Bmi-1 Regulates Snail Expression and Promotes Metastasis Ability in Head and Neck Squamous Cancer-Derived ALDH1 Positive Cells

Recent studies suggest that ALDH1 is a putative marker for HNSCC-derived cancer stem cells. However, the regulation mechanisms that maintain the stemness and metastatic capability of HNSCC-ALDH1+ cells remain unclear. Initially, HNSCC-ALDH1+ cells from HNSCC patient showed cancer stemness properties...

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Main Authors: Cheng-Chia Yu, Wen-Liang Lo, Yi-Wei Chen, Pin-I Huang, Han-Shui Hsu, Ling-Ming Tseng, Shih-Chieh Hung, Shou-Yen Kao, Charn-Jung Chang, Shih Hwa Chiou
Format: Article
Language:English
Published: Hindawi Limited 2011-01-01
Series:Journal of Oncology
Online Access:http://dx.doi.org/10.1155/2011/609259