The MicroRNA Expression Profile Differs Between Erythrodermic Mycosis Fungoides and Sézary Syndrome
It is difficult to distinguish erythrodermic mycosis fungoides from Sézary syndrome due to their similar clinical and histological features. The main purpose of this study was to investigate whether microRNA expression profiles in lesional skin could discriminate patients with erythrodermic mycosis...
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Society for Publication of Acta Dermato-Venereologica
2019-09-01
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https://www.medicaljournals.se/acta/content/html/10.2340/00015555-3306
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doaj-8ced5b6d76bf48659ea0fbf7fd7f76d22020-11-24T21:36:15ZengSociety for Publication of Acta Dermato-VenereologicaActa Dermato-Venereologica0001-55551651-20572019-09-0199121148115310.2340/00015555-33065572The MicroRNA Expression Profile Differs Between Erythrodermic Mycosis Fungoides and Sézary SyndromeAnne Hald Rittig0Lise M. LindahlClaus JohansenPamela CelisNiels ØdumLars IversenThomas Litman Department of Dermatology, Aarhus University Hospital, DK-8200 Aarhus N, Denmark. Annehald@clin.au.dk. It is difficult to distinguish erythrodermic mycosis fungoides from Sézary syndrome due to their similar clinical and histological features. The main purpose of this study was to investigate whether microRNA expression profiles in lesional skin could discriminate patients with erythrodermic mycosis fungoides from those with Sézary syndrome. A further aim was to assess whether the microRNA expression profiles in erythrodermic mycosis fungoides skin was more comparable to microRNA expression profiles of Sézary syndrome or early-stage mycosis fungoides. RNA was extracted from diagnostic skin biopsies, followed by quantitative reverse transcription polymerase chain reaction analysis of 383 microRNAs. Twenty-seven microRNAs were significantly differentially expressed between erythrodermic mycosis fungoides and Sézary syndrome. Moreover, erythrodermic mycosis fungoides showed microRNA features overlapping with Sézary syndrome and early-stage mycosis fungoides, although hierarchical cluster analysis co-clustered erythrodermic mycosis fungoides with early-stage mycosis fungoides rather than with Sézary syndrome. These findings underscore that erythrodermic mycosis fungoides and Sézary syndrome are different diseases. https://www.medicaljournals.se/acta/content/html/10.2340/00015555-3306 mycosis fungoides, sézary syndrome, cutaneous t cell lymphoma, microrna |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Anne Hald Rittig Lise M. Lindahl Claus Johansen Pamela Celis Niels Ødum Lars Iversen Thomas Litman |
spellingShingle |
Anne Hald Rittig Lise M. Lindahl Claus Johansen Pamela Celis Niels Ødum Lars Iversen Thomas Litman The MicroRNA Expression Profile Differs Between Erythrodermic Mycosis Fungoides and Sézary Syndrome Acta Dermato-Venereologica mycosis fungoides, sézary syndrome, cutaneous t cell lymphoma, microrna |
author_facet |
Anne Hald Rittig Lise M. Lindahl Claus Johansen Pamela Celis Niels Ødum Lars Iversen Thomas Litman |
author_sort |
Anne Hald Rittig |
title |
The MicroRNA Expression Profile Differs Between Erythrodermic Mycosis Fungoides and Sézary Syndrome |
title_short |
The MicroRNA Expression Profile Differs Between Erythrodermic Mycosis Fungoides and Sézary Syndrome |
title_full |
The MicroRNA Expression Profile Differs Between Erythrodermic Mycosis Fungoides and Sézary Syndrome |
title_fullStr |
The MicroRNA Expression Profile Differs Between Erythrodermic Mycosis Fungoides and Sézary Syndrome |
title_full_unstemmed |
The MicroRNA Expression Profile Differs Between Erythrodermic Mycosis Fungoides and Sézary Syndrome |
title_sort |
microrna expression profile differs between erythrodermic mycosis fungoides and sézary syndrome |
publisher |
Society for Publication of Acta Dermato-Venereologica |
series |
Acta Dermato-Venereologica |
issn |
0001-5555 1651-2057 |
publishDate |
2019-09-01 |
description |
It is difficult to distinguish erythrodermic mycosis fungoides from Sézary syndrome due to their similar clinical and histological features. The main purpose of this study was to investigate whether microRNA expression profiles in lesional skin could discriminate patients with erythrodermic mycosis fungoides from those with Sézary syndrome. A further aim was to assess whether the microRNA expression profiles in erythrodermic mycosis fungoides skin was more comparable to microRNA expression profiles of Sézary syndrome or early-stage mycosis fungoides. RNA was extracted from diagnostic skin biopsies, followed by quantitative reverse transcription polymerase chain reaction analysis of 383 microRNAs. Twenty-seven microRNAs were significantly differentially expressed between erythrodermic mycosis fungoides and Sézary syndrome. Moreover, erythrodermic mycosis fungoides showed microRNA features overlapping with Sézary syndrome and early-stage mycosis fungoides, although hierarchical cluster analysis co-clustered erythrodermic mycosis fungoides with early-stage mycosis fungoides rather than with Sézary syndrome. These findings underscore that erythrodermic mycosis fungoides and Sézary syndrome are different diseases. |
topic |
mycosis fungoides, sézary syndrome, cutaneous t cell lymphoma, microrna |
url |
https://www.medicaljournals.se/acta/content/html/10.2340/00015555-3306
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work_keys_str_mv |
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