, Shanghai Institute of Biochemistry and Cell Biology, CAS Center for Excellence in Molecular Cell Science, Chinese Academy of SciencesKey Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences and Biosafety Level 3 Laboratory, Shanghai Medical College, Fudan UniversityState Key Laboratory of Cell Biology, Shanghai Key Laboratory of Molecular Andrology, Shanghai Institute of Biochemistry and Cell Biology, CAS Center for Excellence in Molecular Cell Science, Chinese Academy of SciencesState Key Laboratory of Cell Biology, Shanghai Key Laboratory of Molecular Andrology, Shanghai Institute of Biochemistry and Cell Biology, CAS Center for Excellence in Molecular Cell Science, Chinese Academy of SciencesState Key Laboratory of Cell Biology, Shanghai Key Laboratory of Molecular Andrology, Shanghai Institute of Biochemistry and Cell Biology, CAS Center for Excellence in Molecular Cell Science, Chinese Academy of SciencesState Key Laboratory of Cell Biology, Shanghai Key Laboratory of Molecular Andrology, Shanghai Institute of Biochemistry and Cell Biology, CAS Center for Excellence in Molecular Cell Science, Chinese Academy of SciencesState Key Laboratory of Cell Biology, Shanghai Key Laboratory of Molecular Andrology, Shanghai Institute of Biochemistry and Cell Biology, CAS Center for Excellence in Molecular Cell Science, Chinese Academy of SciencesKey Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences and Biosafety Level 3 Laboratory, Shanghai Medical College, Fudan UniversityKey Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences and Biosafety Level 3 Laboratory, Shanghai Medical College, Fudan UniversityKey Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences and Biosafety Level 3 Laboratory, Shanghai Medical College, Fudan UniversityHuman Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer CenterKey Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences and Biosafety Level 3 Laboratory, Shanghai Medical College, Fudan UniversityKey Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences and Biosafety Level 3 Laboratory, Shanghai Medical College, Fudan UniversityState Key Laboratory of Cell Biology, Shanghai Key Laboratory of Molecular Andrology, Shanghai Institute of Biochemistry and Cell Biology, CAS Center for Excellence in Molecular Cell Science, Chinese Academy of SciencesKey Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences and Biosafety Level 3 Laboratory, Shanghai Medical College, Fudan UniversityDepartment of Thoracic Surgery, Fudan University Shanghai Cancer CenterKey Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences and Biosafety Level 3 Laboratory, Shanghai Medical College, Fudan UniversityState Key Laboratory of Cell Biology, Shanghai Key Laboratory of Molecular Andrology, Shanghai Institute of Biochemistry and Cell Biology, CAS Center for Excellence in Molecular Cell Science, Chinese Academy of SciencesEnzalutamide, an approved drug for prostate cancer, acts on TMPRSS2 expression, a key mediator for SARS-CoV-2 infection. Here, the authors characterize the anti-SARS-CoV-2 effects of Enzalutamide in prostate cancer cells, lung cancer cells, human lung organoids and in hACE2-transduced Tmprss2 knockout mice and show lack antiviral action in human lung cells and human lung organoids, likely due to the AR-independent TMPRSS2 expression in mouse and human lung epithelial cells.https://doi.org/10.1038/s41467-021-21171-x |