ICP6 Prevents RIP1 Activation to Hinder Necroptosis Signaling

Necroptosis is a type of programmed necrosis which depends on the activation of receptor-interacting protein kinase 3 (RIP3). Herpes simplex virus type 1 (HSV-1) is known to block necroptosis by the viral protein ICP6 in human cells, but its specific inhibitory mechanism is not fully understood. Her...

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Main Authors:	Hong Hu, Guoxiang Wu, Zhaoqian Shu, Dandan Yu, Ning Nan, Feiyang Yuan, Xiaoyan Liu, Huayi Wang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2020-10-01
Series:	Frontiers in Cell and Developmental Biology
Subjects:	necrosome RIP3 necroptosis RIP1 ICP6
Online Access:	https://www.frontiersin.org/articles/10.3389/fcell.2020.595253/full

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spelling	doaj-8cf72672b2fd4010948fef15bc9b77152020-11-25T01:40:42ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2020-10-01810.3389/fcell.2020.595253595253ICP6 Prevents RIP1 Activation to Hinder Necroptosis SignalingHong Hu0Hong Hu1Hong Hu2Guoxiang Wu3Guoxiang Wu4Zhaoqian Shu5Zhaoqian Shu6Dandan Yu7Dandan Yu8Ning Nan9Ning Nan10Feiyang Yuan11Feiyang Yuan12Xiaoyan Liu13Huayi Wang14School of Life Science and Technology, ShanghaiTech University, Shanghai, ChinaCAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, ChinaUniversity of Chinese Academy of Sciences, Beijing, ChinaSchool of Life Science and Technology, ShanghaiTech University, Shanghai, ChinaUniversity of Chinese Academy of Sciences, Beijing, ChinaSchool of Life Science and Technology, ShanghaiTech University, Shanghai, ChinaUniversity of Chinese Academy of Sciences, Beijing, ChinaSchool of Life Science and Technology, ShanghaiTech University, Shanghai, ChinaUniversity of Chinese Academy of Sciences, Beijing, ChinaSchool of Life Science and Technology, ShanghaiTech University, Shanghai, ChinaUniversity of Chinese Academy of Sciences, Beijing, ChinaSchool of Life Science and Technology, ShanghaiTech University, Shanghai, ChinaUniversity of Chinese Academy of Sciences, Beijing, ChinaSchool of Life Science and Technology, ShanghaiTech University, Shanghai, ChinaSchool of Life Science and Technology, ShanghaiTech University, Shanghai, ChinaNecroptosis is a type of programmed necrosis which depends on the activation of receptor-interacting protein kinase 3 (RIP3). Herpes simplex virus type 1 (HSV-1) is known to block necroptosis by the viral protein ICP6 in human cells, but its specific inhibitory mechanism is not fully understood. Here we reported that ICP6 could promote rather than suppress the formation of necrosome, the necroptosis signaling complex containing RIP3 and upstream regulator receptor-interacting protein kinase 1 (RIP1), but blocked RIP3 activation. Moreover, ICP6 could reduce the necroptosis-specific auto-phosphorylation of RIP1 regardless of the presence of RIP3. These results indicate that ICP6 block necroptosis through preventing RIP1 activation dependent signal transduction in necrosome.https://www.frontiersin.org/articles/10.3389/fcell.2020.595253/fullnecrosomeRIP3necroptosisRIP1ICP6
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Hong Hu Hong Hu Hong Hu Guoxiang Wu Guoxiang Wu Zhaoqian Shu Zhaoqian Shu Dandan Yu Dandan Yu Ning Nan Ning Nan Feiyang Yuan Feiyang Yuan Xiaoyan Liu Huayi Wang
spellingShingle	Hong Hu Hong Hu Hong Hu Guoxiang Wu Guoxiang Wu Zhaoqian Shu Zhaoqian Shu Dandan Yu Dandan Yu Ning Nan Ning Nan Feiyang Yuan Feiyang Yuan Xiaoyan Liu Huayi Wang ICP6 Prevents RIP1 Activation to Hinder Necroptosis Signaling Frontiers in Cell and Developmental Biology necrosome RIP3 necroptosis RIP1 ICP6
author_facet	Hong Hu Hong Hu Hong Hu Guoxiang Wu Guoxiang Wu Zhaoqian Shu Zhaoqian Shu Dandan Yu Dandan Yu Ning Nan Ning Nan Feiyang Yuan Feiyang Yuan Xiaoyan Liu Huayi Wang
author_sort	Hong Hu
title	ICP6 Prevents RIP1 Activation to Hinder Necroptosis Signaling
title_short	ICP6 Prevents RIP1 Activation to Hinder Necroptosis Signaling
title_full	ICP6 Prevents RIP1 Activation to Hinder Necroptosis Signaling
title_fullStr	ICP6 Prevents RIP1 Activation to Hinder Necroptosis Signaling
title_full_unstemmed	ICP6 Prevents RIP1 Activation to Hinder Necroptosis Signaling
title_sort	icp6 prevents rip1 activation to hinder necroptosis signaling
publisher	Frontiers Media S.A.
series	Frontiers in Cell and Developmental Biology
issn	2296-634X
publishDate	2020-10-01
description	Necroptosis is a type of programmed necrosis which depends on the activation of receptor-interacting protein kinase 3 (RIP3). Herpes simplex virus type 1 (HSV-1) is known to block necroptosis by the viral protein ICP6 in human cells, but its specific inhibitory mechanism is not fully understood. Here we reported that ICP6 could promote rather than suppress the formation of necrosome, the necroptosis signaling complex containing RIP3 and upstream regulator receptor-interacting protein kinase 1 (RIP1), but blocked RIP3 activation. Moreover, ICP6 could reduce the necroptosis-specific auto-phosphorylation of RIP1 regardless of the presence of RIP3. These results indicate that ICP6 block necroptosis through preventing RIP1 activation dependent signal transduction in necrosome.
topic	necrosome RIP3 necroptosis RIP1 ICP6
url	https://www.frontiersin.org/articles/10.3389/fcell.2020.595253/full
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ICP6 Prevents RIP1 Activation to Hinder Necroptosis Signaling

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