Number of leprosy reactions during treatment: clinical correlations and laboratory diagnosis
Abstract INTRODUCTION: The occurrence of leprosy reactions, a common event during treatment, may be mostly related to the action of multidrug therapy on Mycobacterium leprae. The clinical and laboratory monitoring of patients with reactions is important, since collecting data that assists in predic...
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doaj-8d0792a98f114e9e972b87951ae5deda2020-11-24T23:28:58ZengSociedade Brasileira de Medicina Tropical (SBMT)Revista da Sociedade Brasileira de Medicina Tropical1678-984949674174510.1590/0037-8682-0440-2015S0037-86822016000600741Number of leprosy reactions during treatment: clinical correlations and laboratory diagnosisDouglas Eulálio AntunesGabriela Porto FerreiraMariana Vitorino Candeiro NicchioSergio AraujoAna Carolina Rodrigues da CunhaRafaela Resende GomesAdeilson Viera da CostaIsabela Maria Bernardes GoulartAbstract INTRODUCTION: The occurrence of leprosy reactions, a common event during treatment, may be mostly related to the action of multidrug therapy on Mycobacterium leprae. The clinical and laboratory monitoring of patients with reactions is important, since collecting data that assists in predicting the risk of reactions may help to prevent disability. METHODS: This was a sectional study, in order to correlate clinical and laboratory diagnosis with the number of reactions during treatment. Spearman's correlation was used to verify the degree of association between the assessed variables. RESULTS: This study was conducted with 211 patients with leprosy reactions during treatment of M. leprae. The borderline tuberculoid group was the most prevalent clinical form (74/211; 35.1%) and the type one reaction showed the highest frequency (136/211; 64.5%). It was observed that 73.5% (155/211) of reactions occurred within 3 months of the initiation of multidrug therapy. The diagnostic values, including the bacterial indices (BIs) of dermal smears (r = 0.21, p < 0.05) and skin biopsies (r = 0.20; p < 0.05), showed a positive correlation with the number of reactions during treatment. CONCLUSIONS: This research showed a positive correlation between bacillary load markers and the number of leprosy reactions. This study provided scientific support to future research aiming to elucidate the influence of antigenic load on the number of leprosy reactions during treatment.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822016000600741&lng=en&tlng=enLeprosyLeprosy reactionsClinical correlationLaboratory diagnosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Douglas Eulálio Antunes Gabriela Porto Ferreira Mariana Vitorino Candeiro Nicchio Sergio Araujo Ana Carolina Rodrigues da Cunha Rafaela Resende Gomes Adeilson Viera da Costa Isabela Maria Bernardes Goulart |
spellingShingle |
Douglas Eulálio Antunes Gabriela Porto Ferreira Mariana Vitorino Candeiro Nicchio Sergio Araujo Ana Carolina Rodrigues da Cunha Rafaela Resende Gomes Adeilson Viera da Costa Isabela Maria Bernardes Goulart Number of leprosy reactions during treatment: clinical correlations and laboratory diagnosis Revista da Sociedade Brasileira de Medicina Tropical Leprosy Leprosy reactions Clinical correlation Laboratory diagnosis |
author_facet |
Douglas Eulálio Antunes Gabriela Porto Ferreira Mariana Vitorino Candeiro Nicchio Sergio Araujo Ana Carolina Rodrigues da Cunha Rafaela Resende Gomes Adeilson Viera da Costa Isabela Maria Bernardes Goulart |
author_sort |
Douglas Eulálio Antunes |
title |
Number of leprosy reactions during treatment: clinical correlations and laboratory diagnosis |
title_short |
Number of leprosy reactions during treatment: clinical correlations and laboratory diagnosis |
title_full |
Number of leprosy reactions during treatment: clinical correlations and laboratory diagnosis |
title_fullStr |
Number of leprosy reactions during treatment: clinical correlations and laboratory diagnosis |
title_full_unstemmed |
Number of leprosy reactions during treatment: clinical correlations and laboratory diagnosis |
title_sort |
number of leprosy reactions during treatment: clinical correlations and laboratory diagnosis |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
series |
Revista da Sociedade Brasileira de Medicina Tropical |
issn |
1678-9849 |
description |
Abstract INTRODUCTION: The occurrence of leprosy reactions, a common event during treatment, may be mostly related to the action of multidrug therapy on Mycobacterium leprae. The clinical and laboratory monitoring of patients with reactions is important, since collecting data that assists in predicting the risk of reactions may help to prevent disability. METHODS: This was a sectional study, in order to correlate clinical and laboratory diagnosis with the number of reactions during treatment. Spearman's correlation was used to verify the degree of association between the assessed variables. RESULTS: This study was conducted with 211 patients with leprosy reactions during treatment of M. leprae. The borderline tuberculoid group was the most prevalent clinical form (74/211; 35.1%) and the type one reaction showed the highest frequency (136/211; 64.5%). It was observed that 73.5% (155/211) of reactions occurred within 3 months of the initiation of multidrug therapy. The diagnostic values, including the bacterial indices (BIs) of dermal smears (r = 0.21, p < 0.05) and skin biopsies (r = 0.20; p < 0.05), showed a positive correlation with the number of reactions during treatment. CONCLUSIONS: This research showed a positive correlation between bacillary load markers and the number of leprosy reactions. This study provided scientific support to future research aiming to elucidate the influence of antigenic load on the number of leprosy reactions during treatment. |
topic |
Leprosy Leprosy reactions Clinical correlation Laboratory diagnosis |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822016000600741&lng=en&tlng=en |
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