A case of beta-thalassaemia major resistant to standard treatment

A case of beta-thalassaemia major resistant to standard treatment

We report the case of a 22-year-old woman from Albania, with thalassaemia major, in severe clinical condition who could no longer be transfused due to the occurrence of severe, acute, post-transfusional reactions. After 10 years of treatment, she failed to respond to hydroxyurea. When she received t...

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Main Authors: Nicoletta Masera, Valentina Decimi, Luisa Tavecchia, Marietta Capra, Giovanni Cazzaniga, Andrea Biondi, Giuseppe Masera
Format: Article
Language:English
Published: SEEd 2010-06-01
Series:Clinical Management Issues
Subjects:
Thalassaemia
Thalidomide
Foetal haemoglobin
Online Access:https://journals.seedmedicalpublishers.com/index.php/cmi/article/view/531
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spelling doaj-8d0c8b288e7149ed92b69b86fd13bc512020-11-25T00:57:32ZengSEEdClinical Management Issues1973-48322283-31372010-06-0142657010.7175/cmi.v4i2.531498A case of beta-thalassaemia major resistant to standard treatmentNicoletta Masera0Valentina Decimi1Luisa Tavecchia2Marietta Capra3Giovanni Cazzaniga4Andrea Biondi5Giuseppe Masera6Clinica pediatrica, Università di Milano-Bicocca, Ospedale San Gerardo, MonzaClinica pediatrica, Università di Milano-Bicocca, Ospedale San Gerardo, MonzaCentro Immunotrasfusionale, Ospedale San Gerardo, MonzaCentro Immunotrasfusionale, Ospedale San Gerardo, MonzaCentro Immunotrasfusionale, Ospedale San Gerardo, MonzaClinica pediatrica, Università di Milano-Bicocca, Ospedale San Gerardo, MonzaClinica pediatrica, Università di Milano-Bicocca, Ospedale San Gerardo, MonzaWe report the case of a 22-year-old woman from Albania, with thalassaemia major, in severe clinical condition who could no longer be transfused due to the occurrence of severe, acute, post-transfusional reactions. After 10 years of treatment, she failed to respond to hydroxyurea. When she received thalidomide, haemoglobin levels increased from 3.7 g/dl to 9 g/dl. Since then, at 22 months of follow-up, the therapy is still effective and well tolerated. The case gives the opportunity to describe the clinical use of thalidomide, and its potential in the management of beta-thalassaemia.https://journals.seedmedicalpublishers.com/index.php/cmi/article/view/531ThalassaemiaThalidomideFoetal haemoglobin
collection DOAJ
language English
format Article
sources DOAJ
author Nicoletta Masera
Valentina Decimi
Luisa Tavecchia
Marietta Capra
Giovanni Cazzaniga
Andrea Biondi
Giuseppe Masera
spellingShingle Nicoletta Masera
Valentina Decimi
Luisa Tavecchia
Marietta Capra
Giovanni Cazzaniga
Andrea Biondi
Giuseppe Masera
A case of beta-thalassaemia major resistant to standard treatment
Clinical Management Issues
Thalassaemia
Thalidomide
Foetal haemoglobin
author_facet Nicoletta Masera
Valentina Decimi
Luisa Tavecchia
Marietta Capra
Giovanni Cazzaniga
Andrea Biondi
Giuseppe Masera
author_sort Nicoletta Masera
title A case of beta-thalassaemia major resistant to standard treatment
title_short A case of beta-thalassaemia major resistant to standard treatment
title_full A case of beta-thalassaemia major resistant to standard treatment
title_fullStr A case of beta-thalassaemia major resistant to standard treatment
title_full_unstemmed A case of beta-thalassaemia major resistant to standard treatment
title_sort case of beta-thalassaemia major resistant to standard treatment
publisher SEEd
series Clinical Management Issues
issn 1973-4832
2283-3137
publishDate 2010-06-01
description We report the case of a 22-year-old woman from Albania, with thalassaemia major, in severe clinical condition who could no longer be transfused due to the occurrence of severe, acute, post-transfusional reactions. After 10 years of treatment, she failed to respond to hydroxyurea. When she received thalidomide, haemoglobin levels increased from 3.7 g/dl to 9 g/dl. Since then, at 22 months of follow-up, the therapy is still effective and well tolerated. The case gives the opportunity to describe the clinical use of thalidomide, and its potential in the management of beta-thalassaemia.
topic Thalassaemia
Thalidomide
Foetal haemoglobin
url https://journals.seedmedicalpublishers.com/index.php/cmi/article/view/531
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