Modafinil-induced Fixed Drug Eruption

• Main Authors: Girish Vasant Gaikwad, Chetali Vijay Dhuri
• Format: Article
• Language: English
• Published: SAGE Publishing 2012-01-01
• Series: Indian Journal of Psychological Medicine
• Subjects: Adverse drug reaction; fixed drug eruption; modafinil
• Online Access: http://www.ijpm.info/article.asp?issn=0253-7176;year=2012;volume=34;issue=4;spage=383;epage=384;aulast=Gaikwad

Modafinil is a stimulant drug widely used to promote wakefulness in a variety of psychiatric and neurological conditions. Modafinil-induced severe dermatologic reactions are uncommon but serious side effects. We report a patient who developed fixed drug eruption after exposure to a single dose of tablet modafinil. On assessment using the Naranjo scale, the score was five, which made us conclude that modafinil was the "probable" cause of the patient′s adverse drug event. This case report highlights the need to be alert toward the emergence of dermatologic side effects among patients taking modafinil.