Infantile Pyknocytosis: End-Tidal CO, %Micro-R Measurements, Next-Generation Sequencing, and Transfusion Avoidance with Darbepoetin

Infantile Pyknocytosis: End-Tidal CO, %Micro-R Measurements, Next-Generation Sequencing, and Transfusion Avoidance with Darbepoetin

Infantile pyknocytosis is a rare, self-limited, hemolytic condition of unknown pathogenesis. It is diagnosed when a neonate with Coombs-negative hemolytic anemia has abundant pyknocytes and a characteristic clinical course after other hemolytic disorders has been excluded. Previous reports suggest t...

Full description

Bibliographic Details
Main Authors: Timothy M. Bahr, Mari C. Knudsen, Michell Lozano-Chinga, Archana M. Agarwal, Jessica A. Meznarich, Robin K. Ohls, Robert D. Christensen
Format: Article
Language:English
Published: Karger Publishers 2020-12-01
Series:Biomedicine Hub
Subjects:
hemolysis
hyperbilirubinemia
darbepoetin
next-generation sequencing
Online Access:https://www.karger.com/Article/FullText/511388
id doaj-8d08eb46e1f04099bb5136e48351a4f7
record_format Article
spelling doaj-8d08eb46e1f04099bb5136e48351a4f72021-01-07T15:05:23ZengKarger PublishersBiomedicine Hub2296-68702020-12-01531810.1159/000511388511388Infantile Pyknocytosis: End-Tidal CO, %Micro-R Measurements, Next-Generation Sequencing, and Transfusion Avoidance with DarbepoetinTimothy M. BahrMari C. KnudsenMichell Lozano-ChingaArchana M. AgarwalJessica A. MeznarichRobin K. OhlsRobert D. ChristensenInfantile pyknocytosis is a rare, self-limited, hemolytic condition of unknown pathogenesis. It is diagnosed when a neonate with Coombs-negative hemolytic anemia has abundant pyknocytes and a characteristic clinical course after other hemolytic disorders has been excluded. Previous reports suggest that transfusions might be avoidable in this condition by administering recombinant erythropoietin. We cared for a patient with this disorder where we employed novel diagnostics and therapeutics. Despite these, and a good outcome free of transfusions, we continue to consider the condition to be idiopathic.https://www.karger.com/Article/FullText/511388hemolysishyperbilirubinemiadarbepoetinnext-generation sequencing
collection DOAJ
language English
format Article
sources DOAJ
author Timothy M. Bahr
Mari C. Knudsen
Michell Lozano-Chinga
Archana M. Agarwal
Jessica A. Meznarich
Robin K. Ohls
Robert D. Christensen
spellingShingle Timothy M. Bahr
Mari C. Knudsen
Michell Lozano-Chinga
Archana M. Agarwal
Jessica A. Meznarich
Robin K. Ohls
Robert D. Christensen
Infantile Pyknocytosis: End-Tidal CO, %Micro-R Measurements, Next-Generation Sequencing, and Transfusion Avoidance with Darbepoetin
Biomedicine Hub
hemolysis
hyperbilirubinemia
darbepoetin
next-generation sequencing
author_facet Timothy M. Bahr
Mari C. Knudsen
Michell Lozano-Chinga
Archana M. Agarwal
Jessica A. Meznarich
Robin K. Ohls
Robert D. Christensen
author_sort Timothy M. Bahr
title Infantile Pyknocytosis: End-Tidal CO, %Micro-R Measurements, Next-Generation Sequencing, and Transfusion Avoidance with Darbepoetin
title_short Infantile Pyknocytosis: End-Tidal CO, %Micro-R Measurements, Next-Generation Sequencing, and Transfusion Avoidance with Darbepoetin
title_full Infantile Pyknocytosis: End-Tidal CO, %Micro-R Measurements, Next-Generation Sequencing, and Transfusion Avoidance with Darbepoetin
title_fullStr Infantile Pyknocytosis: End-Tidal CO, %Micro-R Measurements, Next-Generation Sequencing, and Transfusion Avoidance with Darbepoetin
title_full_unstemmed Infantile Pyknocytosis: End-Tidal CO, %Micro-R Measurements, Next-Generation Sequencing, and Transfusion Avoidance with Darbepoetin
title_sort infantile pyknocytosis: end-tidal co, %micro-r measurements, next-generation sequencing, and transfusion avoidance with darbepoetin
publisher Karger Publishers
series Biomedicine Hub
issn 2296-6870
publishDate 2020-12-01
description Infantile pyknocytosis is a rare, self-limited, hemolytic condition of unknown pathogenesis. It is diagnosed when a neonate with Coombs-negative hemolytic anemia has abundant pyknocytes and a characteristic clinical course after other hemolytic disorders has been excluded. Previous reports suggest that transfusions might be avoidable in this condition by administering recombinant erythropoietin. We cared for a patient with this disorder where we employed novel diagnostics and therapeutics. Despite these, and a good outcome free of transfusions, we continue to consider the condition to be idiopathic.
topic hemolysis
hyperbilirubinemia
darbepoetin
next-generation sequencing
url https://www.karger.com/Article/FullText/511388
work_keys_str_mv AT timothymbahr infantilepyknocytosisendtidalcomicrormeasurementsnextgenerationsequencingandtransfusionavoidancewithdarbepoetin
AT maricknudsen infantilepyknocytosisendtidalcomicrormeasurementsnextgenerationsequencingandtransfusionavoidancewithdarbepoetin
AT michelllozanochinga infantilepyknocytosisendtidalcomicrormeasurementsnextgenerationsequencingandtransfusionavoidancewithdarbepoetin
AT archanamagarwal infantilepyknocytosisendtidalcomicrormeasurementsnextgenerationsequencingandtransfusionavoidancewithdarbepoetin
AT jessicaameznarich infantilepyknocytosisendtidalcomicrormeasurementsnextgenerationsequencingandtransfusionavoidancewithdarbepoetin
AT robinkohls infantilepyknocytosisendtidalcomicrormeasurementsnextgenerationsequencingandtransfusionavoidancewithdarbepoetin
AT robertdchristensen infantilepyknocytosisendtidalcomicrormeasurementsnextgenerationsequencingandtransfusionavoidancewithdarbepoetin
_version_ 1724346519904059392

Similar Items